92 research outputs found
Epidemiologija and etiologija ploÄastog karcinoma glave i vrata
Introduction: It was expected at least in Western countries that incidence of head and neck cancers (HNSCC) should become lower due to the propaganda against smoking. However, the expected decrease in HNSCC was not achieved in many countries. Tobacco and alcohol consumption are known as a major risk factors for development of HNSCC. It is well known that 15-20% of HNSCC are linked to HPV infection, however, some authors reported coexistence with other viruses as well. In the Eastern countries paan (betel nut), ghutka, that have been also linked to the development HNSCC. However, lately HNSCC have been linked to the low vegetable and fruit intake, vitamin defi ciencies, coinfection with other viruses, certain genetic syndromes and occupational exposure. Therefore, the aim of this study is to review recent literature regarding epidemiology and other risk factors in the development of HNSCC.
Methods: Pubmed was searched in the past two years in order to fi nd out novelties regarding epidemiology and aetiology for HNSCC and 34 papers were included.
Results and Conclusion: The results of this review paper show that smoking is a major contributing factor especially with alcohol both being dosed and time dependent in the development of HNSCC. Unhealthy diet, decrease in vitamin intake especially folate, C and E vitamin and occupational exposure were seen in the diseased. In about one fourth of the patients infection with HPV has been noticed, and in some coinfection with other viruses such as Epstein Barr, cytomegalovirus
and HIV. Obviously genetic predisposition exists but also correlation with certain genetic syndromes such as Fanconiās anaemia and Bloom syndrome.Uvod: OÄekivalo se barem u Zapadnim zemljama kako Äe incidencija karcinoma glave i vrata biti manja uslijed propagande protiv puÅ”enja. Ipak, oÄekivano smanjenje u incidenciji karcinoma glave i vrata nije postignuto u mnogim zemljama. PuÅ”enje i konzumacija alkohola su glavni faktori rizika za nastanak karcinoma glave i vrata. Dobro je poznato da je 15-20% karcinoma glave i vrata povezao s HPV infekcijom, doduÅ”e, neki autori su izvijestili i o koegzistenciji s drugim virusima takoÄer. U istoÄnim zemljama paan (betel nut), ghutka su takoÄer povezani s nastankom carcinoma glave i vrata. Ipak,
nedavno je karcinom glave i vrata povezan s rijetkim unosom povrÄa i voÄa, defi citom vitamina, koinfekcijom s drugim virusima, odreÄenim genetskim sindromima i radnim okoliÅ”em. Stoga je cilj ovog istraživanja bio pregledati noviju literature s obzirom na epidemiologiju i druge riziÄne faktore u nastanku karcinoma glave i vrata.
Metode: Pubmed je pretražen u zadnje dvije godine kako bi se ustanovilo novosti vezane uz epidemiologiju i etiologiju karcinoma glave i vrata te su 34 rada ukljuÄena.
Rezultati i zakljuÄci: Rezultati ovog preglednog rada pokazuju kako je puÅ”enje najvažniji faktor koji doprinosi nastanku karcinoma glave i vrata uz konzumiranje alkohola, a Å”to ovisi o dozi i vremenu izloženosti. Nezdrava prehrana,smanjeni unos vitamina, posebice folata, C i E vitamina i radni okoliÅ” se ustanove u oboljelih. U oko Äetvrtine pacijenata je ustanovljena infekcija s HPV virusom, a u nekih i koinfekcija s drugim virusima poput Epstein Barrovog, citomegalovirusa
i HIV-a. OÄito genetska predispozicija postoji ali i korelacija sa odreÄenim genetskim sindromima poput Fankonijeve anemije
i Bloomovog sindroma
Orofacial Pain of Non-Odontogenic Cause-Retrospective Study on 100 Patients Referred to the Primary Dental Health Care
Dijagnoza orofacijalne boli je esencijalna i Äesto nedovoljno cijenjena sastavnica stomatoloÅ”ke prakse. Svrha ovoga retrospektivnog ispitivanja bila je ustanoviti uzroke, navesti dijagnostiÄke postupke i kliniÄke manifestacije neodontogene orofacijalne boli u 100 pacijenata koji su upuÄeni u primarnu stomatoloÅ”ku zaÅ”titu. U naÅ”ih bolesnika bol se je najÄeÅ”Äe javljala u maksili, zatim mandibuli, uhu i TMZ-u. Upala je kod veÄine bila prateÄi simptom. Karakter boli opisan je kao duboka, jednostrana, tupa, izdrživa i pulsirajuÄa bol. 44 pacijenta su navela stres i podjedanko su rasporeÄeni po spolu. ProsjeÄno trajanje simptoma prije dolaska stomatologu bilo je 4,23 mjeseca. ProsjeÄno trajanje boli jednom kad bi poÄela bilo je 8 sati. NajÄeÅ”Äi uzroci neodontogene boli su bili maligni tumori usne Å”upljine, bolesti TMZ-a i trigeminalna neuralgija.The diagnosis of orofacial pain is an essential and frequently undervalued component of dental practice. The aim of this retrospective study was to report causes, diagnostic procedures applied and clinical manifestations of non-odontogenic orofacial pain in patients referred to primary dental care. In our patients, pain most frequently occurred in the maxilla, followed by the mandible, ear and temporomandibular joint (TMJ). Out of the accompanying symptoms, inflammation was reported in most of the patients. The character of the pain was described as deep, unilateral, dull, bearable, and pulsing. Forty-four patients reported stress with equal distribution according to the gender of patients. The average duration of pain before seeking the professional help of a dentist was 4.23 months. The average duration of pain once it had started was 8 hours. Most frequent causes of non-odontogenic pain in our patients were malignant tumors in the oral cavity, followed by TMJ disorders and trigeminal neuralgia
Epidemiologija and etiologija ploÄastog karcinoma glave i vrata
Introduction: It was expected at least in Western countries that incidence of head and neck cancers (HNSCC) should become lower due to the propaganda against smoking. However, the expected decrease in HNSCC was not achieved in many countries. Tobacco and alcohol consumption are known as a major risk factors for development of HNSCC. It is well known that 15-20% of HNSCC are linked to HPV infection, however, some authors reported coexistence with other viruses as well. In the Eastern countries paan (betel nut), ghutka, that have been also linked to the development HNSCC. However, lately HNSCC have been linked to the low vegetable and fruit intake, vitamin defi ciencies, coinfection with other viruses, certain genetic syndromes and occupational exposure. Therefore, the aim of this study is to review recent literature regarding epidemiology and other risk factors in the development of HNSCC.
Methods: Pubmed was searched in the past two years in order to fi nd out novelties regarding epidemiology and aetiology for HNSCC and 34 papers were included.
Results and Conclusion: The results of this review paper show that smoking is a major contributing factor especially with alcohol both being dosed and time dependent in the development of HNSCC. Unhealthy diet, decrease in vitamin intake especially folate, C and E vitamin and occupational exposure were seen in the diseased. In about one fourth of the patients infection with HPV has been noticed, and in some coinfection with other viruses such as Epstein Barr, cytomegalovirus
and HIV. Obviously genetic predisposition exists but also correlation with certain genetic syndromes such as Fanconiās anaemia and Bloom syndrome.Uvod: OÄekivalo se barem u Zapadnim zemljama kako Äe incidencija karcinoma glave i vrata biti manja uslijed propagande protiv puÅ”enja. Ipak, oÄekivano smanjenje u incidenciji karcinoma glave i vrata nije postignuto u mnogim zemljama. PuÅ”enje i konzumacija alkohola su glavni faktori rizika za nastanak karcinoma glave i vrata. Dobro je poznato da je 15-20% karcinoma glave i vrata povezao s HPV infekcijom, doduÅ”e, neki autori su izvijestili i o koegzistenciji s drugim virusima takoÄer. U istoÄnim zemljama paan (betel nut), ghutka su takoÄer povezani s nastankom carcinoma glave i vrata. Ipak,
nedavno je karcinom glave i vrata povezan s rijetkim unosom povrÄa i voÄa, defi citom vitamina, koinfekcijom s drugim virusima, odreÄenim genetskim sindromima i radnim okoliÅ”em. Stoga je cilj ovog istraživanja bio pregledati noviju literature s obzirom na epidemiologiju i druge riziÄne faktore u nastanku karcinoma glave i vrata.
Metode: Pubmed je pretražen u zadnje dvije godine kako bi se ustanovilo novosti vezane uz epidemiologiju i etiologiju karcinoma glave i vrata te su 34 rada ukljuÄena.
Rezultati i zakljuÄci: Rezultati ovog preglednog rada pokazuju kako je puÅ”enje najvažniji faktor koji doprinosi nastanku karcinoma glave i vrata uz konzumiranje alkohola, a Å”to ovisi o dozi i vremenu izloženosti. Nezdrava prehrana,smanjeni unos vitamina, posebice folata, C i E vitamina i radni okoliÅ” se ustanove u oboljelih. U oko Äetvrtine pacijenata je ustanovljena infekcija s HPV virusom, a u nekih i koinfekcija s drugim virusima poput Epstein Barrovog, citomegalovirusa
i HIV-a. OÄito genetska predispozicija postoji ali i korelacija sa odreÄenim genetskim sindromima poput Fankonijeve anemije
i Bloomovog sindroma
Stimulation of Saliva in Physiological Conditions by C-Vitamins and Chewing gum
U 20 žena i 20 muÅ”karaca, studenata 5. godine stomatologije, sa zdravim oralnim sluznicama i saniranim zubima, kvantificirana je nestimulirana i stimulirana slina. Prvim mjerenjem, koje je provedeno tako da su je izbacivali u epruvetu (0,1 skala) tijekom 5 minuta, odreÄena je nestimulirana slina. Sedam dana poslije mjerena je stimulirana slina poÅ”to su studenti pili vodenu otopinu askrobinske kiseline (lg na 1 del), te skupljali slinu u epruvetu tijekom 5 minuta. Mjerenjem nakon 14 dana dobivena je stimulirana slina poÅ”to su 1 minutu žvakali žvakaÄu gumu āOrbit ā, te izbacivali slinu u epruvetu tijekom 5 minuta. Svrha istraživanja bila je odrediti razlike u koliÄini nestimulirane i stimulirane sline, ovisnost sekrecije sline o vrsti stimulacije, razlike u koliÄini sline prema spolu. Rezultati pokazuju da su vrijednosti nestimulirane sline manje od vrijednosti stimulirane, C-vitamin poveÄava sekreciju za 35%, a āOrbitā za 70%. MuÅ”karci izluÄuju veÄe koliÄine nestimulirane sline i stimulirane C-vitaminom i āOrbitomā u odnosu na prema ženama i to u omjeru 1:1,5.ZvakaÄa se guma preporuÄuje u sijalometrijske i terapijske svrhe lokalne stimulacije.Stimulated and unstimulated saliva was quantified in 20 female and 20 male 5th year students of dentistry with healthy oral mucoous membranes and treated teeth. In the first measuring unstimulated saliva was determined by collecting in a test tube (0.1 scale) during 5 minutes. Stimulated saliva was measured 7 days later after drinking a water solution o f asorbic acid (Ig to ldcl), and collecting in a test tube during 5 minutes. After 14 days stimulated saliva was measured after chweing uOrbitā chewing gum for one minute and collecting in a test tube during 5 minutes. The aim o f the investigation was to determine the difference in the amount o f stimulated and unstimulated saliva; dependence o f saliva secretion on the type o f stimulation, and the difference in the amount o f saliva according to sex. The results show that the values o f unstimualted saliva are lower than the values o f stimulated saliva, and the C-vitamin increases secretion by 35%, and āOrbitā chewing gum by 70%. Male students excreted a greater quantity o f unstimulated saliva and saliva stimulated by C-vitamin and āOrbitā compored to the female students (ratio 1:1.5).Chewing gum is recommended for the purpose of sialographic and therapeutic local stimulation
Xerostomia: an Update
Kserostomija može znatno utjecati na oralno zdravlje i kvalitetu života. Mnogobrojne nove terapije stalno se razvijaju i vrjednuju, ali opÄenito i dalje se teÅ”ko lijeÄe bolesti žlijezda slinovnica smjeÅ”tenih u podlozi. Važno je kod svih bolesnika s dugotrajnom kserostomijom obaviti pretrage koje Äe otkriti uzrok i bolesnicima omoguÄiti odgovarajuÄu profesionalnu oralnu njegu.Xerostomia can have a significant adverse effect upon oral health and quality of life. A variety of new therapies are continuously being developed and assessed, but in general the treatment of the underlying salivary gland disease remains difficult. It is important, however, that all patients with long-standing xerostomia are appropriately investigated to establish the underlying aetiology, and to receive professional oral health care
Mandibular osteonecrosis due to the pulpal-periodontal syndrome: a case report and review of the literature
OBJECTIVE:
Ishemic bone disease has multifactorial etiologies. Cronic dental infections should be eliminated to prevent osteonecrosis of the jaw. -----
CASE REPORT:
We report an unusual case of osteonecrosis due to the pulpal-peridontal syndrome and subsequent pulp necrosis. A case of 38 year old woman who presented with exposed bone, 8 mm in diameter, in the lingual area of the right lower third molar. The patient was otherwise healthy and was not taking any medications. A detailed medical history showed no previous diseases. Patient denied any type of local trauma. A complete blood count showed no abnormalities. The panoramic radiograph revealed a deep periodontal pocket between teeth 47 and 48. The CBCT revealed a deep periodontal pocket between molars and bone sequestrum of the lingual plate. Topical treatment consisted of adhesive periodontal dressing based on the cellulose and bethamethasone oitnment together with orabase, without improvement. Therefore, peroral amoxycillin was prescribed for a week. Since there was no improvement, the third molar was removed as well as necrotic bone; the alveolar bone was remodelled and sutures were placed. After suturing, the whole area was covered using intraoral resorbable bandage. Microbial swab of the wound aspirate did not reveal polymorphonuclears or the presence of microorganisms. Microbial swab of the biopsy specimen of the necrotic bone particle and sequestrum showed a large amount of gram-positive coccae, however, polymorphonuclears were not found. Histopathological analysis revealed acute chronic inflammation. One week after the surgery, the area healed completely. -----
CONCLUSION:
This case highlights the fact that in some patients bone exposure might develop due to the pulpal-periodontal syndrome i.e. pulp necrosis
Quantity of Salivary Immunoglobulin A, Lysozyme and Magnesium in Patients with Burning Mouth Syndrome and Xerostomia
Nedavne studije izvjeÅ”Äuju o povezanosti izmeÄu sindroma peÄenja usta te koliÄine i sastava sline. Svrha naÅ”eg ispitivanja bila je ustanoviti koliÄinu salivarnog imunoglobulina A, lizozima i magnezija u nestimuliranoj i stimuliranoj ukupnoj slini bolesnika sa sindromom peÄenja usta (SPU) i kserostomijom. Uzorci sline dobiveni su sijalometrijom. Salivarni IgA je odreÄen radijalnom imunodifuzijom po Manziniju, koliÄina lizozima po metodi Osserman i Lowlor, a magnezij je odreÄen atomskom apsorpcijskom spektrofotometrijom. KoliÄina sIgA i lizozima bila je znatno snižena u stimuliranoj ukupnoj slini bolesnika sa SPU i kserostomijom u usporedbi s nestimuliranom (p<0,001). KoliÄina magnezija nije se mijenjala s obzirom na stimulaciju sline. Rezultati naÅ”eg ispitivanja pokazuju da koliÄina sline ima utjecaja na sastav sline te da zajedno mogu biti jedan od mnogobrojnih etioloÅ”kih Äimbenika u nastanku simptoma sindroma peÄenja usta.Recent studies suggest a connection between burning mouth syndrome (BMS) and the quantitiy and quality of saliva. The aim of our study was to determine quantities of salivary immunoglobulin A (sIgA), lysozyme and magnesium in unstimulated and stimulated saliva of patients with burning mouth syndrome and xerostomia. Salivary samples were obtained by sialometry. Salivary immunoglobulin A was determined by radial immunodiffusion according to Manzini, lysozyme levels were obtained according to Osserman and Lowlor, and magnesium was determined using atomic absorbance spectrophotometry. Levels of sIgA were decreased in stimulated whole saliva of patients with BMS and xerostomia when compared to those in unstimulated saliva (p<0.001). Lysozyme levels were also lower in stimulated whole saliva in such patients when compared to the levels in unstimulated saliva (p<0.001). Magnesium levels remain unchanged with regard to the salivary stimulation. The results of our study indicate that the quantity and quality of saliva could have an impact on symptoms of burning mouth syndrome
Connection Between the Course of Neurodermitis and Oral Focus Finding
U radu je opisan sluÄaj bolesnice koja boluje od neurodermitisa i u koje je potvrÄen nalaz oralnoga fokusa. PogorÅ”anje tijeka neurodermitisa koincidiralo je s otkriÄem oralnoga fokusa, a nakon eliminacije oralnoga fokusa stanje neurodermitisa se je poboljÅ”alo.A case of a patient suffering from neurodermitis, and with a finding of oral focus is described. The worsening of neurodermitis was concomitant with a finding of oral focus. After elimination of the focus, neurodermitis regressed from the severe form
Evaluation of Periodontal Status in HIV Infected Persons in Croatia
A number of periodontal changes have been associated with human immunodeficiency virus (HIV) infection, however
our knowledge of the epidemiology, microbiology, host response and natural history of these conditions remains limited.
Therefore, the aim of our study was the assessment of possible differences in periodontal status of HIV infected subjects
when compared with healthy controls matched for age, gender and smoking habit in Croatian population. Assessment
included measurement of plaque accumulation using aproximal plaque index, measurement of gingival inflammation
by use of sulcus bleeding index, pocket depth, gingival recession as well as the number of decayed, missing and filled
teeth in 25 HIV infected subjects (age range 22ā61, X=40.8 years) in comparison with 25 healthy controls (age range
20ā62, X=40.9 years). Statistical analysis was performed by use of descriptive statistics and Mann-Whitney U test showed
significantly increased level of inflammation of the marginal gingiva in HIV infected subjects when compared to the
controls (p<0.002). Significantly increased mean values of periodontal pockets (p<0.002) and the deepest periodontal
pocket (p<0.003) were also observed when HIV infected subjects were compared to the healthy controls. In HIV infected
subjects there was significant increase in the number of decayed, missing and decrease in the number of filled teeth
(p<0.002; p<0.002; p<0.009, respectively). The results of this study once again highlight the need for more prevalent
periodontal check-ups and treatments in HIV infected subjects
White Sponge Nevus
Opisan je sluÄaj 45-godiÅ”nje žene koja obostrano na obraznoj sluznici ima bijele hiperkeratotiÄne promjene. AnamnestiÄki podatci, kliniÄki nalaz te biopsijski nalaz u usnoj Å”upljini upuÄuju na dijagnozu bijelog spužvastog nevusa.A 45-year old woman was referred to our Department with bilateral white lesions on the buccal mucosa. Detailed medical history, clinical appearance including a histopathologic finding revealed a diagnosis of white sponge nevus
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