Novel ultrasound-contrast-agent dilution method for assessment of left ventricular ejection faction

Background: Left ventricular ejection fraction (LVEF) is an important determinant of prognosis. We evaluated the accuracy of a novel fast method for LVEF quantification based on indicator dilution curve (IDC) principles (figure 1) and compared the results with contrast-enhanced biplane LVEF assessment. Method: a 10 ml diluted (1:100) ultrasound-contrast bolus (SonoVue ®) was injected intravenously in thirty patients (pts) (20 male, age 65 ± 10) with known or suspected heart disease. In 22 pts multiple recordings were made and in 12 pts injections were repeated after implantation of a biventricular pacemaker, leading to 68 measurements. The developed algorithm used the left atrium and LV IDC for the LVEF measurement. For the biplane enhanced LVEF measurements a 0.5 ml pure ultrasound-contrast bolus (SonoVue ®) was administered to obtain multiple four- and two-chamber recordings. Results: according to contrast enhanced biplane assessments, the LVEF ranged from 10 to 75 % while the LV end-diastolic volume ranged from 80 to 521 ml. The mean LVEF measured by the biplane and the IDC method was 33 ± 17 % and 35 ± 18 %, respectively. A correlation coefficient r=0.91 was observed between the two methods (figure 2). Conclusion: A new fast method for LVEF assessment based on IDC principles is described and comparison with contrast enhanced biplane LVEF quantification shows accurate results. The proposed method also allows simultaneous quantification of right ventricular EF based on the same IDC principles

Novel ultrasound contrast agent dilution method for the assessment of ventricular ejection fraction

Aims: Left ventricular (LV) ejection fraction is an important determinant of prognosis in heart failure. We evaluated the accuracy of a novel algorithm for LV ejection fraction quantification based on indicator dilution curve (IDC) principles using ultrasound contrast as indicator, and compared the results with contrast enhanced biplane LV ejection fraction assessment. Method: A diluted ultrasound contrast bolus (SonoVue®) was injected intravenously in 31 patients (19 male, age 65 ± 11) with known or suspected heart disease. A total of 68 recordings were made. The developed algorithm used the left atrium and LV IDC for LV ejection fraction measurement. Biplane enhanced LV ejection fraction measurements with pure ultrasound contrast (SonoVue®) were determined in multiple four- and two-chamber recordings as reference. Results: The mean LV ejection fraction measured by biplane and IDC method was 33 ± 17% and 35 ± 18%, respectively. A correlation coefficient r = 0.93 was observed between the two methods. Bland–Altman analysis demonstrated a slight LV ejection fraction overestimation with IDC (mean 1.9 ± 6.3%). Conclusion: A new fast method for LV ejection fraction assessment based on IDC principles is described and comparison with contrast enhanced biplane LV ejection fraction quantification shows accurate results