NIVO I TEMPO REGIONALNOG RAZVOJA BOSNE I HERCEGOVINE U KONTEKSTU INTEGRIRANJA U EUROPSKU UNIJU

The main goal of this paper is to assess the level and pace of regional development of Bosnia and Herzegovina on the one hand, and the Euro-Atlantic path of Bosnia and Herzegovina as a potential candidate for EU membership on the other. In the empirical part of the research, the spatial component encompassed the regionalization of Bosnia and Herzegovina. The research also included an analysis of the process of the integration of Bosnia and Herzegovina into the European Union from the aspect of preaccession assistance to candidate countries and potential candidates in the function of promoting regional development. The primary research of regional development and assessment of the level of development as well as the scope of structural policies in overcoming the key political, social and economic problems that hinder the development and improvement of the economic integration of Bosnia and Herzegovina towards the European Union are limited to the territory of Bosnia and Herzegovina. The basic scientific methods used in the work and for giving answers to research questions are historical and comparative methods. They consist of methods and indicators of statistical analysis (indices, growth rates, participation rates, coefficients, averages). Specific scientific methods used in the process of this work are: the method of analysis, the synthesis method, the induction method, the descriptor method, the deduction method, the classification method and the comparison method. The empirical results of the research confirm that Bosnia and Herzegovina is faced with the problem of regional development with a pronounced imbalance between the areas within the whole territory of Bosnia and Herzegovina. This is a confirmation for the need for systemic policy as well as regional development policy at the level of Bosnia and Herzegovina that would be in line with the policies of the European Union.Glavni cilj ovog rada je ocjena nivoa i tempa regionalnog razvoja Bosne i Hercegovine sa jedne strane, te euroatlanski put BiH kao potencijalni kandidat za članstvo u Uniju sa druge strane. U empirijskom dijelu istraživanja prostorna komponenta obuhvatila je regionalizaciju Bosne i Hercegovine. Istraživanje je obuhvatilo i analizu procesa integriranja Bosne i Hercegovine u Evropsku uniju sa aspekta pretpristupne pomoći zemljama kandidatima i potencijalnim kandidatima u funkciji unapređenja regionalnog razvoja. Primarno istraživanje regionalnog razvoja i ocjene nivoa razvijenosti kao i obuhvat strukturnih politika u pogledu nadilaženja ključnih političkih, društvenih i ekonomskih problema, koji koče razvoj i unapređenje ekonomske integracije BiH prema Evropskoj uniji ograničeni su na teritoriju BiH. Osnovne naučne metode, korištene u radu i davanja odgovora na istraživačka pitanja su historijska i komparativna metoda. Sastoje se od metoda i pokazatelja statističke analize (indeksi, stope rasta, pokazatelji učeća, koeficijenti, prosjeci). Posebne naučne metode korištene u postupku radu su: metoda analize, metoda sinteze, metoda indukcije, metoda deskripcije, metoda dedukcije, metoda klasifikacije, metoda komparacije. Empirijskim rezultatima istraživanja potvrđuje se da je Bosna i Hercegovina suočena sa problemom regionalnog razvoja sa izraženim debalansom među područjima unutar cijele teritorije BiH. To potvrđuje potrebu sistemske politike kao i politike regionalnog razvoja na nivou Bosne i Hercegovine koja bi bila usklađena sa politikama Evropske unije

Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome

Down syndrome (DS) is a genetic disorder arising from the presence of a third copy of the human chromosome 21 (Hsa21). Recently, O’Doherty and colleagues in an earlier study generated a new genetic mouse model of DS (Tc1) that carries an almost complete Hsa21. Since DS is the most common genetic cause of mental retardation, we have undertaken a detailed analysis of cognitive function and synaptic plasticity in Tc1 mice. Here we show that Tc1 mice have impaired spatial working memory (WM) but spared long-term spatial reference memory (RM) in the Morris watermaze. Similarly, Tc1 mice are selectively impaired in short-term memory (STM) but have intact long-term memory (LTM) in the novel object recognition task. The pattern of impaired STM and normal LTM is paralleled by a corresponding phenotype in long-term potentiation (LTP). Freely-moving Tc1 mice exhibit reduced LTP 1 h after induction but normal maintenance over days in the dentate gyrus of the hippocampal formation. Biochemical analysis revealed a reduction in membrane surface expression of the AMPAR (α-amino-3-hydroxy-5-methyl-4-propionic acid receptor) subunit GluR1 in the hippocampus of Tc1 mice, suggesting a potential mechanism for the impairment in early LTP. Our observations also provide further evidence that STM and LTM for hippocampus-dependent tasks are subserved by parallel processing streams

Primjena Rasch modeliranja u analizi netočnih odgovora studenata na pitanja višestrukog izbora: Primjer iz valne optike

An analysis of students’ difficulties for a curricular topic may help the educator to gain better insight into students’ reasoning about that topic which is a prerequisite for high-quality teaching. The purpose of this study was to demonstrate how distractor analysis may be used for identifying students’ difficulties in a certain topic. In order to be in position to perform invariant measurement and to easily relate students’ difficulties to their achievement levels, we decided to take a Rasch modeling approach. Our study included 14 wave optics items and 286 students from five universities in Slovenia, Croatia, and Bosnia and Herzegovina. Rasch modeling was used to estimate item and student measures, as well as to create option probability curves which allowed us to relate students’ achievement levels to the choice of individual distractors. It has been found that all 14 included items function in line with the Rasch model. In 10 out of 14 items there were distractors chosen by at least 25% of students. For several out of these 10 items, the option probability curves indicated that attractiveness of individual distractors depended on students’ ability levels. We could conclude that the Rasch-based distractor analysis may provide very useful information for differentiation of physics instruction.Analiza studentskih poteškoća vezanih za određenu nastavnu temu može pomoći predavaču u stjecanju boljeg uvida u studentsko razumijevanje određene teme, što je preduvjet za visokokvalitetnu nastavu. Svrha ovog istraživanja sastojala se u demonstriranju načina na koji analize ometača mogu biti iskorištene za identificiranje studentskih poteškoća u određenom području. Kako bismo mogli provoditi invarijantna mjerenja i lako povezati studentske poteškoće s razinama njihovih postignuća, odlučili smo se studiju provesti u okviru Rasch formalizma. Naše istraživanje obuhvatilo je 14 zadataka iz područja valne optike i 286 studenata s pet sveučilišta u Sloveniji, Hrvatskoj te Bosni i Hercegovini. Rasch modeliranje korišteno je za procjenu težine zadataka i sposobnosti studenata, kao i za kreiranje krivulja vjerojatnosti ponuđenih opcija što nam je omogućilo povezivanje razine razumijevanja studenata s izborom pojedinačnih ometača. Utvrđeno je da svih 14 zadataka funkcionira u skladu s Rasch modelom. Za 10 zadataka imali smo ometače koje je odabralo najmanje 25 % studenata. Kod nekoliko od ovih 10 zadataka krivulje vjerojatnosti ponuđenih opcija ukazuju na to da atraktivnost pojedinačnih ometača ovisi o razinama sposobnosti učenika. Možemo zaključiti da analiza ometača primjenom Rasch modeliranja može dati vrlo korisne informacije za diferencijaciju nastave fizike

Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome

Down syndrome (DS) is a genetic disorder arising from the presence of a third copy of human chromosome 21 (Hsa21). Recently, O’Doherty et al. [An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science 309 (2005) 2033–2037] generated a trans-species aneuploid mouse line (Tc1) that carries an almost complete Hsa21. The Tc1 mouse is the most complete animal model for DS currently available. Tc1 mice show many features that relate to human DS, including alterations in memory, synaptic plasticity, cerebellar neuronal number, heart development and mandible size. Because motor deficits are one of the most frequently occurring features of DS, we have undertaken a detailed analysis of motor behaviour in cerebellum-dependent learning tasks that require high motor coordination and balance. In addition, basic electrophysiological properties of cerebellar circuitry and synaptic plasticity have been investigated. Our results reveal that, compared with controls, Tc1 mice exhibit a higher spontaneous locomotor activity, a reduced ability to habituate to their environments, a different gait and major deficits on several measures of motor coordination and balance in the rota rod and static rod tests. Moreover, cerebellar long-term depression is essentially normal in Tc1 mice, with only a slight difference in time course. Our observations provide further evidence that support the validity of the Tc1 mouse as a model for DS, which will help us to provide insights into the causal factors responsible for motor deficits observed in persons with DS

The structure of a minimal nn-chart with two crossings II: Neighbourhoods of Γ1∪Γn−1\Gamma_1\cup\Gamma_{n-1}

Given a 2-crossing minimal chart $\Gamma$, a minimal chart with two crossings, set $\alpha=\min\{~i~|~$there exists an edge of label $i$ containing a white vertex$\}$, and $\beta=\max\{~i~|~$there exists an edge of label $i$ containing a white vertex$\}$. In this paper we study the structure of a neighbourhood of $\Gamma_\alpha\cup\Gamma_\beta$, and propose a normal form for 2-crossing minimal $n$-charts, here $\Gamma_\alpha$ and $\Gamma_\beta$ mean the union of all the edges of label $\alpha$ and $\beta$ respectively.Comment: 57 pages, 36 figure

The feel good factor at work

KUCHING: The Inland Revenue Board (IRB) tax collection target of RM130bil this year could be revised upwards

A safe haven for the young: Psychiatric evaluation for children home's residents meant to address their mental, emotional health

KUCHING; It is imperative for children placed at the Rumah Kanak-Kanak Kuching to undergo psychiatric evaluation to ascertain the status of their emotion and mental well being, said the home's principal Armisy Basri

The "other" trace DNA - forensic STR typing of ancient human remains and environmental samples left by non-human primates

Poster presented at Human Identification Solutions (HIDS) 2017, 16th-17th May, 2017, Vienna, Austria