14 research outputs found
Effect of <i> Morus alba</i> L. (mulberry) leaves on anxiety in mice
OBJECTIVE: The aim of the present work is to evaluate the anxiolytic effect of a methanolic extract of Morus alba L. leaves in mice. MATERIALS AND METHODS: The hole-board test, elevated plus-maze paradigm, open field test, and light/dark paradigm were used to assess the anxiolytic activity of the methanolic extract of M. alba L. Morus alba extract (50, 100, and 200 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.) were administered 30 min before the tests. RESULTS: The results showed that the methanolic extract of M. alba significantly increased the number and duration of head poking in the hole-board test. In the elevated plus-maze, the extract significantly increased the exploration of the open arm in similar way to that of diazepam. At a dose of 200 mg/kg i.p. the extract significantly increased both the time spent in and the entries into the open arm by mice. Further, in the open field test, the extract significantly increased rearing, assisted rearing, and number of squares traversed, all of which are demonstrations of exploratory behavior. In the light/dark paradigm, the extract produced significant increase in time spent in the lighted box as compared to vehicle. The spontaneous locomotor activity count, measured using an actophotometer, was significantly decreased in animals pretreated with M. alba extract, indicating a remarkable sedative effect of the plant. CONCLUSION: The results of the present study suggest that a methanolic extract of M. alba leaves may possess an anxiolytic effect
Effect of Morus alba L. (mulberry) leaves on anxiety in mice
Objective: The aim of the present work is to evaluate the anxiolytic
effect of a methanolic extract of Morus alba L. leaves in
mice. Materials and Methods: The hole-board test, elevated plus-maze
paradigm, open field test, and light/dark paradigm were used to assess
the anxiolytic activity of the methanolic extract of M. alba L. Morus
alba extract (50, 100, and 200 mg/kg, i.p.) and diazepam (1 mg/kg,
i.p.) were administered 30 min before the tests. Results: The results
showed that the methanolic extract of M. alba significantly increased
the number and duration of head poking in the hole-board test. In the
elevated plus-maze, the extract significantly increased the exploration
of the open arm in similar way to that of diazepam. At a dose of 200
mg/kg i.p. the extract significantly increased both the time spent in
and the entries into the open arm by mice. Further, in the open field
test, the extract significantly increased rearing, assisted rearing,
and number of squares traversed, all of which are demonstrations of
exploratory behavior. In the light/dark paradigm, the extract produced
significant increase in time spent in the lighted box as compared to
vehicle. The spontaneous locomotor activity count, measured using an
actophotometer, was significantly decreased in animals pretreated with
M. alba extract, indicating a remarkable sedative effect of the plant.
Conclusion: The results of the present study suggest that a methanolic
extract of M. alba leaves may possess an anxiolytic effect