Proyecto arquitectónico para el centro de formación pastoral de la Parroquia Inmaculada Concepción en Santa Tecla

Se presentan 2 terrenos propiedad de la Parroquia Inmaculada Concepción, el primero de estos entre la 4ta y 6ta Av. Norte y el segundo entre el Paseo Concepción y la Calle Daniel Hernández. El primero destinado al actual Centro de formación pastoral y el segundo tiene uso comercial y de estacionamiento. El objetivo del trabajo es resolver todos los problemas espaciales y de uso en ambos terrenos, mediante la demolición de las edificaciones existentes con el fin de conseguir un nuevo centro de formación pastoral que cumpla con todas las necesidades de la feligresía de la Parroquia Inmaculada Concepció

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality