A Personalized Fractional Produce Maker For Superfluous Double Multipliers

In this RBMPPG (modified component product) generator is recommended; it removes the additional ECW and thus provides a single step for RBPP collection. Due to this high portability and no additional load, redundant binary (RB) can be used to create high performance servo. The traditional RB extension requires one line extension to the selected RB product (RBPP), because the error correction voice (ECW) is made up of both Radiated Radix-4 root recording (MBE) and RB code. This occurs during one additional RBPP component of the MBE expansion component.  Therefore, the planned RBMPPG produces fewer production products compared to the standard RB MBE multiplier. The results show that the proposed RBMPPG-based design significantly improves the space and power consumption or voice length of each parliamentary in this extension is approximately thirty-three; this reduction over previous NB servo leads to a slight increase in delay (approximately 6%). The power of the product delay can be reduced to ninety-five percent using the selected Serb rib compared to the existing RB servo

High-Yielding Multicut Coriander Variety, Arka Isha

Coriander (Coriandrum sativum L.) is one of the important leafy vegetables having a pleasant aroma. Very little research work has been done on improvement of leafy coriander and only a few local varieties, low-yielding and with low aroma, are available in the market. Research work at Indian Institute of Horticultural Research has resulted in development of a leafy coriander variety, Arka Isha, with a high yield potential and good aroma. It is a multicut variety where the plants are bushy, leaves are broad and leaf lobes are short, and the variety is late flowering. Yield is 3.74t ha-1 by pulling at 40 days after sowing, and 11.98t ha-1 by cutting. Leaves have 167.05mg 100g-1 of Vitamin C, with good aroma and keeping-quality

SYNTHESIS, IN SILICO STUDIES AND EVALUATION OF ANTIBACTERIAL ACTIVITY OF 4-SUBSTITUTED BENZYLIDENE-2-(PHENOXYMETHYL) OXAZOL-5(4H)-ONES

Objective: Arylidene-1, 3-oxazol-5-ones represent potential antibacterial agents. In the present work, a series of 4-substituted benzylidene-2- (phenoxymethyl) oxazol-5(4H)-ones were synthesized and screened for antibacterial activity against Gram-negative bacteria Escherichia coli. To explore plausible mechanisms, synthesized compounds were docked with DNA-Gyrase enzyme. Methods: All the reactants, phenoxy acetyl chloride, acetic anhydride, sodium acetate, substituted aromatic aldehydes, and glycine were triturated in a mortar by mechanical stirring. The antibacterial potentiality of the compounds was screened against E. coli using the disk diffusion method and the activity was recorded as a zone of inhibition. Results: Compound 2d, possessing 3, 4, 5-trimethoxy functionality on benzylidene ring exhibited the highest activity with 19 mm of the zone of inhibition which might be due to its higher interactions with DNA-Gyrase enzyme (ΔG-8.41 kcal/mol). Compounds 2a, 2b, and 2c exhibited moderate activity in the antimicrobial assay as well as in docking study indicating the positive contribution of substitution on benzylidene ring. Conclusion: A series of 4-substituted benzylidene-2-(phenoxymethyl) oxazol-5(4H)-ones were synthesized and evaluated for antibacterial activity. Compounds 2a, 2b, and 2c displayed moderate activity whereas 2d showed maximum zone of inhibition (19 mm). The good activity of these derivatives presumed to be due to the conformational flexibility of phenoxy methylene moiety which can be well accommodated in the target binding site

Microfluidic-assisted synthesis of metal—organic framework —alginate micro-particles for sustained drug delivery

Drug delivery systems (DDS) are continuously being explored since humans are facing more numerous complicated diseases than ever before. These systems can preserve the drug’s functionality and improve its efficacy until the drug is delivered to a specific site within the body. One of the least used materials for this purpose are metal—organic frameworks (MOFs). MOFs possess many properties, including their high surface area and the possibility for the addition of functional surface moieties, that make them ideal drug delivery vehicles. Such properties can be further improved by combining different materials (such as metals or ligands) and utilizing various synthesis techniques. In this work, the microfluidic technique is used to synthesize Zeolitic Imidazole Framework-67 (ZIF-67) containing cobalt ions as well as its bimetallic variant with cobalt and zinc as ZnZIF-67 to be subsequently loaded with diclofenac sodium and incorporated into sodium alginate beads for sustained drug delivery. This study shows the utilization of a microfluidic approach to synthesize MOF variants. Furthermore, these MOFs were incorporated into a biopolymer (sodium alginate) to produce a reliable DDS which can perform sustained drug releases for up to 6 days (for 90% of the full amount released), whereas MOFs without the biopolymer showed sudden release within the first day.Department of Science and Technology (DST), India | Ref. DST/BDTD/EAG/2019Department of Science and Technology (DST), India | Ref. DST/TDT/DDP-31/2021Vision Group for Science and Technology (VGST), India | Ref. VGST/K-FISTL1/GRD No. 1053/2021-22Jain University, Minor Project | Ref. JU/MRP/Uni/3/202

Process Documentation Research and Impact of Community-Driven Development Grants Research in Rural India, Socioeconomics Discussion Paper Series 34

In 2011 ICRISAT gave experimental grants to six dryland villages targeted by the “Village Dynamics Studies in South Asia” (VDSA) project. Two villages were located in Telangana state (undivided Andhra Pradesh) and four in Maharashtra state. A grant of USD 7,000 (Rs. 315,000) was given to each villages to assess the role of local governance and institutions on agricultural performance, and to evaluate development pathways. The community was free to decide where and how to use the grant. Using the Process Documentation Research (PDR) framework, this report documents the activities of the ICRISAT-VDSA project team and the community implementation committee in using the grant, and lessons learned in the process. We also estimated the number of beneficiaries and the economic benefits from the grant. In two villages, the annual economic benefits from the grant were almost equal to the total grant expenditure. In five villages, the cumulative benefits over the last four years exceeded the total value of the grant. Unlike other publically-funded projects, large numbers of households from minority and socially weaker sections also benefited. The results suggest that, given the opportunity, local communities can effectively execute local infrastructure development projects through need-based collective action, while lowering the transaction costs of community action. By involving local community members in planning and implementing projects, the village grant provided benefits to a large number of households and generated substantial economic benefits. The experiment provides useful lessons for scaling-out village grants to other project villages, and for rural development agencies in India and elsewhere

Genetic Aspects of Implantation Failure

Implantation failure refers to the inability of a fertilized egg, or embryo, to successfully implant itself in the endometrial lining of the uterus, leading to pregnancy loss. The repeated failure of good quality embryo implantation is referred to as recurrent implantation failure (RIF). This can occur for a variety of reasons, including chromosomal abnormalities in the embryo, problems with the endometrium, or issues with the immune system. Factors such as advanced maternal age, obesity, smoking, and certain medical conditions can also increase the risk of implantation failure. While treatment such as in vitro fertilization (IVF) can help to improve the chances of successful implantation, there is currently no definite way to prevent or treat implantation failure.  Patients and healthcare professionals have substantial diagnostic and treatment hurdles as a result of many etiological factors and lack of knowledge about RIF. A number of studies have indicated a correlation between irregular hormone levels, disruptions in angiogenic and immunomodulatory factors, specific genetic polymorphisms, and the prevalence of RIF. Nonetheless, the precise and intricate underlying pathophysiology of RIF remains elusive.  However, many studies are ongoing in this field to understand the underlying causes and to find new ways to help couples achieve pregnancy. This review article extensively explores diverse molecular and genetic facets aimed at enhancing the diagnosis and management of implantation failure

Serum Metabolomics Reveals Higher Levels of Polyunsaturated Fatty Acids in Lepromatous Leprosy: Potential Markers for Susceptibility and Pathogenesis

Leprosy is an infectious disease caused by the obligate intracellular bacterium Mycobacterium leprae. M. leprae infects the skin and nerves, leading to disfigurement and nerve damage, with the severity of the disease varying widely. We believe there are multiple factors (genetic, bacterial, nutritional and environmental), which may explain the differences in clinical manifestations of the disease. We studied the metabolites in the serum of infected patients to search for specific molecules that may contribute to variations in the severity of disease seen in leprosy. We found that there were variations in levels of certain lipids in the patients with different bacterial loads. In particular, we found that three polyunsaturated fatty acids (PUFAs) involved in the inhibition of inflammation were more abundant in the serum of patients with higher bacterial loads. However, we do not know whether these PUFAs originated from the host or the bacteria. The variations in the metabolite profile that we observed provide a foundation for future research into the explanations of how leprosy causes disease

Are textbook lungs really normal? A cadaveric study on the anatomical and clinical importance of variations in the major lung fissures, and the incomplete right horizontal fissure.

INTRODUCTION: The lungs have three main fissures: the right oblique fissure (ROF), right horizontal fissure (RHF), and left oblique fissure (LOF). These can be complete, incomplete or absent; quantifying the degree of completeness of these fissures is novel. Standard textbooks often refer to the fissures as complete, but awareness of variation is essential in thoracic surgery. MATERIALS AND METHODS: Fissures in 81 pairs of cadaveric lungs were classified. Oblique fissures were measured from lung hila posteriorly to the lung hila anteriorly; and the RHF measured from the ROF to the anteromedial lung edge. The degree of completeness of fissures was expressed as a percentage of the total projected length were they to be complete. The frequency and location of accessory fissures was noted. RESULTS: LOF were complete in 66/81 (81.5%), incomplete in 13/81 (16.0%) and absent in 2/81 (2.47%); ROF were complete in 52/81 (64.2%), incomplete in 29/81 (35.8%) and never absent; RHF were more variable, complete in 18/81 (22.2%), incomplete in 54/81 (66.7%) and absent in 9/81 (11.1%). LOF and ROF were on average 97.1% and 91.6% complete, respectively, being deficient posteriorly at the lung hila. The RHF on average 69.4% complete, being deficient anteromedially. There were accessory fissures in 10 left and 19 right lungs. CONCLUSIONS: This study provides a projection of the anatomy thoracic surgeons may encounter at operation, in particular the variable RHF. This knowledge is essential for optimal outcomes in both benign and oncological procedures influenced by the fissures

High ALDH Activity Identifies Chemotherapy-Resistant Ewing's Sarcoma Stem Cells That Retain Sensitivity to EWS-FLI1 Inhibition

Cancer stem cells are a chemotherapy-resistant population capable of self-renewal and of regenerating the bulk tumor, thereby causing relapse and patient death. Ewing's sarcoma, the second most common form of bone tumor in adolescents and young adults, follows a clinical pattern consistent with the Cancer Stem Cell model - remission is easily achieved, even for patients with metastatic disease, but relapse remains frequent and is usually fatal.We have isolated a subpopulation of Ewing's sarcoma cells, from both human cell lines and human xenografts grown in immune deficient mice, which express high aldehyde dehydrogenase (ALDH(high)) activity and are enriched for clonogenicity, sphere-formation, and tumor initiation. The ALDH(high) cells are resistant to chemotherapy in vitro, but this can be overcome by the ATP binding cassette transport protein inhibitor, verapamil. Importantly, these cells are not resistant to YK-4-279, a small molecule inhibitor of EWS-FLI1 that is selectively toxic to Ewing's sarcoma cells both in vitro and in vivo.Ewing's sarcoma contains an ALDH(high) stem-like population of chemotherapy-resistant cells that retain sensitivity to EWS-FLI1 inhibition. Inhibiting the EWS-FLI1 oncoprotein may prove to be an effective means of improving patient outcomes by targeting Ewing's sarcoma stem cells that survive standard chemotherapy