Noninvasive evaluation of patients with coronary artery disease and heart failure

In dit proefschrift worden patiënten bestudeerd met een voorgeschiedenis van coronair lijden en hartfalen. De thesis is onderverdeeld in drie delen: 1. Niet-invasieve inschatting van vuldrukken door middel van geavanceerde echocardiografische technieken 2. Selectie van kandidaten voor cardiale resynchronizatietherapie met echocardiografie, nucleaire technieken en multi slice CT 3. Nietinvasieve prognostische markers waaronder nuchtere glycemie en determinanten van inspanningscapacitei

Design and evaluation of an architecture for future smart grid service provisioning

In recent years, there has been a growing interest in cloud technologies. Using current cloud solutions, it is however difficult to create customizable multi-tenant applications, especially if the application must support varying Quality of Service (QoS) guarantees. Software Product Line Engineering (SPLE) and feature modeling techniques are commonly used to address these issues in non-cloud applications, but these techniques cannot be ported directly to a cloud context, as the common approaches are geared towards customization of on-premise deployed applications, and do not support multi-tenancy. In this paper, we propose an architecture for the development and management of customizable Software as a Service (SaaS) applications, built using SPLE techniques. In our approach, each application is a composition of services, where individual services correspond to specific application functionalities, referred to as features. A feature-based methodology is described to abstract and convert the application information required at different stages of the application life-cycle: development, customization and deployment. We specifically focus on how development feature models can be adapted ensuring a one-to-one correspondence between features and services exists, ensuring the composition of services yields an application containing the corresponding features. These runtime features can then be managed using feature placement techniques. The proposed approach enables developers to define significantly less features, while limiting the amount of automatically generated features in the application runtime stage. Conversion times between models are shown to be in the order of milliseconds, while execution times of management algorithms are shown to improve by 5 to 17% depending on the application case

Si-photonic integrated PZT thin film for acousto-optic modulation

We demonstrate optical phase modulation in a Si waveguide by generation of surface acoustic wave using Lead Zirconate Titanate (PZT) thin film. Our measurement shows a V pi L approximate to 3.35 V cm before any device-optimization. (C) 2020 The Author(s

Light modulation in Silicon photonics by PZT actuated acoustic waves

Tailoring the interaction between light and sound has opened new possibilities in photonic integrated circuits (PICs) that ranges from achieving quantum control of light to high-speed information processing. However, the actuation of sound waves in Si PICs usually requires integration of a piezoelectric thin film. Lead Zirconate Titanate (PZT) is a promising material due to its strong piezoelectric and electromechanical coupling coefficient. Unfortunately, the traditional methods to grow PZT on Silicon are detrimental for photonic applications due to the presence of an optical lossy intermediate layer. In this work, we report integration of a high quality PZT thin film on a Silicon-on-insulator (SOI) photonic chip using an optically transparent buffer layer. We demonstrate acousto-optic modulation in Silicon waveguides with the PZT actuated acoustic waves. We fabricate inter digital transducers (IDTs) on the PZT film with a contact photo-lithography and electron-beam lithography to generate the acoustic waves in MHz and GHz range respectively. We obtain a V$_{\pi}$L $\sim$ 3.35 V$\cdot$cm at 576 MHz from a 350 nm thick gold (Au) IDT with 20 finger-pairs. After taking the effect of mass-loading and grating reflection into account, we measured a V$_{\pi}$L $\sim$ 3.60 V$\cdot$cm at 2 GHz from a 100 nm thick Aluminum (Al) IDT consisting of only 4 finger-pairs. Thus, without patterning the PZT film nor suspending the device, we obtained figures-of-merit comparable to state-of-the-art modulators based on SOI, making it a promising candidate for broadband and efficient acousto-optic modulator for future integration

In-plane characterization of PZT thin films for the creation of a general impedance model

The in-plane dielectric and ferroelectric properties of preferentially oriented lead zirconate titanate (PZT) thin films are characterized using interdigitated transducers (IDTs). By combining finite element method simulations and capacitance measurements, values of the dielectric constant of films with thicknesses between 150 nm and 800 nm are obtained. A modified Sawyer–Tower circuit is used to investigate the polarization loops measured in-plane using IDT electrodes. A well-defined hysteresis loop is obtained demonstrating the switching of the polarization of the ferroelectric domains. Leakage current measurements reveal high resistivity and are an indication of the high quality of the PZT film. The obtained characteristics are used to determine the total impedance of the IDT-PZT structure. Here, the structure is represented by an equivalent ladder circuit using the inductance and resistance of the IDT electrodes and the capacitance and conductance of the PZT film. The obtained total impedance matches low frequency measurements

Non-Invasive Visualization of the Cardiac Venous System in Coronary Artery Disease Patients Using 64-Slice Computed Tomography

ObjectivesThis study was designed to evaluate the value of 64-slice computed tomography (CT) to visualize the cardiac veins and evaluate the relation between variations in venous anatomy and history of infarction.BackgroundCardiac resynchronization therapy (CRT) is an attractive treatment for selected heart failure patients. Knowledge of venous anatomy may help in identifying candidates for successful left ventricular lead implantation.MethodsThe 64-slice CT of 100 individuals (age 61 ± 11 years, 68% men) was studied. Subjects were divided into 3 groups: 28 control patients, 38 patients with significant coronary artery disease (CAD), and 34 patients with a history of infarction. Presence of the following coronary sinus (CS) tributaries was evaluated: posterior interventricular vein (PIV), posterior vein of the left ventricle, and left marginal vein (LMV). Vessel diameters were also measured.ResultsCoronary sinus and PIV were identified in all individuals. Posterior vein of the left ventricle was observed in 96% of control patients, 84% of CAD patients, and 82% of infarction patients. In patients with a history of infarction, a LMV was significantly less observed as compared with control patients and CAD patients (27% vs. 71% and 61%, respectively, p < 0.001). None of the patients with lateral infarction and only 22% of patients with anterior infarction had a LMV. Regarding quantitative data, no significant differences were observed between the groups.ConclusionsNon-invasive evaluation of cardiac veins with 64-slice CT is feasible. There is considerable variation in venous anatomy. Patients with a history of infarction were less likely to have a LMV, which may hamper optimal left ventricular lead positioning in CRT implantation