Benign recurrent intrahepatic cholestasis (BRIC): Evidence of genetic heterogeneity and delimitation of the BRIC locus to a 7-cM interval between D18S69 and D18S64

Benign recurrent intrahepatic cholestasis (BRIC) is an autosomal recessive liver disease characterized by multiple episodes of cholestasis without progression to chronic liver disease. The gene was previously assigned to chromosome 18q21, using a shared segment analysis in three families from the Netherlands. In the present study we report the linkage analysis of an expanded sample of 14 BRIC families, using 15 microsatellite markers from the 18q21 region. Obligate recombinants in two families place the gene in a 7-cM interval, between markers D18S69 and D18S64. All intervening markers had significant LOD scores in two-point linkage analysis. More over, we identified one family in which the BRIC gene seems to be unlinked to the 18q21 region, or that represents incomplete penetrance of the BRIC genotype

Monitoring and evaluation of the environmental dissipation of the marine antifoulant 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in a Danish Harbor

The concentration of marine antifoulant 4,5-dichloro-2-n-octyl-4- isothiazolin-3-one (DCOIT; the active ingredient in Sea-Nin

Chemical and bioscreening in search of toxic chlorine compounds in waste water: Integrative report on the results of the pilot study OVOC

Chemical and bioscreening in search of toxic chlorine compounds in waste water Integrative report on the results of the pilot study OVO

Natuurrealisatie in het programma Ruimte voor de Rivier : Wat zijn de leerpunten van het programma Ruimte voor de Rivier voor combineren vanwater- en natuuropgaven?

In het Ruimte voor de Rivier-programma is ruime ervaring opgedaan in het combineren van hoogwaterveiligheidsopgaven met andere doelen, waaronder natuur. Het is een succesvol programma, dat grotendeels op tijd en binnen budget is uitgevoerd, met veel belangstelling vanuit het buitenland. Dit uitvoeringsprogramma is gebruikt om acht sleutelfactoren te identificeren die van belang zijn bij het realiseren van natuur in uitvoeringsprojecten. De acht sleutelfactoren zijn verdeeld over de categorieën Ambitie, Voldoen aan de wet en Daadkracht. Deze sleutelfactoren bevatten diverse aanbevelingen om natuur in toekomstige water gerelateerde uitvoeringsprojecten mee te nemen. Voor toekomstige uitvoeringsprojecten is het van cruciaal belang om in een vroege fase van een project kansen voor win-winsituaties voor natuur en water in beeld te krijgen. Daarbij is het cruciaal dat in het project de ‘dubbeldoelstelling’ natuurrealisatie en waterveiligheid expliciet benoemd wordt. Gezien de tijdsgeest en de insteek van het Deltaprogramma, dat meer dan het Ruimte voor de Rivierprogramma een sectorale insteek kent, is dit een toekomstige uitdaging

Parent-professional alliance and outcomes of child, parent, and family treatment : A systematic review.

This review systematically explored research examining the relation between parent-professional alliance and outcomes of psychosocial treatments provided to children, and their parents and families. Study findings and methodological characteristics were reviewed to investigate the evidence linking the alliance between parents and professionals to outcomes of child, parent, and family treatment as well as to identify factors that may influence the alliance-outcome association. A systematic review of the literature was conducted that included a search of three electronic databases using specified search terms, followed by a hand search to identify relevant studies. A total of 46 studies (37 published articles and 9 unpublished dissertations) met inclusion criteria. Overall, the findings indicated that higher levels of parent-professional alliance were significantly associated with improved clinical outcomes and stronger treatment engagement. However, some studies found that the parent-professional alliance was not significantly related to clinical outcomes or treatment engagement, and a few studies showed that higher levels of alliance were related to less positive clinical outcomes and lower levels of treatment engagement. Several theoretical (problem type, child age, parent sex) and methodological (source and timing of alliance measurement, alliance-outcome informants, outcome domain, timing of outcome measurement) factors were identified that could influence the alliance-outcome association. Together, our findings emphasize the importance of alliance awareness when working with parents as well as a need for future studies to investigate factors influencing the quality of the parent-professional alliance and alliance-outcome association in child, parent, and family treatment

Predictors of parent-professional alliance in home-based parenting support

A strong parent-professional alliance that increases over the course of care predicts positive outcomes of home-based parenting support. However, little is known about factors that influence the development or maintenance of the alliance in home-based parenting support, limiting professionals ability to optimize the parent-professional alliance and thereby the quality of care. Therefore, the present study examined whether voluntary versus mandated service involvement, previous involvement in similar services, parenting stress, child psychosocial problems, and care expectations were associated with early parent-professional alliance and predicted change in alliance during home-based parenting support services. Questionnaire data from 60 parents (M age?=?40.65?years, SD?=?6.81, range 23–55?years) and their professionals collected early and late in care were analyzed using structural equation modeling. Results indicated that previous involvement in similar services was related to lower levels of early parent-reported alliance, whereas positive care expectations were related to stronger early parent- and professional-reported alliances. Moreover, care expectations predicted change in professional-reported alliance during care, with positive parent expectations predicting a decrease and positive professional expectations predicting an increase in alliance. Voluntary versus mandated service involvement, parenting stress and child psychosocial problems were not found to influence the alliance. These findings emphasize the need for professionals to discuss previous service involvement and care expectations as well as a need for future studies to identify other factors that influence alliance and alliance-building skills