Prognostic Significance of Anthropometric and Bioimpedance Parameters of Yakut Women for Birth of Newborns with High Body Weight

The aim of this study was to identify the prognostically significant anthropometric and bioimpedance indicators for the birth of a child with a high body weight in Yakut women. The study included 220 women of Yakut nationality with physiological pregnancy and childbirth who were examined on the third and fourth days after delivery. The parameters of anthropometry and bioimpedancemetry in parturient women and the anthropometric indices of newborns were investigated. Anthropometric measurements were carried out according to the method of V.V. Bunak. Body composition was assessed based on bioimpedance analysis using the ABC-01 MEDASS device (Medass, Russia). The conducted research revealed that the anthropometric and bioimpedance indices of Yakut women in the postpartum period (3-4 days after delivery) were significantly different from general population indicators. The parameters of body weight and body mass index of the puerperal women were significantly higher, and phase angle and Xc50 - significantly lower. Principal component analysis revealed anthropometric and bioimpedance indices predicting a high birth weight. The obtained data in combination with other indicators can be used to predict the birth of a child with a high birth weight in Yakut women

Associations Between Neuropsychophysiological and Dermatoglyphic Indicators in the Assessment of Human Health

The purpose of this study was to explore the relationship between psycho-physiological markers of human health and dermatoglyphic indicators in young people. Materials and Methods: The study included 920 healthy volunteers aged between 18 and 21 years. All volunteers underwent the following examinations: EEG, an assessment of the anxiety level according to the BAI, and dermatoglyphic scanning. Results: According to the data obtained, there was a statistically significant strong negative correlation between the stress load indicator and dermatoglyphic data, such as the summary delta index (DI) and summary ridge count. A strong positive correlation was found between the percentage of whorls and stress (r=0.88). The predominant increase in anxiety is characteristic of persons with total ridge count (TRC) on the thumb of the right hand in the range from 19 to 23. Conclusion: Results demonstrate the interrelationships (association) between psycho-physiological (anxiety level, stress load indicator) and dermatoglyphic markers (DI, TRC and whorl pattern type) in young healthy people

A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand

The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the known mutational signatures of the nuclear genome and variation in mtDNA mutational spectra between different organisms is still incomprehensible. Since mitochondria are responsible for aerobic respiration, it is expected that mtDNA mutational spectrum is affected by oxidative damage. Assuming that oxidative damage increases with age, we analyse mtDNA mutagenesis of different species in regards to their generation length. Analysing, (i) dozens of thousands of somatic mtDNA mutations in samples of different ages (ii) 70053 polymorphic synonymous mtDNA substitutions reconstructed in 424 mammalian species with different generation lengths and (iii) synonymous nucleotide content of 650 complete mitochondrial genomes of mammalian species we observed that the frequency of A(H) > G(H) substitutions (H: heavy strand notation) is twice bigger in species with high versus low generation length making their mtDNA more A(H) poor and G(H) rich. Considering that A(H) > G(H) substitutions are also sensitive to the time spent single-stranded (TSSS) during asynchronous mtDNA replication we demonstrated that A(H) > G(H) substitution rate is a function of both species-specific generation length and position-specific TSSS. We propose that A(H) > G(H) is a mitochondria-specific signature of oxidative damage associated with both aging and TSSS