A single-center non-blinded randomized clinical trial to assess the safety and effectiveness of PhR160 spray in the treatment of COVID-19 pneumonia

7-16COVID-19 is an emerging pandemic that caused a very widespread infection with more than 1000000 cases in Iran within a year. The main cause of mortality among patients with COVID-19 is pulmonary failure. In Iranian Traditional Medicine, essences have been used for curing pulmonary diseases. Pinen-Hydronoplacton-Ribonucleic acid (PHR) is an inhaler spray made of seven different plants, which all are used by humans and have desirable pharmacological features for treating pulmonary symptoms of COVID-19 patients. This study was conducted to assess the safety and effectiveness of PHR160 spray in improving pulmonary symptoms of COVID-19 patients. This was a single-centre, non-blinded randomized clinical trial with two parallel groups in two different wards of Baqiyatallah hospital, Tehran, Iran. Participants were 63 male patients diagnosed with COVID-19 pneumonia, divided into 2 groups of 32 in the intervention group and 31 in the control group. The intervention group received 5 days of PHR160 spray, 10 puffs each day, 300 micrograms in each puff in addition to the routine treatment. Oxygen saturation was measured by a pulse oximeter, every six hours and recorded daily. This study showed that administration of PhR 160 in patients of COVID-19 was safe, and it significantly increased the arterial oxygen saturation percentage in COVID-19 patients. In addition, it decreased hospitalization duration, dyspnea score, and cough score significantly in the patients. The statistical modelling test, with adjusting the age and respiratory rate for baseline and 4 days of the intervention, shows that the oxygen saturation percentage mean was significantly more in the intervention group by 5.14 units (p<0.001)

It is possible for people diagnosed with schizophrenia to recover

Services that support individuals with a diagnosis of Serious Mental Illness are called upon to deliver services that seek to promote their recovery.The National Institute for Mental Health in England (NIMHE, 2005), have been working towards defining the key features of what a recovery oriented service should look like. Optimistic as it may seem, services are a long way to undoing the effects of institutionalisation in the lives of many service users. This article provides an account of an evaluation of a Recovery Group designed to introduce participants to the recovery paradigm, in an attempt to help enhance their hopefulness about their future. It was hypothesised that when people are hopeful about achieving their goals, then they will become more motivated to pursue meaningful activities. An eight week group was conducted using outcome measures such as the Beck Hopelessness scale (1974), Lancashire Quality of Life scale, Bradburn Affect Scale and Cantill’s Life Ladder. Seven mental health service users from a Rehabilitation Inpatient Unit, and Community Team participated in the Recovery group, of whom four service users completed the programme. Despite methodological limitations of this evaluation some improvements were noted for the service users in terms of improved quality of life, a sense of optimism for the future and improved psychological well-being