1 research outputs found
Electrospun Polyamide 6/Poly(allylamine hydrochloride) Nanofibers Functionalized with Carbon Nanotubes for Electrochemical Detection of Dopamine
The use of nanomaterials as an electroactive
medium has improved
the performance of bio/chemical sensors, particularly when synergy
is reached upon combining distinct materials. In this paper, we report
on a novel architecture comprising electrospun polyamide 6/polyÂ(allylamine
hydrochloride) (PA6/PAH) nanofibers functionalized with multiwalled
carbon nanotubes, used to detect the neurotransmitter dopamine (DA).
Miscibility of PA6 and PAH was sufficient to form a single phase material,
as indicated by thermogravimetric analysis (TGA) and differential
scanning calorimetry (DSC), leading to nanofibers with no beads onto
which the nanotubes could adsorb strongly. Differential pulse voltammetry
was employed with indium tin oxide (ITO) electrodes coated with the
functionalized nanofibers for the selective electrochemical detection
of dopamine (DA), with no interference from uric acid (UA) and ascorbic
acid (AA) that are normally present in biological fluids. The response
was linear for a DA concentration range from 1 to 70 μmol L<sup>–1</sup>, with detection limit of 0.15 μmol L<sup>–1</sup> (S/N = 3). The concepts behind the novel architecture to modify
electrodes can be potentially harnessed in other electrochemical sensors
and biosensors