Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements

Glypican (GPC)-3 inhibits cell proliferation and regulates cell survival during development. This action is demonstrated by GPC3 loss-of-function mutations in humans and mice. Here, we show that the GPC3 core protein is processed by a furinlike convertase. This processing is essential for GPC3 modulating Wnt signaling and cell survival in vitro and for supporting embryonic cell movements in zebrafish. The processed GPC3 core protein is necessary and sufficient for the cell-specific induction of apoptosis, but in vitro effects on canonical and noncanonical Wnt signaling additionally require substitution of the core protein with heparan sulfate. Wnt 5A physically associates only with processed GPC3, and only a form of GPC3 that can be processed by a convertase is able to rescue epiboly and convergence/extension movements in GPC3 morphant embryos. Our data imply that the Simpson–Golabi–Behmel syndrome may in part result from a loss of GPC3 controls on Wnt signaling, and suggest that this function requires the cooperation of both the protein and the heparan sulfate moieties of the proteoglycan

Séance anatomo-clinique :Cancer bronchique et hémoptysie massive

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Circulating concentrations of interleukin-6 in cancer patients and their pathogenic role in tumor-induced hypercalcemia

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Clinical features of lung cancer

10th ERS Annual Congress, Florence, 30/08-03/09/2000info:eu-repo/semantics/publishedsuppl3

Natural killer-like T-cell lymphoma of the stomach

We report the case of a 69-year-old white woman who developed a natural killer (NK)-like T-cell lymphoma involving primarily the stomach. The tumour consisted of large and pleomorphic lymphocytes infiltrating the gastric mucosa. Immunohistochemistry performed on paraffin sections showed the neoplastic cells to be CD3+, CD5-, CD8-, CD43+, CD45RO+, and CD57+. In addition, these cells also expressed HLA-DR, granzyme B, and, to a lesser extent, the CD30 activation marker. No pathologic features suggesting Helicobacter pylori, Epstein-Barr virus infection, or lymphocytic gastritis were found within adjacent normal mucosa. The patient had no previous history of coeliac disease, and her serology for H. pylori was negative. Since lymphomas are usually considered the neoplastic counterpart of normal lymphocytic subsets, it is possible that in this case the tumour cells originate from a distinct cytotoxic T-cell population normally present within the gastric mucosa. The pathogenesis of this highly unusual neoplasm, however, remains a mystery.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Prognostic factors in lung cancer: Is protocol inclusion in patients with lung cancer an independant prognostic factor? A retrospective study

9th World Conference on Lung Cancer, 11-15/09/2000 (Japan)info:eu-repo/semantics/publishedsuppl 2: 12

Les facteurs pronostiques des cancers bronchiques: étude de populations traitées dans le cadre ou non d'un essai clinique de chimiothérapie

4e Congrès de Pneumologie de Langue Française, Nice, Acropolis, 26-29/01/2000info:eu-repo/semantics/publishedsuppl1: 1S39 (67)

L’inclusion dans un essai clinique est-il un facteur de mauvais pronostic pour la survie.

info:eu-repo/semantics/nonPublishe

Manifestations cliniques du cancer du poumon

Paris, cinquième congrès de pneumologie de langue françaiseinfo:eu-repo/semantics/publishe

Le rôle de l’expression du récepteur 1 du facteur de croissance de l’épithélium sur la survie des patients avec un cancer pulmonaire: une revue systématique de la littérature avec méta-analyse

20th Congress of the European Sleep Research Society, Lisbon ,Portugal, (14-18/09/2010)FLWNOinfo:eu-repo/semantics/publishe