Alternative Sentencing & Strategies for Successful Prisoner Reentry

Nationally, more than two million people are serving time in prison on any given day. Missouri ranks eighth in the nation in terms of imprisonment and has experienced substantial growth in incarceration over the past two decades. The reality of mass incarceration and the accruing cost of corrections have led many states to consider implementing alternatives to traditional incarceration and parole. These alternatives between parole and confinement are often called intermediate sanctions and are intended to provide correctional options that save money and prison beds without introducing risk to public safety. The State of Missouri has made strides in developing sanctions that can serve as an alternative to prison. Section 217.777.1, RSMo, charges the Missouri Department of Corrections with the administration of a community corrections program to encourage the establishment of local sentencing initiatives and correctional alternatives. Among the goals of this legislation and alternative sanctions in general, are to: Promote the accountability of offenders to crime victims, local communities and the state; Increase the use of restitution; Reduce the costs of treatment, punishment and supervision of off enders; and Improve public confidence in the criminal justice system by involving the public in the development of community-based sentencing options for eligible offenders.Includes bibliographical reference

Cost-Effectiveness of Early versus Late Cinacalcet Treatment in Addition to Standard Care for Secondary Renal Hyperparathyroidism in the USA

AbstractObjectivesThe objective of this research was to estimate lifetime cost-effectiveness of treating patients with cinacalcet early (when parathyroid hormone [PTH] levels are in the range of 300–500 pg/ml) versus delaying treatment with cinacalcet (cinacalcet initiated when PTH levels are >800 pg/ml) in patients with secondary hyperparathyroidism (SHPT) in the US setting.MethodsA Markov model was developed to simulate the effects of early versus delayed use of cinacalcet (plus standard of care). Four different PTH ranges (≤300 pg/ml; 301–500 pg/ml; 501–800 pg/ml; >800 pg/ml) were used to represent four different health states within the Markov model. Associated with each Markov state (PTH range) were varying risks of major SHPT complications, including cardiovascular disease (CVD), fracture (Fx), and parathyroidectomy (PTx). Baseline cohort characteristics and risks of CVD, Fx, and PTx by PTH category were derived from a large US renal database and published sources. Costs were estimated from the US Renal Data System database and reported in 2006 US Dollars ($). Clinical and economic outcomes were discounted at 3.0$17,275 per QALY gained.ConclusionsEarly treatment with cinacalcet was associated with improvements in QALYs and would represent good value for money compared to delaying treatment with cinacalcet

A retrospective study of brain lesions in goats submitted to three veterinary diagnostic laboratories

A retrospective study of brain lesions in goats was conducted to identify the range of lesions and diseases recognized and to make recommendations regarding the best tissues to examine and tests to conduct in order to maximize the likelihood of making a definitive diagnosis in goats that may have had clinical signs referable to the brain. One hundred thirty-nine goats with a brain lesion were identified. The most common lesion, in 52.5% of the goats, was suppurative inflammation. Approximately two-thirds of these goats had encephalitic listeriosis. Other goats were found to have suppurative inflammation in association with septicemia, pituitary abscesses, dehorning injury, and otitis. Thirty goats (21.6%) were diagnosed with polioencephalomalacia. Twenty-one goats (15.1%) were diagnosed with nonsuppurative inflammation. In more than half of these goats, no definitive diagnosis was made, while 8 were infected with Caprine arthritis encephalitis virus and 1 with Rabies virus. However, few goats were tested for rabies. Based on these findings, it is recommended that, in addition to appropriate handling of the brain, the head should be examined with attention paid to the sella turcica and the temporal bones for evidence of a pituitary abscess and otitis, respectively. Histologic examination should include multiple areas of the brain, including the brainstem, for lesions of encephalic listeriosis; the cerebral cortex, for lesions of polioencephalomalacia; and the hippocampus, for Negri bodies associated with Rabies virus infection. Consideration should be given to collecting samples of other tissues including, but not limited to, the spinal cord and liver for ancillary testing if warranted.Keywords: Goats, Brain lesionsKeywords: Goats, Brain lesion

Erythrocytosis and fatigue fractures associated with hepatoblastoma in a 3-year-old gelding

Hepatoblastoma was diagnosed in a 3-year-old Thoroughbred gelding presented with forelimb lameness with bilateral fatigue fractures of the proximal third metacarpal bones. An abdominal mass was detected on ultrasound examination of the abdomen. Absolute erythrocytosis was diagnosed after clinical and haematological evaluation. The fractured metacarpal bones were surgically removed but complications after surgery were fatal. The liver mass was diagnosed as a hepatoblastoma based on histology and immunochemical staining. The combination of hepatoblastoma and fatigue fractures has not been described previously in horses. A potential link between the hepatic and orthopaedic pathologies is hypothesised

Distinctive tumour of the tongue in 3 horses

Tumours arising from the dorsal surface of the tongue occurred in 3 horses from 14-23 years of age. Tumours were surgically excised at a referral hospital (1 case) and on the farm (2 cases) and submitted for histopathology. All tumours were multilobular and composed of vaguely nested, bland, oval to slightly elongate cells with an infiltrative growth pattern. Mitotic activity was not detected. Immunohistochemical studies found that tumour cells were often positive for S-100 and cytokeratin and were occasionally positive for vimentin. Tumour cells were negative for glial fibrillary acidic protein, neuron specific enolase, synaptophysin, muscle actin, and chromogranin A. Follow up obtained from 7 months to 2 years following tumour removal indicated no evidence of regrowth or metastasis. The origin of these distinctive tumours is not clear, but the immunohistochemical profile suggests the possibility of origin from lingual taste buds. These cases and review of the literature indicate that successful surgical excision of tongue tumours can be performed by practitioners in private practice as well as by surgeons at referral hospitals.Keywords: immunohistochemistry, tongue, horse, neoplasi

Expression of serotonin, chromogranin-A, serotonin receptor-2B, tryptophan hydroxylase-1, and serotonin reuptake transporter in the intestine of dogs with chronic enteropathy

Serotonin regulates many intestinal motor and sensory functions. Altered serotonergic metabolism has been described in human gastrointestinal diseases. The objective of our study was to compare expression of several components of the serotonergic system [serotonin (5-HT), serotonin reuptake transporter protein (SERT), tryptophan hydroxylase-1 (TPH-1), 5-HT receptor[subscript 2B] (5-HT[subscript 2B])] and the enterochromaffin cell marker chromogranin-A (CgA) in the intestinal mucosa between dogs with chronic enteropathy and healthy controls. Serotonin and CgA expression were determined by immunohistochemistry using banked and prospectively obtained, paraffin-embedded canine gastrointestinal biopsies (n = 11), and compared to a control group of canine small intestinal sections (n = 10). Expression of SERT, TPH-1, and 5-HT[subscript 2B] were determined via real-time reverse transcription polymerase chain reaction (qRT-PCR) using prospectively collected endoscopic duodenal biopsies (n = 10) and compared to an additional control group of control duodenal biopsies (n = 8, Control Group 2) showing no evidence of intestinal inflammation. Dogs with chronic enteropathies showed strong staining for both 5-HT and CgA. Mean positive cells per high power field (HPF) were significantly increased for both compounds in dogs with chronic enteropathies (p < 0.001 for 5-HT and p < 0.05 CgA). The number of 5-HT–positive and CgA-positive cells/HPF showed significant correlation in the entire group of dogs, including both diseased and healthy individuals (Pearson r² = 0.2433, p = 0.016). No significant differences were observed for SERT, TPH-1, or 5-HT[subscript 2B] expression; however, dogs with chronic enteropathy showed greater variability in expression of TPH-1 and 5-HT[subscript 2B]. We conclude that components of the neuroendocrine system show altered expression in the intestinal mucosa of dogs with chronic enteropathy. These changes may contribute to nociception and clinical signs in these patients.Keywords: Chronic enteropathy, Inflammatory bowel disease, Enterochromaffin cells, Dogs, Immunohistochemistry, NeuroendocrineKeywords: Chronic enteropathy, Inflammatory bowel disease, Enterochromaffin cells, Dogs, Immunohistochemistry, Neuroendocrin

Alopecia areata in two black Angus cows

Adult onset progressive alopecia and leukotrichia developed in 2 registered black Angus cows, aged 6 and 7 years. Histopathologic findings in skin were prominent melanin clumping and degeneration of matrix cells with formation of giant multinucleate cells within hair bulbs, accompanied by peribulbar melanin incontinence and fibrosis and dystrophic hair shafts. Intrabulbar and peribulbar lymphocytes were cluster of differentiation (CD)3-positive T cells. Findings were characteristic of alopecia areata.Keywords: Alopecia areata, Dermatosis, Cattle, Immunohistochemistr

Fatal Caprine arthritis encephalitis virus– like infection in 4 Rocky Mountain goats (Oreamnos americanus)

Over a 3.5-year period, 4 Rocky Mountain goats (Oreamnos americanus), housed at a single facility, developed clinical disease attributed to infection by Caprine arthritis encephalitis virus (CAEV). Ages ranged from 1 to 10 years. Three of the goats, a 1-year-old female, a 2-year-old male, and a 5-year-old male, had been fed raw domestic goat milk from a single source that was later found to have CAEV on the premises. The fourth animal, a 10-year-old male, had not ingested domestic goat milk but had been housed with the other 3 Rocky Mountain goats. All 4 animals had clinical signs of pneumonia prior to death. At necropsy, findings in lungs included marked diffuse interstitial pneumonia characterized histologically by severe lymphoplasmacytic infiltrates with massive alveolar proteinosis, interstitial fibrosis, and type II pneumocyte hyperplasia. One animal also developed left-sided hemiparesis, and locally extensive lymphoplasmacytic myeloencephalitis was present in the cranial cervical spinal cord. Two animals had joint effusions, as well as severe lymphoplasmacytic and ulcerative synovitis. Immunohistochemical staining of fixed sections of lung tissue from all 4 goats, as well as spinal cord in 1 affected animal, and synovium from 2 affected animals were positive for CAEV antigen. Serology testing for anti-CAEV antibodies was positive in the 2 goats tested. The cases suggest that Rocky Mountain goats are susceptible to naturally occurring CAEV infection, that CAEV from domestic goats can be transmitted to this species through infected milk and by horizontal transmission, and that viral infection can result in clinically severe multisystemic disease.Keywords: Viral disease, Rocky Mountain goats, Myelitis, Interstitial pneumonia, Goats, Arthritis, Caprine arthritis encephalitis viru

Post-traumatic ocular lymphoma in three rabbits (Oryctolagus cuniculus)

This report describes post-traumatic ocular lymphoma in 3 companion rabbits; 2 rabbits with unilateral disease and 1 with bilateral disease. Historical findings suggestive of a traumatic event included either external unilateral ocular trauma or bilateral phacoemulsification. Severe corneal changes, presence of an anterior chamber mass(es), low intraocular pressures, and ocular discomfort were noted on ophthalmic examinations. All eyes were treated for variable courses with standard ophthalmic topical medications (antibiotic, anti-inflammatories, and steroid) and systemic anti-inflammatories. Based upon progression of disease, all affected eyes were ultimately enucleated; lenticular capsular rupture and a round cell neoplasm effacing normal structures with variable mitotic indices were noted on histopathology. Neoplastic lymphocytes strongly expressed CD79a via immunohistochemistry and lacked expression for CD3, indicating B lymphocyte lineage and not of T cell lineage. A single animal had evidence of local metastasis to a regional lymph node. Post-traumatic sarcomas have been reported in this species previously, however, these cases are the first reports of this novel round cell variant, named post-traumatic ocular lymphoma due to the B cell lineage confirmed through immunohistochemistry. Clinicians should be aware of this clinical presentation and the possibility of metastasis when evaluating ocular pathology in this species. Copyright 2018 Elsevier Inc. All rights reserved