Drugs prescribed for elderly oncologic patients hospitalized in the geriatric oncology unit of Institut Jules Bordet: polypharmacy and impact of clinical pharmacist.

info:eu-repo/semantics/nonPublishe

Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells

Is the concept of maternal tolerance preventing rejection of the semi-allogeneic 'fetal allograft' still valid?. Compilation of expert reviews of literature and recent advances in research on indoleamine-2,3 dioxygenase (IDO), regulatory T cells and galectin-1. A role for IDO in pregnancy success remains speculative, but solid data exist to support a role for Treg cells, and for galectin-1 in induction and action of Treg cells. Just as several signals may need to be simultaneously present to induce Th1 cytokine-triggered abortions, more than 1 signal may need to be simultaneously present to prevent rejection and ensure success. Both complement and coagulation pathways appear necessary for embryo execution.Fil: Terness, Peter. Universität Heidelberg; AlbaniaFil: Kallikourdes, Marinos. MRC Laboratory of Molecular Biology; Reino UnidoFil: Betz, Alexander G.. MRC Laboratory of Molecular Biology; Reino UnidoFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Saito, Shigeru. Universidad de Toyama; JapónFil: Clarck, David A.. Mc Master University; Canad