DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF OLANZAPINE IN PHARMACEUTICAL DOSAGE FORMS

Background: Spectrophotometric analysis fulfills requirements where the simultaneous estimation of the drugcombination can be done with similar effectiveness as that of chromatographic methods. Simultaneousestimation of drug combination is generally done by separation using chromatographic methods like HPLC, GC, and HPTLC, etc. These methods are accurate and precise with good reproducibility, but the cost of analysis isquite high owing to expensive instrumentation, reagent, and expertise. Hence it is advisable to develop a simpler and cost-effective method for the simultaneous estimation of drugs for routine analysis of formulation.Methods: A descriptive study design was used and information was obtained through various literature reviews. RP-HPLC method was used and data were analyzed.Conclusion: The developed stability-indicating HPLC method for quantitative estimation of olanzapine in bulkand pharmaceutical dosage forms is fast, simple, accurate, and more precise. Validation of this method wasaccomplished, getting results meeting all requirements. Thus, the developed HPLC method can be used forroutine quality control tests. &nbsp

First Imaging Observation of Standing Slow Wave in Coronal Fan Loops

We observe intensity oscillations along coronal fan loops associated with the active region AR 11428. The intensity oscillations were triggered by blast waves that were generated due to X-class flares in the distant active region AR 11429. To characterize the nature of oscillations, we created time–distance maps along the fan loops and noted that the intensity oscillations at two ends of the loops were out of phase. As we move along the fan loop, the amplitude of the oscillations first decreased and then increased. The out-of-phase nature together with the amplitude variation along the loop implies that these oscillations are very likely to be standing waves. The period of the oscillations is estimated to be ~27 minutes, damping time to be ~45 minutes, and phase velocity projected in the plane of sky to be ~65–83 km s−1. The projected phase speeds were in the range of the acoustic speed of coronal plasma at about 0.6 MK, which further indicates that these are slow waves. To the best of our knowledge, this is the first report on the existence of the standing slow waves in non-flaring fan loops

Statistical Study of Plasmoids associated with post-CME Current Sheet

We investigate the properties of plasmoids observed in the current sheet formed after an X-8.3 flare followed by a fast CME eruption on September 10, 2017 using Extreme Ultraviolet (EUV) and white-light coronagraph images. The main aim is to understand the evolution of plasmoids at different spatio-temporal scales using existing ground- and space-based instruments. We identified the plasmoids in current sheet observed in the successive images of {\it Atmospheric Imaging Assembly} (AIA) and white-light coronagraphs, K-Cor and LASCO/C2. We found that the current sheet is accompanied by several plasmoids moving upwards and downwards. Our analysis showed that the downward and upward moving plasmoids have average width of 5.92 Mm and 5.65 Mm, respectively in the AIA field of view (FOV). However, upward moving plasmoids have average width of 64 Mm in the K-Cor which evolves to a mean width of 510 Mm in the LASCO/C2 FOV. Upon tracking the plasmoids in successive images, we observe that downward and upward moving plasmoids have average speeds of $\sim$272 km s$^{-1}$ and $\sim$191 km s$^{-1}$ respectively in the EUV passbands. We note that the plasmoids become super-Alfv\'enic when they reach at LASCO FOV. Furthermore, we estimate that the null-point of the current sheet at $\approx$ 1.15 R$_\odot$ where bidirectional plasmoid motion is observed. We study the width distribution of plasmoids formed and notice that it is governed by a power law with a power index of -1.12. Unlike previous studies there is no difference in trend for small and large scale plasmoids. The presence of accelerating plasmoids near the neutral point indicates a longer diffusion region as predicted by MHD models.Comment: Accepted for the publication in Astronomy & Astrophysics (A&A). 10 pages, 11 figures. Animations can be found at https://www.dropbox.com/sh/g0wjq2awxai1hy4/AAClkTHPFkTa5JU-Zulf9a75a?dl=