1 research outputs found
Oligo-β-(1 → 3)-glucans: Impact of Thio-Bridges on Immunostimulating Activities and the Development of Cancer Stem Cells
Recent
developments of innovative anticancer therapies are based
on compounds likely to stimulate the immune defense of the patients.
β-(1 → 3)-Glucans are natural polysaccharides well-known
for their immunostimulating properties. We report here on the synthesis
of small oligo-β-(1 → 3)-glucans characterized by thioglycosidic
linkages. The presence of sulfur atom(s) was not only crucial to prolong
in vivo immunoactive activities in time, compared to native polysaccharides,
but sulfur atoms also had a direct impact on the development of colorectal
cancer stem cells. As a result, a short, pure, and structurally well-defined
trisaccharidic thioglucan demonstrated similar activities compared
to those of natural laminarin