Human Activity Behavior and Gesture Generation in Virtual Worlds for Long- Duration Space Missions

A virtual worlds presentation technique with embodied, intelligent agents is being developed as an instructional medium suitable to present in situ training on long term space flight. The system combines a behavioral element based on finite state automata, a behavior based reactive architecture also described as subsumption architecture, and a belief-desire-intention agent structure. These three features are being integrated to describe a Brahms virtual environment model of extravehicular crew activity which could become a basis for procedure training during extended space flight

The Relationship between Winds, Surface Roughness, and Radar Backscatter at Low Incidence Angles from TRMM Precipitation Radar Measurements

One year of collocated, rain-free normalized backscatter cross-section measurements from the Tropical Rainfall Mapping Mission (TRMM) precipitation radar (PR) and wind speed estimates from the TRMM Microwave Imager are used to construct fully empirical model functions relating cross section to wind speed for incidence angles from 0° (nadir) to 18°. With the exception of a ~1.9-dB offset, the TRMM PR model function at nadir compares well with TOPEX and Geosat results. For the first time using spaceborne data, least squares fits of the TRMM PR model functions to the geometric optics scattering formulation allow direct solution for the magnitudes and wind speed dependencies of Ku-band effective nadir reflectivity and effective mean square slope [s(u)]. Effective reflectivity is found to decrease slightly with increasing wind speed above 3.5 m s⁻¹. A logarithmic dependence of s(u) is found for wind speeds between 1 and 10 m s⁻¹. Both linear and two-branch logarithmic dependencies (with a slope break at 10 m s⁻¹) are excellent and statistically indistinguishable parameterizations for s(u) for wind speeds between 5 and 19 m s⁻¹. Calculations using the Elfouhaily et al. wave model suggest that the effective Ku-band s(u) corresponds to a cutoff wavelength of 3 to 6 times the radar wavelength for wind speeds from 5 to 25 m s⁻¹; at lower wind speeds, the cutoff wavelength increases rapidly consistent with earlier observations

Immunomic Investigation of Holocyclotoxins to Produce the First Protective Anti-Venom Vaccine Against the Australian Paralysis Tick, Ixodes holocyclus

Venom producing animals are ubiquitously disseminated among vertebrates and invertebrates such as fish, snakes, scorpions, spiders, and ticks. Of the ~890 tick species worldwide, 27 have been confirmed to cause paralysis in mammalian hosts. The Australian paralysis tick (Ixodes holocyclus) is the most potent paralyzing tick species known. It is an indigenous three host tick species that secretes potent neurotoxins known as holocyclotoxins (HTs). Holocyclotoxins cause a severe and harmful toxicosis leading to a rapid flaccid paralysis which can result in death of susceptible hosts such as dogs. Antivenins are generally polyclonal antibody treatments developed in sheep, horses or camels to administer following bites from venomous creatures. Currently, the methods to prevent or treat tick paralysis relies upon chemical acaricide preventative treatments or prompt removal of all ticks attached to the host followed by the administration of a commercial tick-antiserum (TAS) respectively. However, these methods have several drawbacks such as poor efficacies, non-standardized dosages, adverse effects and are expensive to administer. Recently the I. holocyclus tick transcriptome from salivary glands and viscera reported a large family of 19 holocyclotoxins at 38-99% peptide sequence identities. A pilot trial demonstrated that correct folding of holocyclotoxins is needed to induce protection from paralysis. The immunogenicity of the holocyclotoxins were measured using commercial tick antiserum selecting HT2, HT4, HT8 and HT11 for inclusion into the novel cocktail vaccine. A further 4 HTs (HT1, HT12, HT14 and HT17) were added to the cocktail vaccine to ensure that the sequence variation among the HT protein family was encompassed in the formulation. A second trial comparing the cocktail of 8 HTs to a placebo group demonstrated complete protection from tick challenge. Here we report the first successful anti-venom vaccine protecting dogs from tick paralysis

Revealing the Winds under the Rain. Part I: Passive Microwave Rain Retrievals Using a New Observation-Based Parameterization of Subsatellite Rain Variability and Intensity—Algorithm Description

Scatterometer ocean surface winds have been providing very valuable information to researchers and operational weather forecasters for over 10 years. However, the scatterometer wind retrievals are compromised when rain is present. Merely flagging all rain-affected areas removes the most dynamic and interesting areas from the wind analysis. Fortunately, the Advanced Earth Observing Satellite II (ADEOS-II) mission carried a radiometer [the Advanced Microwave Scanning Radiometer (AMSR)] and a scatterometer, allowing for independent, collocated retrievals of rain. The authors developed an algorithm that uses AMSR observations to estimate the rain inside the scatterometer beam. This is the first in a series of papers that describe their approach to providing rain estimation and correction to scatterometer observations. This paper describes the retrieval algorithm and evaluates it using simulated data. Part II will present its validation when applied to AMSR observations. This passive microwave rain retrieval algorithm addresses the issues of nonuniform beam filling and hydrometeor uncertainty in a novel way by 1) using a large number of soundings to develop the retrieval database, thus accounting for the geographically varying atmospheric parameters; 2) addressing the spatial inhomogeneity of rain by developing multiple retrieval databases with different built-in inhomogeneity and rain intensity, along with a ‘‘rain indicator’’ to select the most appropriate database for each observed scene; 3) developing a new cloud-versus-rain partitioning that allows the use of a variety of drop size distribution assumptions to account for some of the natural variability diagnosed from the soundings; and 4) retrieving atmospheric and surface parameters just outside the rainy areas, thus providing information about the environment to help decrease the uncertainty of the rain estimates.Keywords: Precipitation, Satellite observations, Algorithms, Radiative transfer, Microwave observations, Remote sensin

Statistics of tricoherence

Statistics of the estimates of tricoherence are obtained analytically for nonlinear harmonic random processes with known true tricoherence. Expressions are presented for the bias, variance, and probability distributions of estimates of tricoherence as functions of the true tricoherence and the number of realizations averaged in the estimates. The expressions are applicable to arbitrary higher order coherence and arbitrary degree of interaction between modes. Theoretical results are compared with those obtained from numerical simulations of nonlinear harmonic random processes. Estimation of true values of tricoherence given observed values is also discusse

Performance characteristics of an enzyme-linked immunosorbent assay performed in milk for the detection of liver fluke (Fasciola hepatica) infection in cattle

Aim: To determine the performance characteristics of an enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies against liver fluke (Fasciola hepatica) in bovine milk. Methods: Serum and milk from liver fluke infected and non-infected cattle was assayed in a commercially available enzyme-linked immunosorbent assay. Serum test results were used to determine the “gold standard” infection status of cattle and milk ELISA results assessed by ROC analysis. Results: ROC analysis suggested changes to the ELISA protocol, arriving at milk dilutions assayed considerably higher than those suggested by the manufacturer. With those changes, the ELISA performed with high sensitivity and specificity, 95 and 98.2%, respectively, for individual bovine milks (relative to sera). For bovine tank milks, sensitivity was lower, with bulk milks only testing positive if 60% or more of cattle milking in the herd were infected. Conclusions: The analysis of the ELISA's performance when used on individual bovine milks demonstrated high sensitivity and specificity. ROC analyses optimised the assay conditions and cut-off point suggested by the manufacturer for this commercial diagnostic assay. This would help with the identification and control of fasciolosis, enabling simpler sample collection.M.P. Reichel, K. Vanhoff and B. Baxte

Cryptosporidium Vaccine Trial using Recombinant Sporozoite GP40/15 Antigen

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