Life at a rural psychiatric hostel : The experience of a group of male residents

The study reported in this thesis describes and analyses the experience of 15 men with long term mental illness, living and/or working at a rural farm and hostel complex. The research was set in the context of recent studies and literature focussing on the transfer of care of people with mental illness from large psychiatric hospitals to community based care and the consequent quality of life issues. A phenomenological approach was chosen as the most appropriate for the study, in order to understand the meaning of the residents\u27 experience. Data was obtained from three sources: in-depth interviews with 2 key informants, 50 hours participant observation involving 15 residents and 8 staff and focussed or semi-structured interviews with 10 participants. The Ethnograph computer program was utilised to facilitate and expedite analysis of the resulting large volume of data

Strategic momentum: the immediate outcome of an effective strategy formation process

strategy

Mitochondrial and chloroplast stress responses are modulated in distinct touch and chemical inhibition phases

Previous studies have identified a range of transcription factors that modulate retrograde regulation of mitochondrial and chloroplast functions in Arabidopsis (Arabidopsis thaliana). However, the relative importance of these regulators and whether they act downstream of separate or overlapping signaling cascades is still unclear. Here, we demonstrate that multiple stress-related signaling pathways, with distinct kinetic signatures, converge on overlapping gene sets involved in energy organelle function. The transcription factor ANAC017 is almost solely responsible for transcript induction of marker genes around 3 to 6 h after chemical inhibition of organelle function and is a key regulator of mitochondrial and specific types of chloroplast retrograde signaling. However, an independent and highly transient gene expression phase, initiated within 10 to 30 min after treatment, also targets energy organelle functions, and is related to touch and wounding responses. Metabolite analysis demonstrates that this early response is concurrent with rapid changes in tricarboxylic acid cycle intermediates and large changes in transcript abundance of genes encoding mitochondrial dicarboxylate carrier proteins. It was further demonstrated that transcription factors AtWRKY15 and AtWRKY40 have repressive regulatory roles in this touch-responsive gene expression. Together, our results show that several regulatory systems can independently affect energy organelle function in response to stress, providing different means to exert operational control

Observations of fronts in the North Sea

The persistent presence of a cold bottom layer and associated bottom fronts was observed in the stratified central North Sea during an observational program in 1981 and 1982. Moored instruments, capturing a snap-shot of such a front while it was advected past these moorings, revealed the simultaneous presence of a well-defined frontal jet with velocities up to 15 cm s−1. The Coriolis force acting on this jet appeared to be in geostrophic balance with the locally intense pressure gradient forces. Hydrographic surveys revealed the presence of both small-scale and large-scale baroclinic waves on this front, the latter reaching wavelengths of 5–10 internal Ross by radii. Some evidence for a weak secondary circulation in the cross-frontal plane was obtained from the observed deformation of isolines near the front

Digital modulation of the nickel valence state in a cuprate-nickelate heterostructure

Layer-by-layer oxide molecular beam epitaxy has been used to synthesize cuprate-nickelate multilayer structures of composition (La$_2$CuO$_4$)$_m$/LaO/(LaNiO$_3$)$_n$. In a combined experimental and theoretical study, we show that these structures allow a clean separation of dopant and doped layers. Specifically, the LaO layer separating cuprate and nickelate blocks provides an additional charge that, according to density functional theory calculations, is predominantly accommodated in the interfacial nickelate layers. This is reflected in an elongation of bond distances and changes in valence state, as observed by scanning transmission electron microscopy and x-ray absorption spectroscopy. Moreover, the predicted charge disproportionation in the nickelate interface layers leads to a thickness-dependent metal-to-insulator transition for $n=2$, as observed in electrical transport measurements. The results exemplify the perspectives of charge transfer in metal-oxide multilayers to induce doping without introducing chemical and structural disorder