Development of cystic periventricular leukomalacia in newborn infants after rotavirus infection.

We describe 5 preterm and 3 term infants who presented with seizures during rotavirus infection within 6 weeks after birth. Six of these infants developed late-onset cystic periventricular leukomalacia. Four of the preterm infants had neurodevelopmental delay, and 4 (near) term infants had normal early outcome

Indução de resistência a doenças foliares em tomateiro por indutores biótico (Bacillus subtilis) e abiótico (Acibenzolar-S-Metil) Induction of resistance in tomato by biotic (Bacillus subtilis) and abiotic (Acibenzolar-S-Metil) inducers

O objetivo deste trabalho foi investigar se doenças foliares do tomateiro (Lycopersicon esculentum) podem ser afetadas pela indução de resistência proporcionada pela aplicação de Bacillus subtilis, no solo e nas folhas e aplicação via foliar de acibenzolar-S-metil. A fim de investigar o modo de ação envolvido no controle foi avaliada a atividade de peroxidases nas folhas do tomateiro tratado com os indutores biótico e abiótico. Para se avaliar a severidade das doenças foliares foi avaliado o número de folhas de tomate com algum sintoma de doença e determinado o percentual de folhas doentes em relação ao total de folhas por planta. O aumento significativo da concentração de peroxidases nas plantas tratadas com os indutores, assim como a ausência de controle das doenças no tratamento com pulverização direta de B. subtilis nas folhas, são evidências que sugerem que o mecanismo de controle das doenças em questão está relacionado à resistência induzida.<br>This study was conduced to investigate whether the tomato (Lycopersicon esculentum) leaf diseases may be affected by the induction of resistance provided by the application of Bacillus subtilis, soil and leaf and foliar application of Acibenzolar-S-Methyl. In order to investigate the mode of action involved in the control was measured the peroxidases activity in the leaf of tomato treated with inducers biotic and abiotic. To evaluate the severity of foliar diseases has been estimated the number of leaf of tomatoes with symptoms of disease and determinate the percent of disease leaf in the total of leaf per plant. The significant increase in levels of peroxidase activity in plants exposed to treatment with inducers and lack of control of leaf diseases, in direct spray of B. subtilis in the leaves, are evidence that suggest that the mechanism of control diseases in question is related to induction resistance

Novel FOXF1 Mutations in Sporadic and Familial Cases of Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins Imply a Role for its DNA Binding Domain.

Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a rare and lethal developmental disorder of the lung defined by a constellation of characteristic histopathological features. Nonpulmonary anomalies involving organs of gastrointestinal, cardiovascular, and genitourinary systems have been identified in approximately 80% of patients with ACD/MPV. We have collected DNA and pathological samples from more than 90 infants with ACD/MPV and their family members. Since the publication of our initial report of four point mutations and 10 deletions, we have identified an additional 38 novel nonsynonymous mutations of FOXF1 (nine nonsense, seven frameshift, one inframe deletion, 20 missense, and one no stop). This report represents an up to date list of all known FOXF1 mutations to the best of our knowledge. Majority of the cases are sporadic. We report four familial cases of which three show maternal inheritance, consistent with paternal imprinting of the gene. Twenty five mutations (60%) are located within the putative DNA-binding domain, indicating its plausible role in FOXF1 function. Five mutations map to the second exon. We identified two additional genic and eight genomic deletions upstream to FOXF1. These results corroborate and extend our previous observations and further establish involvement of FOXF1 in ACD/MPV and lung organogenesis

Thermodynamic and kinetic study of diffusion paths in the system Cu-Fe-Ni

An understanding and modeling of diffusion paths in ternary systems requires a combined thermodynamic and diffusion kinetic approach. The driving force for the intrinsic diffusion of each component is the gradient of the chemical potential (or activity) which can be calculated from the concentration profile if the thermodynamic properties of the system are known. For studying the diffusion behavior in ternary metallic systems, the Cu-Fe-Ni-system was chosen because of its experimental and thermodynamic simplicity. Concentration profiles and diffusion paths in single-phase areas and across an a/ß interface were studied experimentally at 1000 °C using the diffusion couple technique. Coefficients for interdiffusion and tracer diffusion have been calculated at the intersection points of two independent diffusion paths with a common composition. A concentration dependence for the tracer diffusion coefficients for each component was calculated and found to be consistent with the literature data in the binary Cu-Ni and Fe-Ni systems. The calculated vacancy flux in the couples was consistent with the experimentally observed marker shift