8 research outputs found
Effect of combined exercise training on physical and metabolic fitness in adults with intellectual disability: a controlled trial
Effects of exercise on the physical fitness level of adults with intellectual disability: a systematic review
Physical activity for individuals with Down syndrome. A review with clinical implications
Alterações na composição corporal decorrentes de um treinamento de musculação em portadores de sĂndrome de Down
The Effect of Systematic Prompting on the Acquisition of Two Muscle-Strengthening Exercises by Adults with Moderate Intellectual Disabilities
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Muscle stem cell dysfunction impairs muscle regeneration in a mouse model of Down syndrome
Abstract Down syndrome, caused by trisomy 21, is characterized by a variety of medical conditions including intellectual impairments, cardiovascular defects, blood cell disorders and pre-mature aging phenotypes. Several somatic stem cell populations are dysfunctional in Down syndrome and their deficiencies may contribute to multiple Down syndrome phenotypes. Down syndrome is associated with muscle weakness but skeletal muscle stem cells or satellite cells in Down syndrome have not been investigated. We find that a failure in satellite cell expansion impairs muscle regeneration in the Ts65Dn mouse model of Down syndrome. Ts65Dn satellite cells accumulate DNA damage and over express Usp16, a histone de-ubiquitinating enzyme that regulates the DNA damage response. Impairment of satellite cell function, which further declines as Ts65Dn mice age, underscores stem cell deficiencies as an important contributor to Down syndrome pathologies