ARDD 2020: from aging mechanisms to interventions

Aging is emerging as a druggable target with growing interest from academia, industry and investors. New technologies such as artificial intelligence and advanced screening techniques, as well as a strong influence from the industry sector may lead to novel discoveries to treat age-related diseases. The present review summarizes presentations from the 7th Annual Aging Research and Drug Discovery (ARDD) meeting, held online on the 1st to 4th of September 2020. The meeting covered topics related to new methodologies to study aging, knowledge about basic mechanisms of longevity, latest interventional strategies to target the aging process as well as discussions about the impact of aging research on society and economy. More than 2000 participants and 65 speakers joined the meeting and we already look forward to an even larger meeting next year. Please mark your calendars for the 8th ARDD meeting that is scheduled for the 31st of August to 3rd of September, 2021, at Columbia University, USA

Temperature affects longevity and age-related locomotor and cognitive decay in the short-lived fish Nothobranchius furzeri

Temperature variations are known to modulate aging and life-history traits in poikilotherms as different as worms, flies and fish. In invertebrates, temperature affects lifespan by modulating the slope of age-dependent acceleration in death rate, which is thought to reflect the rate of age-related damage accumulation. Here, we studied the effects of temperature on aging kinetics, aging-related behavioural deficits, and age-associated histological markers of senescence in the short-lived fish Nothobranchius furzeri. This species shows a maximum captive lifespan of only 3 months, which is tied with acceleration in growth and expression of aging biomarkers. These biological peculiarities make it a very convenient animal model for testing the effects of experimental manipulations on life-history traits in vertebrates. Here, we show that (i) lowering temperature from 25 degrees C to 22 degrees C increases both median and maximum lifespan; (ii) life extension is due to reduction in the slope of the age-dependent acceleration in death rate; (iii) lowering temperature from 25 degrees C to 22 degrees C retards the onset of age-related locomotor and learning deficits; and (iv) lowering temperature from 25 degrees C to 22 degrees C reduces the accumulation of the age-related marker lipofuscin. We conclude that lowering water temperature is a simple experimental manipulation which retards the rate of age-related damage accumulation in this short-lived species

A Benchmark for Geometric Facial Beauty Study

2nd International Conference on Medical Biometrics, ICMB 2010, Hong Kong, 28-30 June 2010This paper presents statistical analyses for facial beauty study. A large-scale database was built, containing 23412 frontal face images, 875 of them are marked as beautiful. We focus on the geometric feature defined by a set of landmarks on faces. A normalization approach is proposed to filter out the non-shape variations - translation, rotation, and scale. The normalized features are then mapped to its tangent space, in which we conduct statistical analyses: Hotelling's T2 test is applied for testing whether female and male mean faces have significant difference; Principal Component Analysis (PCA) is applied to summarize the main modes of shape variation and do dimension reduction; A criterion based on the Kullback-Leibler (KL) divergence is proposed to evaluate different hypotheses and models. The KL divergence measures the distribution difference between the beautiful group and the whole population. The results show that male and female faces come from different Gaussian distributions, but the two distributions overlap each other severely. By measuring the KL divergence, it shows that multivariate Gaussian model embodies much more beauty related information than the averageness hypothesis and the symmetry hypothesis. We hope the large-scale database and the proposed evaluation methods can serve as a benchmark for further studies.Department of Computin