Dexterity in the Acute Phase of Stroke: Impairments and Neural Substrates.

Stroke can impair manual dexterity, leading to loss of independence following incomplete recovery. Enhancing our understanding of dexterity impairment may improve neurorehabilitation. The study aimed to measure dexterity components in acute stroke patients with and without hand motor deficits, compare them to those of healthy controls (HC), and to explore the neural substrates involved in specific components of dexterity. We used the Dextrain Manipulandum to quantify fine finger force control, finger selection accuracy, coactivation, and reaction time (RT). Dexterity was evaluated twice (2 days apart) in 74 patients and 14 HC. Voxel-Lesion-Symptom-Mapping (VLSM) was used to analyze the relationship between tissue damage and dexterity. Due to severe paresis or fatigue, 24 patients could not perform these tasks. In 50 patients (included 4.6 ± 3.3 days post-stroke), finger force control improved ( < .001), as it did in HC ( = .03) who performed better than patients on both evaluations. Accuracy of finger selection did not improve significantly in any group, but the HC performed better on both evaluations. Unexpectedly, coactivation was better in patients than in HC at D3 ( = .03). There were no between-group differences in RT. VLSM showed that damage to the superior temporal gyrus (STG) impaired finger force control while damage to the posterior limb of the internal capsule (PLIC) impaired finger selectivity. Acute stroke affecting the STG or PLIC impaired selective components of dexterity. Patients with mild to moderate impairment showed better finger force control and accuracy selection within 48 hours, suggesting the feasibility of detecting early dexterity improvements

sj-docx-4-nnr-10.1177_15459683241230029 – Supplemental material for Dexterity in the Acute Phase of Stroke: Impairments and Neural Substrates

Supplemental material, sj-docx-4-nnr-10.1177_15459683241230029 for Dexterity in the Acute Phase of Stroke: Impairments and Neural Substrates by Eloïse Gerardin, Maxime Regnier, Laurence Dricot, Julien Lambert, Coralie van Ravestyn, Béatrice De Coene, Benoît Bihin, Påvel Lindberg and Yves Vandermeeren in Neurorehabilitation and Neural Repair</p

sj-jpg-1-nnr-10.1177_15459683241230029 – Supplemental material for Dexterity in the Acute Phase of Stroke: Impairments and Neural Substrates

Supplemental material, sj-jpg-1-nnr-10.1177_15459683241230029 for Dexterity in the Acute Phase of Stroke: Impairments and Neural Substrates by Eloïse Gerardin, Maxime Regnier, Laurence Dricot, Julien Lambert, Coralie van Ravestyn, Béatrice De Coene, Benoît Bihin, Påvel Lindberg and Yves Vandermeeren in Neurorehabilitation and Neural Repair</p

sj-jpeg-3-nnr-10.1177_15459683241230029 – Supplemental material for Dexterity in the Acute Phase of Stroke: Impairments and Neural Substrates

Supplemental material, sj-jpeg-3-nnr-10.1177_15459683241230029 for Dexterity in the Acute Phase of Stroke: Impairments and Neural Substrates by Eloïse Gerardin, Maxime Regnier, Laurence Dricot, Julien Lambert, Coralie van Ravestyn, Béatrice De Coene, Benoît Bihin, Påvel Lindberg and Yves Vandermeeren in Neurorehabilitation and Neural Repair</p

sj-jpg-2-nnr-10.1177_15459683241230029 – Supplemental material for Dexterity in the Acute Phase of Stroke: Impairments and Neural Substrates

Supplemental material, sj-jpg-2-nnr-10.1177_15459683241230029 for Dexterity in the Acute Phase of Stroke: Impairments and Neural Substrates by Eloïse Gerardin, Maxime Regnier, Laurence Dricot, Julien Lambert, Coralie van Ravestyn, Béatrice De Coene, Benoît Bihin, Påvel Lindberg and Yves Vandermeeren in Neurorehabilitation and Neural Repair</p

sj-docx-1-nnr-10.1177_15459683241245416 – Supplemental material for Post-Stroke Impairments of Manual Dexterity and Finger Proprioception: Their Contribution to Upper Limb Activity Capacity

Supplemental material, sj-docx-1-nnr-10.1177_15459683241245416 for Post-Stroke Impairments of Manual Dexterity and Finger Proprioception: Their Contribution to Upper Limb Activity Capacity by Coralie van Ravestyn, Eloïse Gerardin, Maxime Térémetz, Sonia Hamdoun, Jean-Claude Baron, David Calvet, Yves Vandermeeren, Guillaume Turc, Marc A. Maier, Charlotte Rosso, Jean-Louis Mas, Lucile Dupin and Påvel G. Lindberg in Neurorehabilitation and Neural Repair</p