2 research outputs found
Asymmetric Synthesis of Tertiary Alcohols and Thiols via Nonstabilized Tertiary α-Oxy- and α-Thio-Substituted Organolithium Species
Nonstabilized αâOâsubstituted tertiary organolithium species are difficult to generate, and the αâSâsubstituted analogues are configurationally unstable. We now report that they can both be generated easily and trapped with a range of electrophiles with high enantioselectivity, providing ready access to a range of enantioenriched tertiary alcohols and thiols. The configurational stability of the αâSâorganolithium species was enhanced by using a less coordinating solvent and short reaction times
Stereospecific conversion of alcohols into pinacol boronic esters using lithiationâborylation methodology with pinacolborane
The synthesis of primary and secondary pinacol boronic esters via
lithiationâborylation of carbamates and benzoates with pinacolborane is described. This new protocol enables the highly selective
synthesis of enantioenriched and geometrically defined boronic esters
that cannot otherwise be accessed by alternative methodologies