Consort Flowchart of the study.

<p>Consort Flowchart of the study.</p

Change in PC20 according to response to EVH (Individual data).

<p>Horizontal lines represent the mean. EVH+/EVH-: Subjects with/without a positive response to eucapnic voluntary hyperpnea (% fall in FEV₁ ≥ 10%); Change in PC₂₀ = Post-EVH PC₂₀—Baseline PC₂₀; DC: doubling-concentration. * p<0.05 in change in DC from baseline to post-EVH in MIT PC₂₀ in the same group. § p<0.05, §§ p<0.005 in change in DC from baseline to post-EVH in MIT PC₂₀ between two groups.</p