Soluble Insulin Receptor Levels (MFI) and HIV-seropositive women stratified by HAND.

a<p>MFI  =  Median Fluorescence Intensity; median (interquartile range [25^th and 75^th percentile]),</p>b<p>significant p value<0.05^*.</p

Soluble insulin receptor full-length (sIRαβ) stratified by HAND.

<p>Soluble insulin receptor (sIR) intact or full-length (αβ) subunit was measured by ELISA <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037358#pone.0037358-The1" target="_blank">[47]</a> in plasma (A) and CSF (B) of HIV-seropositive women (HIV+) (n = 34) stratified by HAND into normal cognition (n = 11), asymptomatic impairment (n = 8), and symptomatic impairment (n = 15); and 10 HIV-negative controls (HIV−) (5 plasma were different women from 5 CSF). In plasma (A), levels of full-length sIR were significantly increased from controls in all HIV-seropositive women and it correlated with the severity of HAND (normal cognition [p = 0.003], asymptomatic impairment [p<0.001], and symptomatic impairment [p<0.001]). Also, women with symptomatic impairment had significant higher levels of full-length sIR when compared to those with normal cognition (p = 0.009). A similar trend was observed in CSF samples (B), although the only significant increased was observed in the women with symptomatic impairment when compared to controls. (MFI = Median Fluorescence Intensity).</p

Membrane insulin receptor (mIR), insulin receptor substrate 1 (IRS-1), and IRS-1 tyrosine phosphorylation levels in the CSF white cell pellet (CSF WCP) stratified by HAND.

a<p>For the mIR (MFI) and IRS-1 we analyzed 11 women with normal cognition, 8 with asymptomatic impairment, and 15 with symptomatic impairment. For IRS-1 tyrosine phosphorylation 5 women per group were analyzed;</p>b<p>significant p value<0.05^*;</p>c<p>MFI = Median Fluorescence Intensity; median (interquartile range [25^th and 75^th percentile]).</p

Soluble insulin receptor full-length (sIRαβ) and HIV.

<p>Soluble insulin receptor (sIR) intact or full-length (αβ) was measured in plasma (A) and CSF (B) of HIV-seropositive women (HIV+) (n = 34) and controls (HIV−) (n = 10, 5 with plasma and different 5 for CSF). The sIR subunits were determined using an ELISA <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037358#pone.0037358-The1" target="_blank">[47]</a> Significantly higher levels of full-length sIR was observed in HIV-seropositive women in plasma and CSF when compared with controls (p<0.001 and p = 0.003 respectively). (MFI = Median Fluorescence Intensity).</p

Insulin Receptor Substrate 1 (IRS-1) tyrosine phosphorylation stratified by HAND.

<p>Insulin receptor substrate 1 (IRS-1) tyrosine phosphorylation was determined in CSF cell pellets of 23 HIV-seropositive women (HIV+) stratified by HAND (7 with normal cognition, 7 with asymptomatic impairment, and 9 with symptomatic impairment) using flow cytometry. A significant decrease in IRS-1 tyrosine phosphorylation was observed between HIV-seropositive women with normal cognition and symptomatic impairment (p = 0.02). (MFI = Median Fluorescence Intensity).</p

Health-Related Resiliency Scale in English.

<p>INSTRUCTIONS: Read each phrase carefully. Circle the answer that best indicates the way you thought and felt (never, rarely, sometimes, frequently, always) about each one in the previous 7 days. Remember that there are no right or wrong answers.</p

Content validity indices.

<p>Content validity indices.</p

Reliability and descriptive statistics.

<p>Reliability and descriptive statistics.</p

Health-Related Resiliency Scale in Spanish.

<p>INSTRUCCIONES: Lee cada frase cuidadosamente. Circula la respuesta que mejor indique la forma en la que has pensado y te has sentido (Nunca, Casi nunca, Raras veces, A veces, Siempre) durante los últimos 7 días. Recuerda que no hay respuestas correctas ni incorrectas.</p

Predicted network of interactions between the proteins identified in macrophages from HACI patients.

<p>(A) Blue proteins are from our dataset and the grey colored proteins are the ones that connect the proteins in our dataset according to IPA software. (B) The lower panel shows the pattern of increase/decrease followed by vimentin, EEF1 and cathepsin B among the groups of HACI patients.</p