11 research outputs found
Dynamic Topographical Control of Mesenchymal Stem Cells by Culture on Responsive Poly(ϵ-caprolactone) Surfaces
Photoresponsive Polyesters for Tailorable Shape Memory Biomaterials
The
synthesis of a library of poly(ester urethane)s (PEUs) containing
pendant photoresponsive moieties afforded through the incorporation
of one of two novel bifunctional monomers resulted in degradable materials
with a range of tunable thermal and mechanical properties. Utilizing
light irradiation, macroscopic temporary shapes were fixed by increasing
the cross-link density of a thermoset network via photoinduced reversible
[2 + 2] cycloaddition of cinnamamide or cinnamate pendant groups under
UV light (λ = 302 nm). Further irradiation with UV light (λ
= 254 nm) led to the cleaving of the temporary cross-links and recovery
of the original shape. Examination of these materials under physiological
conditions displayed tunable degradation with rates faster than PCL-based
materials, and initial biocompatibility studies exhibited negligible
cytotoxicity for HeLa cells based on results of ATP assay. The ability
to tune thermal properties also allowed specific polymer compositions
to boast transition temperatures within a range of applicable temperature
for thermal shape memory
It Is the Outside That Counts: Chemical and Physical Control of Dynamic Surfaces
Materials capable of dynamically controlling surface
chemistry
and topography are highly desirable. We have designed a system that
is uniquely able to remotely control the presented functionality and
geometry at a given time by using a functionalizable shape memory
material. This was accomplished by incorporating controlled amounts
of an azide-containing monomer into a shape memory polymeric material.
These materials are capable of physically changing surface geometry
over a broad range of length scales from >1 mm to 100 nm. Using
copper-assisted
click chemistry, they can be functionalized with a variety of molecules
to yield different surfaces. Combining these features gave materials
that can change both the presented geometry and functionality at tunable
transition temperatures
It Is the Outside That Counts: Chemical and Physical Control of Dynamic Surfaces
Materials capable of dynamically controlling surface
chemistry
and topography are highly desirable. We have designed a system that
is uniquely able to remotely control the presented functionality and
geometry at a given time by using a functionalizable shape memory
material. This was accomplished by incorporating controlled amounts
of an azide-containing monomer into a shape memory polymeric material.
These materials are capable of physically changing surface geometry
over a broad range of length scales from >1 mm to 100 nm. Using
copper-assisted
click chemistry, they can be functionalized with a variety of molecules
to yield different surfaces. Combining these features gave materials
that can change both the presented geometry and functionality at tunable
transition temperatures
Grafting Poly(OEGMA) Brushes from a Shape Memory Elastomer and Subsequent Wrinkling Behavior
An
azide-functionalized shape memory elastomer, poly(octylene diazoadipate-<i>co</i>-octylene adipate), has been grafted with poly(oligoethylene
glycol) methacrylate (poly(OEGMA)) brushes via aqueous ARGET (activators
regenerated by electron transfer) ATRP. Sequential swelling of the
substrate followed by a grafting-from reaction yielded an incompressible
brush layer on the shape-memory substrate. Upon heating the substrate
above the <i>T</i><sub>m</sub> to return to the primary
shape, uniaxial wrinkles perpendicular to the direction of strain
with sizes of 27–33 μm appear in addition to micrometer-sized
features formed on the temporary shape after grafting. Swelling equilibration
time (<i>t</i><sub>1</sub>) and grafting reaction time (<i>t</i><sub>2</sub>) were varied to control wrinkle formation
and size. In this manner, we were able to create unique, anisotropic
hierarchical surface structures with different length scales and patterns
Switchable Micropatterned Surface Topographies Mediated by Reversible Shape Memory
Reversibly switching topography on
micrometer length scales greatly expands the functionality of stimuli-responsive
substrates. Here we report the first usage of reversible shape memory
for the actuation of two-way transitions between microscopically patterned
substrates, resulting in corresponding modulations of the wetting
properties. Reversible switching of the surface topography is achieved
through partial melting and recrystallization of a semi-crystalline
polyester embossed with microscopic features. This behavior is monitored
with atomic force microscopy (AFM) and contact angle measurements.
We demonstrate that the magnitude of the contact angle variations
depends on the embossment pattern
Dynamic Optical Gratings Accessed by Reversible Shape Memory
Shape memory polymers (SMPs) have
been shown to accurately replicate photonic structures that produce
tunable optical responses, but in practice, these responses are limited
by the irreversibility of conventional shape memory processes. Here,
we report the intensity modulation of a diffraction grating utilizing
two-way reversible shape changes. Reversible shifting of the grating
height was accomplished through partial melting and recrystallization
of semicrystalline poly(octylene adipate). The concurrent variations
of the grating shape and diffraction intensity were monitored via
atomic force microscopy and first order diffraction measurements,
respectively. A maximum reversibility of the diffraction intensity
of 36% was repeatable over multiple cycles. To that end, the reversible
shape memory process is shown to broaden the functionality of SMP-based
optical devices