Towards robust and reliable multimedia analysis through semantic integration of services

Thanks to ubiquitous Web connectivity and portable multimedia devices, it has never been so easy to produce and distribute new multimedia resources such as videos, photos, and audio. This ever-increasing production leads to an information overload for consumers, which calls for efficient multimedia retrieval techniques. Multimedia resources can be efficiently retrieved using their metadata, but the multimedia analysis methods that can automatically generate this metadata are currently not reliable enough for highly diverse multimedia content. A reliable and automatic method for analyzing general multimedia content is needed. We introduce a domain-agnostic framework that annotates multimedia resources using currently available multimedia analysis methods. By using a three-step reasoning cycle, this framework can assess and improve the quality of multimedia analysis results, by consecutively (1) combining analysis results effectively, (2) predicting which results might need improvement, and (3) invoking compatible analysis methods to retrieve new results. By using semantic descriptions for the Web services that wrap the multimedia analysis methods, compatible services can be automatically selected. By using additional semantic reasoning on these semantic descriptions, the different services can be repurposed across different use cases. We evaluated this problem-agnostic framework in the context of video face detection, and showed that it is capable of providing the best analysis results regardless of the input video. The proposed methodology can serve as a basis to build a generic multimedia annotation platform, which returns reliable results for diverse multimedia analysis problems. This allows for better metadata generation, and improves the efficient retrieval of multimedia resources

Using EPUB 3 and the open web platform for enhanced presentation and machine-understandable metadata for digital comics

Various methods are needed to extract information from current (digital) comics. Furthermore, the use of different (proprietary) formats by comic distribution platforms causes an overhead for authors. To overcome these issues, we propose a solution that makes use of the EPUB 3 specification, additionally leveraging the Open Web Platform to support animations, reading assistance, audio and multiple languages in a single format, by using our JavaScript library comicreader.js. We also provide administrative and descriptive metadata in the same format by introducing a new ontology: Dicera. Our solution is complementary to the current extraction methods, on the one hand because they can help with metadata creation, and on the other hand because the machine-understandable metadata alleviates their use. While the reading system support for our solution is currently limited, it can offer all features needed by current comic distribution platforms. When comparing comics generated by our solution to EPUB 3 textbooks, we observed an increase in file size, mainly due to the use of images. In future work, our solution can be further improved by extending the presentation features, investigating different types of comics, studying the use of new EPUB 3 extensions, and by incorporating it in digital book authoring environments

Systematic development of an evidence-based website on preconception care

Introduction: In February 2015, the Flemish Minister of Welfare, Public Health and Family launched a website on preconception care: gezondzwangerworden.be'. The website was developed in response to the lack of comprehensive communication on preconception care and the inadequate intake of folic acid among Flemish women. Despite the international recommendation to take 400g folic acid on a daily basis one month before conception until 12 weeks of pregnancy, studies show a lack of compliance in women wanting to become pregnant. Procedure: A compilation of evidence was made through reviewing well-established guidelines on preconception and prenatal care. The quality of guidelines was assessed by means of AGREE II. The topics included in the website were selected by an internal committee of 5 experts and an external committee of 16 experts. Content validation was carried out by 40 experts in preconception care or related topics. Results: The above-described procedure resulted in an evidence-based website with a selection of relevant, validated information for both women and men who plan a pregnancy and professionals who are consulted by these people. Evaluation and recommendation: The website is currently attracting a constant number of 100 to 200 visitors a day. The information on folic acid is among the most requested, which is an important finding with regard to the policy objectives on preconception care. More research is needed in order to evaluate the use and effect of the website more thoroughly

Dose rationale and pharmacokinetics of dexmedetomidine in mechanically ventilated new-borns : impact of design optimisation

Purpose: There is a need for alternative analgosedatives such as dexmedetomidine in neonates. Given the ethical and practical difficulties, protocol design for clinical trials in neonates should be carefully considered before implementation. Our objective was to identify a protocol design suitable for subsequent evaluation of the dosing requirements for dexmedetomidine in mechanically ventilated neonates. Methods: A published paediatric pharmacokinetic model was used to derive the dosing regimen for dexmedetomidine in a first-in-neonate study. Optimality criteria were applied to optimise the blood sampling schedule. The impact of sampling schedule optimisation on model parameter estimation was assessed by simulation and re-estimation procedures for different simulation scenarios. The optimised schedule was then implemented in a neonatal pilot study. Results: Parameter estimates were more precise and similarly accurate in the optimised scenarios, as compared to empirical sampling (normalised root mean square error: 1673.1% vs. 13,229.4% and relative error: 46.4% vs. 9.1%). Most importantly, protocol deviations from the optimal design still allowed reasonable parameter estimation. Data analysis from the pilot group (n = 6) confirmed the adequacy of the optimised trial protocol. Dexmedetomidine pharmacokinetics in term neonates was scaled using allometry and maturation, but results showed a 20% higher clearance in this population compared to initial estimates obtained by extrapolation from a slightly older paediatric population. Clearance for a typical neonate, with a post-menstrual age (PMA) of 40 weeks and weight 3.4 kg, was 2.92 L/h. Extension of the study with 11 additional subjects showed a further increased clearance in pre-term subjects with lower PMA. Conclusions: The use of optimal design in conjunction with simulation scenarios improved the accuracy and precision of the estimates of the parameters of interest, taking into account protocol deviations, which are often unavoidable in this event-prone population