Do internal software quality tools measure validated metrics?

Internal software quality determines the maintainability of the software product and influences the quality in use. There is a plethora of metrics which purport to measure the internal quality of software, and these metrics are offered by static software analysis tools. To date, a number of reports have assessed the validity of these metrics. No data are available, however, on whether metrics offered by the tools are somehow validated in scientific studies. The current study covers this gap by providing data on which tools and how many validated metrics are provided. The results show that a range of metrics that the tools provided do not seem to be validated in the literature and that only a small percentage of metrics are validated in the provided tools

Verifying 4D gated radiotherapy using time-integrated electronic portal imaging: a phantom and clinical study

<p>Abstract</p> <p>Background</p> <p>Respiration-gated radiotherapy (RGRT) can decrease treatment toxicity by allowing for smaller treatment volumes for mobile tumors. RGRT is commonly performed using external surrogates of tumor motion. We describe the use of time-integrated electronic portal imaging (TI-EPI) to verify the position of internal structures during RGRT delivery</p> <p>Methods</p> <p>TI-EPI portals were generated by continuously collecting exit dose data (aSi500 EPID, Portal vision, Varian Medical Systems) when a respiratory motion phantom was irradiated during expiration, inspiration and free breathing phases. RGRT was delivered using the Varian RPM system, and grey value profile plots over a fixed trajectory were used to study object positions. Time-related positional information was derived by subtracting grey values from TI-EPI portals sharing the pixel matrix. TI-EPI portals were also collected in 2 patients undergoing RPM-triggered RGRT for a lung and hepatic tumor (with fiducial markers), and corresponding planning 4-dimensional CT (4DCT) scans were analyzed for motion amplitude.</p> <p>Results</p> <p>Integral grey values of phantom TI-EPI portals correlated well with mean object position in all respiratory phases. Cranio-caudal motion of internal structures ranged from 17.5–20.0 mm on planning 4DCT scans. TI-EPI of bronchial images reproduced with a mean value of 5.3 mm (1 SD 3.0 mm) located cranial to planned position. Mean hepatic fiducial markers reproduced with 3.2 mm (SD 2.2 mm) caudal to planned position. After bony alignment to exclude set-up errors, mean displacement in the two structures was 2.8 mm and 1.4 mm, respectively, and corresponding reproducibility in anatomy improved to 1.6 mm (1 SD).</p> <p>Conclusion</p> <p>TI-EPI appears to be a promising method for verifying delivery of RGRT. The RPM system was a good indirect surrogate of internal anatomy, but use of TI-EPI allowed for a direct link between anatomy and breathing patterns.</p

Abrogation of Cbl–PI3K Interaction Increases Bone Formation and Osteoblast Proliferation

Cbl is an adaptor protein and E3 ligase that plays both positive and negative roles in several signaling pathways that affect various cellular functions. Tyrosine 737 is unique to Cbl and phosphorylated by Src family kinases. Phosphorylated CblY737 creates a binding site for the p85 regulatory subunit of phosphatidylinositol 3 kinase (PI3K) that also plays an important role in the regulation of bone homeostasis. To investigate the role of Cbl–PI3K interaction in bone homeostasis, we examined knock-in mice in which the PI3K binding site on Cbl was ablated due to the substitution of tyrosine 737 to phenylalanine (CblYF/YF, YF mice). We previously reported that bone volume in these mice is increased due to decreased osteoclast function (Adapala et al., J Biol Chem 285:36745–36758, 19). Here, we report that YF mice also have increased bone formation and osteoblast numbers. In ex vivo cultures bone marrow-derived YF osteoblasts showed increased Col1A expression and their proliferation was also significantly augmented. Moreover, proliferation of MC3T3-E1 cells was increased after treatment with conditioned medium generated by culturing YF bone marrow stromal cells. Expression of stromal derived factor-1 (SDF-1) was increased in YF bone marrow stromal cells compared to wild type. Increased immunostaining of SDF-1 and CXCR4 was observed in YF bone marrow stromal cells compared to wild type. Treatment of YF condition medium with neutralizing anti-SDF-1 and anti-CXCR4 antibodies attenuated MC3T3-E1 cell proliferation. Cumulatively, these results show that abrogation of Cbl–PI3K interaction perturbs bone homeostasis, affecting both osteoclast function and osteoblast proliferation

Study Protocol - Accurate assessment of kidney function in Indigenous Australians: aims and methods of the eGFR Study

Background: There is an overwhelming burden of cardiovascular disease, type 2 diabetes and chronic kidney disease among Indigenous Australians. In this high risk population, it is vital that we are able to measure accurately kidney function. Glomerular filtration rate is the best overall marker of kidney function. However, differences in body build and body composition between Indigenous and non-Indigenous Australians suggest that creatinine-based estimates of glomerular filtration rate derived for European populations may not be appropriate for Indigenous Australians. The burden of kidney disease is borne disproportionately by Indigenous Australians in central and northern Australia, and there is significant heterogeneity in body build and composition within and amongst these groups. This heterogeneity might differentially affect the accuracy of estimation of glomerular filtration rate between different Indigenous groups. By assessing kidney function in Indigenous Australians from Northern Queensland, Northern Territory and Western Australia, we aim to determine a validated and practical measure of glomerular filtration rate suitable for use in all Indigenous Australians

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Not AvailableCurrent study provides information on Length–weight relationship (LWR) of four fish species of family Mugilidae i.e., Planiliza macrolepis (Smith, 1846), Chelon parsia (Hamilton, 1822), Osteomugil cunnesius (Valenciennes, 1836) and Valamugil speigleri (Bleeker, 1858) from Chilika Lagoon, East coast of India. Samples were collected during monsoon (July 2016), winter (November 2016) and summer (April 2017) seasons from the fisher's boats inside the lagoon while fishing with screen barrier nets (mesh size 18‐38 mm) and gill nets (mesh size 34, 38, 46, 62 and 86 mm). The b values were determined from the data set in LWRs as 2.958 for P. macrolepis, 2.952 for O. cunnesius and 2.919 for C. parsia and 2.883 for V. peigleri. In all species, regression values were statistically significant (p < .05).Not Availabl

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Not AvailableHealth of the Hooghly estuary was estimated through Water Quality Index (WQI) developed using ten water quality parameters, viz., specific conductivity, turbidity, pH, total dissolved solids, dissolved oxygen, biochemical oxygen demand, chloride, total alkalinity, total hardness, and nitrate-N measured at three different stations along the salinity gradient. Weighted arithmetic index method was used for calculation of WQI. For classifying water quality in each of the sampling stations, five-point rating scale was used. Wide fluctuations in monthly WQI were observed in this estuarine zone with the highest values during pre-monsoon month of May and the lowest values during monsoon month of October. From WQI values (mostly >100) throughout the year, it was evident that Hooghly-Bhagirathi estuarine system is unsuitable for drinking and propagation of wildlife and freshwater aqua culture as per water quality standards. It was also observed that there is a severe anthropogenic influence on most of the parameters. Major causes of deterioration in water quality were discharge of untreated industrial and municipal wastes, besides high level of other anthropogenic activities.Key words WQI; Hooghly estuary; IndiaNot Availabl

A comparative study of HoSn1.1Ge0.9 and DySn1.1Ge0.9 compounds using magnetic, magneto-thermal and magneto-transport measurements

Polycrystalline HoSn1.1Ge0.9 and DySn1.1Ge0.9 compounds have been studied by means of different experimental probes. Both the compounds are antiferromagnetic and show metamagnetic transition at low temperatures. HoSn1.1Ge0.9 shows a sign change in magnetocaloric effect (MCE) and magnetoresistance (MR) with field, which is attributed to the metamagnetic transition. DySn1.1Ge0.9 shows characteristics of a typical antiferromagnet, as evidenced by magnetization, MCE and MR data. Sn-119 Mosbauer sudies show hyperfine splitting at low temperatures, consistent with magnetization data. Thermoelectric power and resistivity measurements reveal metallic behavior in these compounds. Magnetic, magnetocaloric and the magnetoresistance data clearly show that the antiferromagnetic coupling in DySn1.1Ge0.9 is stronger than in HoSn1.1Ge0.9. (C) 2014 Elsevier B. V. All rights reserved