Familon Model of Dark Matter

If the next fundamental level of matter occurs (preons) then dark matter must consist of familons containing a "hot" component from massless particles and a "cold" component from massive particles. During evolution of the Universe this dark matter was undergone to late-time relativistic phase transitions temperatures of which were different. Fluctuations created by these phase transitions have had a fractal character. In the result the structurization of dark matter (and therefore the baryon subsystem) has taken place and in the Universe some characteristic scales which have printed this phenomenon arise naturally. Familons are collective excitations of nonperturbative preon condensates which could be produced during more early relativistic phase transition. For structurization of dark matter (and baryon component) three generations of particles are necessary. The first generation of particles has produced the observed baryon world. The second and third generations have produced dark matter from particles which have appeared when symmetry among generations was spontaneously broken.Comment: 12 page

Expression of the BCR-ABL1 Gene in Patients with Chronic Myeloproliferative Diseases with Signs of Progression

Background. The V617F mutation of JAK2 is known to manifest in Ph-negative chronic myeloproliferative diseases (cMPD), such as polycythemia vera, thrombocythemia, and myelofibrosis. These diseases not infrequently advance into more aggressive forms up to acute leukemia. As the progression mechanism is still unknown, its study retains a high priority. JAK2 carrying the V617F mutation is believed to cause constant activation of V(D)J recombinase in myeloid tumor cells in cMPD patients. Aberrant activation of V(D)J recombinase in tumor cells in cMPD patients can lead to t(9;22)(q34;q11) chromosomal rearrangement. Aim. To study the expression of BCR-ABL1 resulting from translocation t(9;22)(q34;q11) in cMPD patients at the progression stage in order to test the suggested hypothesis. Materials & Methods. The BCR–ABL1 expression was assessed in peripheral blood granulocytes in cMPD patients by real-time PCR. The JAK2 V617F mutation was identified by quantitative allele-specific PCR. The JAK2 exon 12 mutations were determined using Sanger direct sequencing of PCR products. Results. The BCR-ABL1 expression was discovered in 29 % of patients with cMPD progression. The BCR-ABL1 expression in these patients correlated with hepatosplenomegaly and hyperleukocytosis. Conclusion. In a significant proportion of cMPD patients the disease progression can be associated with activation of the BCR-ABL expression

A critique of methods for temperature imaging in single cells

International audienceWe argue that standard thermodynamic considerations and scaling laws show that a single cell cannot substantially raise its temperature by endogenous thermogenesis. This statement seriously questions the interpretations of recent work reporting temperature heterogeneities measured in single living cells