Exercise training improves quality of life in women with subclinical hypothyroidism : a randomized clinical trial.

Objective: The aim was to evaluate the quality of life (HRQoL) in women with subclinical hypothyroidism (sHT) after 16 weeks of endurance training. Subjects and methods: In the first phase, a cross-sectional study was conducted in which 22 women with sHT (median age: 41.5 (interquartile range: 17.5) years, body mass index: 26.2 (8.7) kg/m2 , thyroid stimulating hormone > 4.94 mIU/L and free thyroxine between 0.8 and 1.3 ng/dL were compared to a group of 33 euthyroid women concerned to HRQoL. In the second phase, a randomized clinical trial was conducted where only women with sHT were randomly divided into two groups: sHT-Tr (n = 10) ? participants that performed an exercise program ? and sHT-Sed (n = 10) ? controls. Exercise training consisted of 60 minutes of aerobic activities (bike and treadmill), three times a week, for 16 weeks. The HRQoL was assessed by the SF-36 questionnaire in the early and at the end of four months. Results: Women with sHT had lower scores on functional capacity domain in relation to the euthyroid ones (77.0 ? 23.0 vs. 88.8 ? 14.6; p = 0.020). The sHT-Tr group improved functional capacity, general health, emotional aspects, mental and physical component of HRQoL after training period, while the sHT-Sed group showed no significant changes. Conclusion: After 16 weeks of aerobic exercise training, there were remarkable improvements in HRQoL in women with sHT

Heart rate kinetics during exercise in patients with subclinical hypothyroidism.

Studies suggest that patients with subclinical hypothyroidism (SH) have sympathovagal imbalance, which could lead to a slower heart rate (HR) response in the transition from rest to exercise. Thus, the objective of this study was to investigate the behavior of the HR kinetics in patients with SH during the transition from rest to exercise. The study included 18 SH women (TSH = 6.95 ? 2.94 ?IU/mL and FT4 = 0.96 ? 0.15 ng/dl) and 17 euthyroid women (TSH = 2.28 ? 0.84 ?IU/mL and FT4 = 0.98 ? 0.07 ng/dl). Both groups were matched for physical activity, menopausal status and age. The HR kinetics was obtained during the course of a constant-load exercise (50 W), for 6 minutes, in a cycle ergometer, and quantified from the mean response time (MRT), which is equivalent to the time taken to reach 63% of the HR at steady-state. SH patients showed slower HR kinetics than the control group (MRT = 48.5 ? 17.6s vs. 36.0 ? 10.3s, p = 0.015, respectively). The MRT has been shown to correlate with the level of physical activity (r = -0.361; p = 0.033) and with the subjective perception of exertion at the end of the exercise (r = 0.365; p = 0.031). It is concluded that SH patients have slower HR kinetics in the transition from rest to exercise when compared with euthyroid women, this impairment being associated with lower levels of physical activity

Exerc?cio e qualidade de vida em mulheres idosas com hipotireoidismo tratadas com levotiroxina.

Objetivo: Testar a hip?tese de que mulheres idosas com hipotireoidismo tratadas com levotiroxina fisicamente ativas possuem melhor qualidade de vida do que pacientes sedent?rias. Material e M?todos: Participaram do estudo 27 mulheres idosas (60 a 78 anos de idade) com hipotireoidismo tratadas com levotiroxina, que foram divididas em dois grupos: fisicamente ativas (n=15) e sedent?rias (n=12). Para avaliar a qualidade de vida das participantes foi aplicado o question?rio SF-36. Resultados: As pacientes idosas fisicamente ativas apresentaram maiores valores de qualidade de vida nas dimens?es Dor (p = 0,01) e Aspectos Sociais (p = 0,03) em rela??o ?s pacientes sedent?rias. Conclus?o: Mulheres idosas com hipotireoidismo tratadas com levotiroxina fisicamente ativas apresentam qualidade de vida ligeiramente melhor quando comparadas com pacientes sedent?rias.Objective: To test the hypothesis that older women with hypothyroidism treated with levothyroxine physically active have better quality of life than sedentary patients. Material and Methods: The study included 27 older women (60-78 years old) with hypothyroidism treated with levothyroxine, which were divided into two groups: physically active (n = 15) and sedentary (n = 12). To assess the quality of life of participants the SF-36 questionnaire was applied. Results: Physically active older patients had higher values of quality of life dimensions in Pain (p = 0.01) and social aspects (p = 0.03) compared to sedentary patients. Conclusion: Elderly women with hypothyroidism treated with levothyroxine physically active have slightly better quality of life when compared to sedentary patients