PRISMA flow diagram of diabetes and dengue.

<p>PRISMA flow diagram of diabetes and dengue.</p

Summary of case-control studies and case series.

<p>Summary of case-control studies and case series.</p

Meta-analysis of case-control studies on the association between diabetes mellitus and a severe clinical presentation of dengue.

<p>Meta-analysis of case-control studies on the association between diabetes mellitus and a severe clinical presentation of dengue.</p

Pre-defined case definitions.

<p>Pre-defined case definitions based on clinical and laboratory criteria, for each febrile illness included in the present analysis.</p

CART analyses for groups of diseases.

<p>Classification and regression trees analyses for groups of diseases. A. Bacterial disease; B. Viral disease.</p

Adjusted likelihood ratios (LR) for the predictors of each febrile illness (multivariate analysis).

<p>Results with a 95% CI that did not include 1 are in bold.</p

Crude likelihood ratios (LR) for the predictors of each febrile illness (bivariate analysis).

<p>Only results for which the LR+ was 2 and above or the LR- was 0.5 and below are provided (otherwise the cell is left empty; if not applicable, NA is mentioned). LR with a 95% confidence interval (CI) that did not include 1 are in bold.</p

CART analyses for single diseases.

<p>Classification and regression trees analyses for single diseases. A. Malaria; B. Typhoid fever; C.Urinary tract infection; D. Radiological pneumonia; E.Human Herpes Virus 6 (HHV6) infection.</p

Hospital admission rate and mortality at day 28 according to scores.

<p>Hospital admission rate and mortality at day 28 according to scores.</p

Receiver operating characteristic (ROC) curves for 28-day mortality.

<p>SOFA indicates Sequential (Sepsis-related) Organ Failure Assessment; qSOFA, quick SOFA; SIRS, systemic inflammatory response syndrome. The area under the ROC curves (AUROC) for qSOFA is 0.80 (95% CI 0.73–0.87), SOFA 0.79 (95% CI 0.71–0.87) and SIRS 0.61 (95% CI 0.52–0.71).</p