Cosmic rays studied with a hybrid high school detector array

The LORUN/NAHSA system is a pathfinder for hybrid cosmic ray research combined with education and outreach in the field of astro-particle physics. Particle detectors and radio antennae were mainly setup by students and placed on public buildings. After fully digital data acquisition, coincidence detections were selected. Three candidate events confirmed a working prototype, which can be multiplied to extend further particle detector arrays on high schools.Comment: 10 pages, 6 figures. Nigl, A., Timmermans, C., Schellart, P., Kuijpers, J., Falcke, H., Horneffer, A., de Vos, C. M., Koopman, Y., Pepping, H. J., Schoonderbeek, G., Cosmic rays studied with a hybrid high school detector array, Europhysics News (EPN), Vol. 38, No. 5, accepted on 22/08/200

A Comparative Study of the Valence Electronic Excitations of N_2 by Inelastic X-ray and Electron Scattering

Bound state, valence electronic excitation spectra of N_2 are probed by nonresonant inelastic x-ray and electron scattering. Within the usual theoretical treatments, dynamical structure factors derived from the two probes should be identical. However, we find strong disagreements outside the dipole scattering limit, even at high probe energies. This suggests an unexpectedly important contribution from intra-molecular multiple scattering of the probe electron from core electrons or the nucleus. These effects should grow progressively stronger as the atomic number of the target species increases.Comment: Submitted to Physical Review Letters April 27, 2010. 12 pages including 2 figure pages

A systematic review of the energy and climate impacts of teleworking

Information and communication technologies (ICTs) increasingly enable employees to work from home and other locations (‘teleworking’). This study explores the extent to which teleworking reduces the need to travel to work and the consequent impacts on economy-wide energy consumption. Methods/Design: The paper provides a systematic review of the current state of knowledge of the energy impacts of teleworking. This includes the energy savings from reduced commuter travel and the indirect impacts on energy consumption associated with changes in non-work travel and home energy consumption. The aim is to identify the conditions under which teleworking leads to a net reduction in economy-wide energy consumption, and the circumstances where benefits may be outweighed by unintended impacts. The paper synthesises the results of 39 empirical studies, identified through a comprehensive search of 9,000 published articles. Review results/Synthesis: Twenty six of the 39 studies suggest that teleworking reduces energy use, and only eight studies suggest that teleworking increases, or has a neutral impact on energy use. However, differences in the methodology, scope and assumptions of the different studies make it difficult to estimate ‘average’ energy savings. The main source of savings is the reduced distance travelled for commuting, potentially with an additional contribution from lower office energy consumption. However, the more rigorous studies that include a wider range of impacts (e.g. non-work travel or home energy use) generally find smaller savings. Discussion: Despite the generally positive verdict on teleworking as an energy-saving practice, there are numerous uncertainties and ambiguities about its actual or potential benefits. These relate to the extent to which teleworking may lead to unpredictable increases in non-work travel and home energy use that may outweigh the gains from reduced work travel. The available evidence suggests that economy-wide energy savings are typically modest, and in many circumstances could be negative or non-existent

Physics Behind Precision

This document provides a writeup of contributions to the FCC-ee mini-workshop on "Physics behind precision" held at CERN, on 2-3 February 2016.Comment: https://indico.cern.ch/event/469561

Structure of the Cytoplasmic Loop between Putative Helices II and III of the Mannitol Permease of Escherichia coli: A Tryptophan and 5-Fluorotryptophan Spectroscopy Study

In this work, four single tryptophan (Trp) mutants of the dimeric mannitol transporter of Escherichia coli, EIImtl, are characterized using Trp and 5-fluoroTrp (5-FTrp) fluorescence spectroscopy. The four positions, 97, 114, 126, and 133, are located in a region shown by recent studies to be involved in the mannitol translocation process. To spectroscopically distinguish between the Trp positions in each subunit of dimeric EIImtl, 5-FTrp was biosynthetically incorporated because of its much simpler photophysics compared to those of Trp. The steady-state and time-resolved fluorescence methodologies used point out that all four positions are in structured environments, both in the absence and in the presence of a saturating concentration of mannitol. The fluorescence decay of all 5-FTrp-containing mutants was highly homogeneous, suggesting similar microenvironments for both probes per dimer. However, Stern-Volmer quenching experiments using potassium iodide indicate different solvent accessibilities for the two probes at positions 97 and 133. A 5 Å two-dimensional (2D) projection map of the membrane-embedded IICmtl dimer showing 2-fold symmetry is available. The results of this work are in better agreement with a 7 Å projection map from a single 2D crystal on which no symmetry was imposed.

Resonance-Induced Effects in Photonic Crystals

For the case of a simple face-centered-cubic photonic crystal of homogeneous dielectric spheres, we examine to what extent single-sphere Mie resonance frequencies are related to band gaps and whether the width of a gap can be enlarged due to nearby resonances. Contrary to some suggestions, no spectacular effects may be expected. When the dielectric constant of the spheres $\epsilon_s$ is greater than the dielectric constant $\epsilon_b$ of the background medium, then for any filling fraction $f$ there exists a critical $\epsilon_c$ above which the lowest lying Mie resonance frequency falls inside the lowest stop gap in the (111) crystal direction, close to its midgap frequency. If $\epsilon_s <\epsilon_b$, the correspondence between Mie resonances and both the (111) stop gap and a full gap does not follow such a regular pattern. If the Mie resonance frequency is close to a gap edge, one can observe a resonance-induced widening of a relative gap width by $\approx 5$.Comment: 14 pages, 3 figs., RevTex. For more info look at http://www.amolf.nl/external/wwwlab/atoms/theory/index.htm

The clinical response to infliximab in rheumatoid arthritis is in part dependent on pretreatment tumour necrosis factor α expression in the synovium

Objective: To determine whether the heterogeneous clinical response to tumour necrosis factor (TNF)alpha blocking therapy in rheumatoid arthritis (RA) can be predicted by TNF alpha expression in the synovium before initiation of treatment. Methods: Prior to initiation of infliximab treatment, arthroscopic synovial tissue biopsies were obtained from 143 patients with active RA. At week 16, clinical response was evaluated using the 28-joint Disease Activity Score (DAS28). Immunohistochemistry was used to analyse the cell infiltrate as well as the expression of various cytokines, adhesion molecules and growth factors. Stained sections were evaluated by digital image analysis. Student t tests were used to compare responders (decrease in DAS28 >= 1.2) with non-responders (decrease in DAS28 <1.2) and multivariable regression was used to identify the independent predictors of clinical response. Results: Synovial tissue analysis confirmed our hypothesis that the baseline level of TNF alpha expression is a significant predictor of response to TNF alpha blocking therapy. TNF alpha expression in the intimal lining layer and synovial sublining were significantly higher in responders than in non-responders (p = 0.047 and p = 0.008, respectively). The numbers of macrophages, macrophage subsets and T cells (all able to produce TNF alpha) were also significantly higher in responders than in non-responders. The expression of interleukin (IL)1 beta, IL6, IL18, IL10, E-selectin, intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) was not associated with response to anti-TNF alpha treatment. Conclusion: The effects of TNF alpha blockade are in part dependent on synovial TNF alpha expression and infiltration by TNF alpha producing inflammatory cells. Clinical response cannot be predicted completely, indicating involvement of other as yet unknown mechanism

Gravity-mode period spacings as seismic diagnostic for a sample of gamma Doradus stars from Kepler space photometry and high-resolution ground-based spectroscopy

Gamma Doradus stars (hereafter gamma Dor stars) are gravity-mode pulsators of spectral type A or F. Such modes probe the deep stellar interior, offering a detailed fingerprint of their structure. Four-year high-precision space-based Kepler photometry of gamma Dor stars has become available, allowing us to study these stars with unprecedented detail. We selected, analysed, and characterized a sample of 67 gamma Dor stars for which we have Kepler observations available. For all the targets in the sample we assembled high-resolution spectroscopy to confirm their F-type nature. We found fourteen binaries, among which four single-lined binaries, five double-lined binaries, two triple systems and three binaries with no detected radial velocity variations. We estimated the orbital parameters whenever possible. For the single stars and the single-lined binaries, fundamental parameter values were determined from spectroscopy. We searched for period spacing patterns in the photometric data and identified this diagnostic for 50 of the stars in the sample, 46 of which are single stars or single-lined binaries. We found a strong correlation between the spectroscopic vsini and the period spacing values, confirming the influence of rotation on gamma Dor-type pulsations as predicted by theory. We also found relations between the dominant g-mode frequency, the longest pulsation period detected in series of prograde modes, vsini, and log Teff.Comment: 61 pages, 61 figures, 6 tables, accepted for publication in ApJ

Coastal Management: A guide to using archaeological, palaeoenvironmental, historical and artistic resources

This ‘Guide’ has been produced as part of the project ‘Archaeology, art and coastal heritage: tools to support coastal management and climate change planning across the Channel Regional Sea’ (Arch-Manche). It details how data sources have been identified, ranked and analysed together to provide evidence of coastal change. Experiences of deploying a range of field investigation techniques to gather scientific data supporting understanding of past coastal change are detailed. The importance of this work in relation to coastal management is presented through a range of results from case studies within areas exhibiting different physical and geomorphological characteristics. The results demonstrate the asyet unrealised potential within archaeological, paleoenvironmental, historical and artistic resources to inform on the scale and pace of coastal change