In vitro hip testing in the International Society of Biomechanics coordinate system

Many innovative experiments are designed to answ er research questions about hip biomechanics, however many fail to define a coordinate system. This makes comparisons between studies unreliable and is an unnecessary hurdle in extrapolating experimental results to clinical reality. The aim of this study was to present a specimen mounting protocol which aligns and registers hip specimens in the International Society of Biomechanics (ISB) coordinate system, which is defined by bony landmarks that are identified by palpation of the patient’s body. This wou ld enable direct comparison between experimental testing and clinical gait analysis or radiographic studies. To represent the intact hip, four intact synthetic full - pelves with 8 full - length articulating femora were assembled and digitised to define the IS B coordinate system. Using our proposed protocol, pelvis specimens were bisected into left and right hemi - pelves and femora transected at the mid - shaft, and then mounted in bone pots to represent a typical experimental setup. Anatomical landmarks were re - digitised relative to mechanical features of the bone pots and the misalignment was calculated. The mean misalignment was found to be less than 1.5° flexion/extension, ab/adduction and internal/external rotation for both the pelves and femora; this equate s to less than 2.5 % of a normal range of hip motion. The proposed specimen mounting protocol provides a simple method to align in vitro hip specimens in the ISB coordinate system which enables improved comparison between laboratory testing and clinical s tudies. Engineering drawings are provided to allow others to replicate the simple fixtures used in the protocol

Results of measurements of PM10 at a kerbside location in Breda, the Netherlands

De gemeente Breda heeft geconstateerd dat de meetwaarden van fijn stof (PM10) bij de Tilburgseweg te Breda hoog zijn in vergelijking met de andere meetpunten van het Landelijk Meetnet Luchtkwaliteit (LML) van het RIVM. Dit is zichtbaar in de lijst met geconstateerde overschrijdingsdagen zoals die continu wordt bijgehouden op de website van het LML. Op verzoek van de gemeente Breda heeft de provincie Noord-Brabant de fijnstofconcentraties in de periode van augustus tot en met oktober 2006 gemeten. In de periode augustus tot en met oktober 2006 heeft het RIVM eveneens fijnstofreferentiemetingen verricht. Uit de referentiemetingen volgt dat de metingen van het RIVM en de provincie Noord-Brabant met elkaar in overeenstemming zijn. De meetresultaten van de automatische metingen zijn in overeenstemming met de in Europa geldende kwaliteitscriteria. Uit het equivalentieonderzoek dat in 2006 door het LML heeft plaatsgevonden, volgt dat het aantal gerapporteerde overschrijdingsdagen van het meetstation aan de Tilburgseweg te Breda is aangepast.The Breda local authority has ascertained a higher concentration of particulate matter on the kerbside of the Tilburgseweg (a road running through Breda) than concentrations measured at other locations across the country. These measurements were performed by the Dutch National Air Monitoring Network of the National Institute for Public Health and the Environment (RIVM), which observed the highest concentrations at a kerbside location in the city itself. On the request of the Breda local authorities, the provincial authorities measured the particulate matter concentrations (PM10) from September till October 2006. In the same period, RIVM's Laboratory for Environmental Monitoring performed measurements on particulate matter (PM10) using reference techniques from the European guideline. According to the reference measurements, the measurements done by RIVM (with uncertainties taken into consideration) and the province of Noord-Brabant turned out to be in agreement. The routine measurements performed were shown to satisfy the European quality criteria for PM10 measurement. Finally, judging from the 2006 validation and equivalence study, it was obvious that the reported number of days in which concentrations were exceeded at the kerbside location of the Tilburgseweg in Breda had been adjusted.Gemeente Bred

Additive manufactured push-fit implant fixation with screw-strength pull out

Additive manufacturing offers exciting new possibilities for improving long-term metallic implant fixation in bone through enabling open porous structures for bony ingrowth. The aim of this research was to investigate how the technology could also improve initial fixation, a precursor to successful long-term fixation. A new barbed fixation mechanism, relying on flexible struts was proposed and manufactured as a push-fit peg. The technology was optimized using a synthetic bone model and compared with conventional press-fit peg controls tested over a range of interference fits. Optimum designs, achieving maximum pull-out force, were subsequently tested in a cadaveric femoral condyle model. The barbed fixation surface provided more than double the pull-out force for less than a third of the insertion force compared to the best performing conventional press-fit peg (p < 0.001). Indeed, it provided screw-strength pull out from a push-fit device (1,124 ± 146 N). This step change in implant fixation potential offers new capabilities for low profile, minimally invasive implant design, while providing new options to simplify surgery, allowing for one-piece push-fit components with high levels of initial stability

Reduced tibial strain-shielding with extraosseous total knee arthroplasty revision system

Background Revision total knee arthroplasty (RTKA) has poorer results than primary total knee arthroplasty (TKA), and the prostheses are invasive and cause strain-shielding of the bones near the knee. This paper describes an RTKA system with extracortical fixation. It was hypothesised that this would reduce strain-shielding compared with intramedullary fixation. Methods Twelve replica tibiae were prepared for full-field optical surface strain analysis. They were either left intact, implanted with RTKA components with cemented intramedullary fixation stems, or implanted with a novel design with a tibial tray subframe supported by two extracortical fixation plates and screw fixation. They were loaded to simulate peak walking and stair climbing loads and the surface strains were measured using digital image correlation. The measurements were validated with strain gauge rosettes. Results Compared to the intact bone model, extracortical fixation reduced surface strain-shielding by half versus intramedullary fixation. For all load cases and bone regions examined, the extracortical implant shielded 8–27% of bone strain, whereas the intramedullary component shielded 37–56%. Conclusions The new fixation design, which offers less bone destruction than conventional RTKA, also reduced strain-shielding. Clinically, this design may allow greater rebuilding of bone loss, and should increase long-term fixation

The influence of laser parameters and scanning strategies on the mechanical properties of a stochastic porous material

Additive manufacturing enables architectured porous material design, but 3D-CAD modelling of these materials is prohibitively computationally expensive. This bottleneck can be removed using a line-based representation of porous materials instead, with strut thickness controlled by the supplied laser energy. This study investigated how laser energy and scan strategy affects strut thickness and mechanical strength of porous materials. Specimens were manufactured using varying laser parameters, 3 scan strategies (Contour, Points, Pulsing), 2 porous architectures and 2 materials (Titanium, Stainless Steel), with strut thickness, density, modulus, mechanical strength and build time measured. Struts could be built successfully as low as 15° with a minimum diameter of 0.13 mm. Strut thickness was linearly related to the specific enthalpy delivered by the laser to the melt-pool. For a given stiffness, Titanium specimens built at low power/slow speed had a 10% higher strength than those built at high power/fast speed. The opposite was found in Stainless Steel. As specimen stiffness increased, the Contour Strategy produced samples with the highest strength:stiffness and strength:weight ratio. The Points strategy offered the fastest build time, 20% and 100% faster than the Contour and Pulsing strategies, respectively. This work highlights the importance of optimising build parameters to maximize mechanical performance

The effect of nodal connectivity and strut density within stochastic titanium scaffolds on osteogenesis

Modern orthopaedic implants use lattice structures that act as 3D scaffolds to enhance bone growth into and around implants. Stochastic scaffolds are of particular interest as they mimic the architecture of trabecular bone and can combine isotropic properties and adjustable structure. The existing research mainly concentrates on controlling the mechanical and biological performance of periodic lattices by adjusting pore size and shape. Still, less is known on how we can control the performance of stochastic lattices through their design parameters: nodal connectivity, strut density and strut thickness. To elucidate this, four lattice structures were evaluated with varied strut densities and connectivity, hence different local geometry and mechanical properties: low apparent modulus, high apparent modulus, and two with near-identical modulus. Pre-osteoblast murine cells were seeded on scaffolds and cultured in vitro for 28 days. Cell adhesion, proliferation and differentiation were evaluated. Additionally, the expression levels of key osteogenic biomarkers were used to assess the effect of each design parameter on the quality of newly formed tissue. The main finding was that increasing connectivity increased the rate of osteoblast maturation, tissue formation and mineralisation. In detail, doubling the connectivity, over fixed strut density, increased collagen type-I by 140%, increased osteopontin by 130% and osteocalcin by 110%. This was attributed to the increased number of acute angles formed by the numerous connected struts, which facilitated the organization of cells and accelerated the cell cycle. Overall, increasing connectivity and adjusting strut density is a novel technique to design stochastic structures which combine a broad range of biomimetic properties and rapid ossification

Hanny's Voorwerp: a nuclear starburst in IC2497

We present high and intermediate resolution radio observations of the central region in the spiral galaxy IC 2497, performed using the European VLBI Network (EVN) at 18 cm, and the Multi-Element Radio Linked Interferometer Network (MERLIN) at 18 cm and 6 cm. The e-VLBI observations detect two compact radio sources with brightness temperatures in excess of 105 K, suggesting that they are associated with an AGN located at the centre of the galaxy. We show that IC2497 lies on the FIR-radio correlation and that the dominant component of the 18 cm radio flux density of the galaxy is associated with extended emission confined to sub-kpc scales. IC 2497 therefore appears to be a luminous infrared galaxy that exhibits a nuclear starburst with a total star formation rate (assuming a Salpeter IMF) of ~ 70 M*/yr. Typically, vigorous star forming galaxies like IC2497 always show high levels of extinction towards their nuclear regions. The new results are in-line with the hypothesis that the ionisation nebula "Hanny's Voorwerp", located ~15-25 kpc from the galaxy is part of a massive gas reservoir that is ionised by the radiation cone of an AGN that is otherwise obscured along the observer's line-of- sight.Comment: Paper presented at the 10th EVN Symposium in Manchester, Sep. 201

Endogenous Viral Genes in Thirteen Highly Inbred Chicken Lines and in Lines Selected for Immune Response Traits

Thirteen highly inbred lines of chickens of Leghorn, Spanish, and Egyptian Fayoumi origin, four partly inbred Leghorn lines selected for MHC alleles and immune response to GAT (Ir-GAT), and two replicated, noninbred Leghorn lines divergently selected for multiple immune response traits were subjected to molecular genotyping for endogenous viral (ev) gene sequences. In all highly inbred lines of Leghorn origin, ev 1 alone or both ev 1 and ev 2 were observed. The Spanish and Fayoumi lines had three and five ev genes, respectively, most of which were not readily identifiable with standard Leghorn ev gene loci. The Leghorn lines selected for MHC and Ir-GAT had ev 1 fixed in the population. Differences in ev 3 and ev 5 gene frequency were associated with Ir-GAT in the B1 haplotype, but not in the B19 haplotype. In the noninbred lines, which were divergently selected for multiple traits of immune responsiveness, ev 6 and ev 9 differed in frequency between lines, and both were in lower frequency in the lines selected for high immunoresponsiveness. These two ev genes are the only ones known in White Leghorns that have the gs– chf+ phenotype [expressing chicken helper factor (chf) but not expressing group-specific antigen (gs)]

Use of a Javid™ shunt in the management of axillary artery injury as a complication of fracture of the surgical neck of the humerus: a case report

<p>Abstract</p> <p>Introduction</p> <p>Axillary artery injury is a rare but severe complication of fractures of the surgical neck of the humerus.</p> <p>Case presentation</p> <p>We present a case of axillary artery pseudoaneurysm secondary to such a fracture, in a 82-year-old white woman, presenting 10 weeks after the initial injury, successfully treated with subclavian to brachial reversed vein bypass together with simultaneous open reduction and internal fixation of the fracture. We discuss the use of a Javid™ shunt during combined upper limb revascularisation and open reduction and internal fixation of the fractured humerus.</p> <p>Conclusion</p> <p>This case highlights the usefulness of a Javid™ shunt, over other forms of vascular shunts, in prompt restoration of blood flow to effect limb salvage. It can be considered as a temporary measure whilst awaiting definitive revascularisation which can be performed following fracture fixation.</p