Diastolic And Systolic Right Ventricular Dysfunction Precedes Left Ventricular Dysfunction In Patients Paced From Right Ventricular Apex

Background: Cardiac dysfunction after right ventricular (RV) apical pacing is well known but its extent, time frame of appearance and individual effect on left ventricular (LV), RV systolic and diastolic parameters has not evaluated in a systematic fashion. Methods: Patients with symptomatic bradycardia and ACC-AHA Class I indication for permanent pacemaker implantation (PPI) were implanted a single chamber (VVI) pacemaker. They were followed prospectively by echocardiographic examination which was done at baseline, 1 week, 1 month and 6 months after implantation. Parameters observed were chamber dimensions (M-line), chamber volumes, cardiac output (modified Simpson's method), systolic functions (ejection fraction, pre-ejection period, ejection time and ratio) and diastolic functions( isovolumic relaxation time & deceleration time) of left and right heart. Results: Forty eight consecutive patients (mean age 65.6±11.8 yrs, 66.7% males, mean EF 61.82±10.36%) implanted a VVI pacemaker were enrolled in this study. The first significant change to appear in cardiac function after VVI pacing was in diastolic properties of RV as shown by increase in RV isovolumic relaxation time (IVRT) from 65.89±15.93 to 76.58±17.00 ms,(p<0.001) at 1week and RV deceleration time (DT) from 133.84±38.13 to 153.09±31.41 ms, (p=0.02) at 1 month. Increase in RV internal dimension (RVID) from 1.26±0.41 to 1.44±0.44, (p<0.05) was also noticed at 1 week. The LV diastolic parameters were significantly altered after 1 month with increase in LV-IVRT from 92.36±21.47 to 117.24±27.21ms, (p<0.001) and increase in LV DT from 147.56±31.84 to 189.27±28.49ms,(p<0.01). This was followed by LV systolic abnormality which appeared at 6 months with an increase in LVPEP from 100.33±14.43 to 118.41±21.34ms, (p<0.001) and increase in LVPEP/LVET ratio from 0.34±0.46 to 0.44±0.10, (p<0.001)]. The reduction in LV EF was manifested at 6 months falling from 61.82±10.36% to52.52±12.11%, (p<0.05) without any significant change in the resting cardiac output. Conclusion: The present study shows that dysfunction of right ventricle is the first abnormality that occurs in VVI paced patients, which manifests by 1 week followed by LV dysfunction which starts appearing by 1 month and the diastolic dysfunctions precede the systolic dysfunction in both ventricles

Foliar sprays of concentrated urea at maturity of pigeonpea to induce defoliation and increase its residual benefit to wheat

The pigeonpea (Cajanus cajan (L.) Millsp.) crop retains appreciable amounts of green foliage even after reaching physiological maturity, which if allowed to defoliate, could augment the residual benefit of pigeonpea to the following wheat (Triticum aestivum L.) in a pigeonpea–wheat rotation. The effect of addition of leaves present on mature pigeonpea crop to the soil was examined on the following wheat during the 1999/2000 growing season at Patancheru (17840N, 78820E) and during the 2001–2003 growing seasons at Modipuram (29840N, 77880E). At Patancheru, an extra-short-duration pigeonpea cultivar ICPL 88039 was defoliated manually and using foliar sprays of 10% urea (30 kg/ha) and compared with a millet (Pennisetum glaucum (L.) R.Br.) crop, naturally senesced leaf residue and no-leaf residue controls. At Modipuram, the effect of 10% urea spray treatment on mature ICPL 88039 was compared with the unsprayed control. At both locations, the rainy season crops were followed by a wheat cultivar UP 2338 at four nitrogen levels applied in a split plot design, which at Patancheru were 0, 30, 90 and 120 kg N ha 1 and at Modipuram 0, 60, 120 and 180 kg N ha 1. At Patancheru, urea spray added 0.5 t ha 1 of extra leaf litter to the soil within a week without significantly affecting pigeonpea yield. This treatment, however, increased mean wheat yield by 29% from 2.4 t ha 1 in the no-leaf residue pigeonpea or pearl millet plots to 3.1 t ha 1. At Modipuram, the foliar sprays of urea added more leaf litter to the soil than at Patancheru. Here, increase in subsequent wheat yield due to additional pigeonpea leaf litter was 7–8% and net profit 21% more than in the unsprayed control. The addition of pigeonpea leaf litter to the soil resulted in a saving of 40–60 kg N for the following wheat crops in both the environments. The results demonstrated that pigeonpea leaf litter could play an important role in the fertilizer N economy in wheat. The urea spray at maturity of the standing pigeonpea crop significantly improved this contribution in increasing wheat yield, the effect of which was additional to the amount of urea used for inducing defoliation. The practice, if adopted by farmers, may enhance sustainability of wheat production system in an environmentally friendly way, as it could reduce the amount of fertilizer N application to soil and enhance wheat yield

Diversification of rice with pigeonpea in a rice-wheat cropping system on a Typic Ustochrept: effect on soil fertility, yield and nutrient use efficiency

Continuous adoption of rice-wheat cropping system (RWCS) has led to depletion of inherent soil fertility resulting in a serious threat to its sustainability in the Indo-Gangetic plain region (IGPR) of India. The inclusion of legumes in RWCS assumes a great significance to restore soil fertility. But farmers in the IGPR rarely grow legumes in the system. We, therefore, carried out farmers' participatory diagnostic survey in the Upper Gangetic plain zone (UGP) to understand farmers' fertilizer management practices for wheat (Trititicum aestivum L. Emend Fiori & Paol) following rice (Oryza sativa L.) or pigeonpea (Cajanus cajan (L.) Millsp). The survey indicated that most of the farmers in UGP grew pigeonpea in place of rice under RWCS as only a break crop at a 2-3 year interval. The farmers applied, on average, 11 kg N ha-1 and 24 kg P ha-1 to wheat sown after rice, and 12 kg N ha-1 and 19 kg P ha-1 to wheat sown after pigeonpea. Wheat yields, however, were lower (3.3 t ha-1) when sown after pigeonpea than after rice (3.7 t ha-1). The survey was followed by a field experiment at Modipuram (29°4′N), Meerut, India that continued during the three consecutive years (1998-1999 to 2000-2001) to examine the effect of inclusion of pigeonpea in place of rice on soil fertility, N and P use efficiency and yields of wheat. In 1998-1999, wheat yields after pigeonpea were lower than after rice, but improved significantly (p<0.05) by 11.4-15.1% in pigeonpea plots compared with those in rice plots during 1999-2000 and 2000-2001, respectively. The use efficiency of applied N and P fertilizers in wheat, measured as agronomic efficiency and apparent recovery, was increased with combined use of fertilizer N and P at recommended rate, and also with inclusion of pigeonpea in place of rice. The post-wheat harvest NO3-N in soil profile beyond 45 cm depth was significantly greater under rice-wheat system than under pigeonpea-wheat system, suggesting that inclusion of pigeonpea may help in minimizing NO3-N leaching to deeper profile layers beyond root zone. Similarly, in the treatments receiving both 120 kg N and 26 kg P ha-1, NO3-N beyond 45 cm soil depth was lower compared to those receiving N or P alone. Inclusion of pigeonpea in place of rice enhanced carbon accumulation in the soil profile. The available P content was, however, invariably low under pigeonpea plots as compared to that under rice. With continuous rice-wheat cropping, the bulk density (BD) of soil was increased, especially in the 30-45 cm soil profile. Inclusion of pigeonpea in the system not only helped maintaining soil BD at initial level in the surface (0-15 cm) soil layers, but also in decreasing (p<0.05) BD in sub-surface layers (15-30 cm and 30-45 cm). Compared to rice, a statistically significant (p<0.05) positive effect of pigeonpea on root volume (58%) and root weight (99.5%) of succeeding wheat was also recorded. The net economic returns under pigeonpea-wheat system were greater compared with rice-wheat syste

Harmful and beneficial aspects of Parthenium hysterophorus: an update

Parthenium hysterophorus is a noxious weed in America, Asia, Africa and Australia. This weed is considered to be a cause of allergic respiratory problems, contact dermatitis, mutagenicity in human and livestock. Crop production is drastically reduced owing to its allelopathy. Also aggressive dominance of this weed threatens biodiversity. Eradication of P. hysterophorus by burning, chemical herbicides, eucalyptus oil and biological control by leaf-feeding beetle, stem-galling moth, stem-boring weevil and fungi have been carried out with variable degrees of success. Recently many innovative uses of this hitherto notorious plant have been discovered. Parthenium hysterophorus confers many health benefits, viz remedy for skin inflammation, rheumatic pain, diarrhoea, urinary tract infections, dysentery, malaria and neuralgia. Its prospect as nano-medicine is being carried out with some preliminary success so far. Removal of heavy metals and dye from the environment, eradication of aquatic weeds, use as substrate for commercial enzyme production, additives in cattle manure for biogas production, as biopesticide, as green manure and compost are to name a few of some other potentials. The active compounds responsible for hazardous properties have been summarized. The aim of this review article is to explore the problem P. hysterophorus poses as a weed, the effective control measures that can be implemented as well as to unravel the latent beneficial prospects of this weed

MAK-4 and -5 supplemented diet inhibits liver carcinogenesis in mice

<p>Abstract</p> <p>Background</p> <p>Maharishi Amrit Kalash (MAK) is an herbal formulation composed of two herbal mixtures, MAK-4 and MAK-5. These preparations are part of a natural health care system from India, known as Maharishi Ayur-Veda. MAK-4 and MAK-5 are each composed of different herbs and are said to have maximum benefit when used in combination. This investigation evaluated the cancer inhibiting effects of MAK-4 and MAK-5, <it>in vitro </it>and <it>in vivo</it>.</p> <p>Methods</p> <p><it>In vitro </it>assays: Aqueous extracts of MAK-4 and MAK-5 were tested for effects on <it>ras </it>induced cell transformation in the Rat 6 cell line assessed by focus formation assay. <it>In vivo </it>assays: Urethane-treated mice were put on a standard pellet diet or a diet supplemented with MAK-4, MAK-5 or both. At 36 weeks, livers were examined for tumors, sera for oxygen radical absorbance capacity (ORAC), and liver homogenates for enzyme activities of glutathione peroxidase (GPX), glutathione-S-transferase (GST), and NAD(P)H: quinone reductase (QR). Liver fragments of MAK-fed mice were analyzed for connexin (cx) protein expression.</p> <p>Results</p> <p>MAK-5 and a combination of MAK-5 plus MAK-4, inhibited <it>ras</it>-induced cell transformation. In MAK-4, MAK-5 and MAK4+5-treated mice we observed a 35%, 27% and 46% reduction in the development of urethane-induced liver nodules respectively. MAK-4 and MAK4+5-treated mice had a significantly higher ORAC value (<it>P </it>< 0.05) compared to controls (200.2 ± 33.7 and 191.6 ± 32.2 <it>vs. </it>152.2 ± 15.7 ORAC units, respectively). The urethane-treated MAK-4, MAK-5 and MAK4+5-fed mice had significantly higher activities of liver cytosolic enzymes compared to the urethane-treated controls and to untreated mice: GPX(0.23 ± 0.08, 0.21 ± 0.05, 0.25 ± 0.04, 0.20 ± 0.05, 0.21 ± 0.03 U/mg protein, respectively), GST (2.0 ± 0.4, 2.0 ± 0.6, 2.1 ± 0.3, 1.7 ± 0.2, 1.7 ± 0.2 U/mg protein, respectively) and QR (0.13 ± 0.02, 0.12 ± 0.06, 0.15 ± 0.03, 0.1 ± 0.04, 0.11 ± 0.03 U/mg protein, respectively). Livers of MAK-treated mice showed a time-dependent increased expression of cx32.</p> <p>Conclusion</p> <p>Our results show that a MAK-supplemented diet inhibits liver carcinogenesis in urethane-treated mice. The prevention of excessive oxidative damage and the up-regulation of connexin expression are two of the possible effects of these products.</p