7 research outputs found
Modulation of Airway Epithelial Innate Immunity and Wound Repair by M(GM-CSF) and M(M-CSF) Macrophages
Airway epithelial cells and macrophages participate in inflammatory responses to external noxious stimuli, which can
cause epithelial injury. Upon injury, epithelial cells and macrophages act in concert to ensure rapid restoration of epithelial integrity. The nature of the interactions between
these cell types during epithelial repair is incompletely understood. We used an in vitro human coculture model of primary bronchial epithelial cells cultured at the air-liquid interface (ALI-PBEC) and polarized primary monocyte-derived
macrophages. Using this coculture, we studied the contribution of macrophages to epithelial innate immunity, wound
healing capacity, and epithelial exposure to whole cigarette
smok