Diagnostic Clue in a Neonate with Amniotic Band Sequence

Amniotic band syndrome (ABS) is a set of congenital malformations that mainly affect the limbs and more rarely the skull, face, chest, and abdomen. Two main hypotheses have been proposed to explain the nature of the disorder: an intrinsic and extrinsic factor. We report a newborn with ABS presenting with several malformations involving both hands and foot. In this case, the malformative event localized at the hands and right foot without involvement of any other internal organs and is asymmetric which leads us to suppose the extrinsic factor as cause of the ABS

Promotion of Fruits and Vegetables Consumption: Results of a School-Based Intervention in a Sample of 13-15 Years Old Italian Students

Background: The …e vai con la frutta (let’s go with fruit) project was designed to respond to the worrying low consumption of fruits and vegetable in the large portion of population, especially in youth. The main objective was to increase fruit and vegetable consumptions at school level. Methods: In 2010/11, we randomly selected subjects from middle and high schools in five Italian regions. The subjects were randomly divided into two groups: intervention (I) and control (C). A questionnaire on fruits and vegetables consumption was administered, at the baseline as well as at end of the period. The sample size was evaluated on the expected frequency of 0.5 for a binomial random variable, of ± 1.54% with IC of 95%. Results: These results confirmed that adolescent students at baseline survey eat less than the amount of fruits and vegetables consumption recommended by the International guidelines. After the intervention time, we observed an increment in fruits and vegetables consumptions both in middle and high school students. Regarding the impact of the intervention on the factors like knowledge, attitudes and behaviour, there was a positive change in the behaviour only in the intervention group, in coherence with the consumption variations examined. Conclusions: This study is the first time that fruits and vegetables were offered at such a large scale through vending machines at schools in five regions. Several vending companies under this project agreed to revise the list of healthy snacks offered to eliminate those clearly classified as junk foods

Monogenic Syndromes with Congenital Heart Diseases in Newborns (Diagnostic Clues for Neonatologists): A Critical Analysis with Systematic Literature Review

Congenital heart disease (CHD), the most common major congenital anomaly, is associated with a genetic syndrome (chromosomal anomalies, genomic disorders, or monogenic disease) in 30% of patients. The aim of this systematic review was to evaluate if, in the neonatal setting, clinical clues that orient the diagnostic path can be identified. For this purpose, we revised the most frequent dysmorphic features described in newborns with CHD, comparing those associated with monogenic syndromes (MSG) with the ones reported in newborns with genomic disorders. For this systematic review according to PRISMA statement, we used PubMed, Medline, Google Scholar, Scopus database, and search terms related to CHD and syndrome. We found a wide range of dysmorphisms (ocular region, ears, mouth, and/or palate and phalangeal anomalies) detected in more than half of MSGs were found to be associated with CHDs, but those anomalies are also described in genomic rearrangements syndromes with equal prevalence. These findings confirmed that etiological diagnosis in newborns is challenging, and only the prompt and expert recognition of features suggestive of genetic conditions can improve the selection of appropriate, cost-effective diagnostic tests. However, in general practice, it is crucial to recognize clues that can suggest the presence of a genetic syndrome, and neonatologists often have the unique opportunity to be the first to identify abnormalities in the neonate