Improved Method for the Obtaining DTTA-appended 2,2’-bipyridine Ligands for Lanthanide Cations

Received: 25.03.22. Revised: 24.05.22. Accepted: 24.05.22. Available online: 30.05.22.The composition of the reaction mixture after DTTA tert-butyl ester alkylation with 6'-halomethyl-5-phenyl-2,2'-bipyridines was studied. In addition to the target product, DTTA-appended 2,2’-bipyridine, the corresponding 6'-hydroxymethyl-substituted 2,2’-bipyridine and (5'-phenyl-[2,2'-bipyridin]-6-yl)methyl formate were isolated as byproducts in some cases. Finally, an improved procedure for the DTTA tert-butyl ester alkylation with 6'-halomethyl-5-phenyl-2,2'-bipyridines by using Finkelstein reaction was developed.This work was supported by the Russian Science Foundation (grant no. 18-73-10119-P)