Clinical characteristics and outcomes of systemic loxoscelism.

<p>Clinical characteristics and outcomes of systemic loxoscelism.</p

Significant findings for PheWAS of loxoscelism (adjusted significance level, <i>p</i> < 1.2 x 10⁻⁴).

<p>Significant findings for PheWAS of loxoscelism (adjusted significance level, <i>p</i> < 1.2 x 10⁻⁴).</p

Phenotypes and PheWAS of Individuals with Moderate-Severe Loxoscelism.

<p>(A) Manhattan plot representing the number of individuals with moderate to severe loxoscelism with each phenotype. The most frequent phenotypes validated the loxoscelism definition and included the toxic effect of venom, acquired hemolytic anemia, fever of unknown origin, and rash/skin eruption. (B) PheWAS for moderate-severe loxoscelism. The blue line represents significance level without correction (<i>p</i> = 0.05). The red line is representative of the adjusted significance threshold using the Bonferroni correction for multiple comparisons (<i>p =</i> 1.2 x 10⁻⁴). 29 phenotypes showed a significant correlation (p < 1.2 x 10⁻⁴) with the loxoscelism phenotype when compared to controls.</p