Congenital hypothyroidism

Congenital hypothyroidism (CH) occurs in approximately 1:2,000 to 1:4,000 newborns. The clinical manifestations are often subtle or not present at birth. This likely is due to trans-placental passage of some maternal thyroid hormone, while many infants have some thyroid production of their own. Common symptoms include decreased activity and increased sleep, feeding difficulty, constipation, and prolonged jaundice. On examination, common signs include myxedematous facies, large fontanels, macroglossia, a distended abdomen with umbilical hernia, and hypotonia. CH is classified into permanent and transient forms, which in turn can be divided into primary, secondary, or peripheral etiologies. Thyroid dysgenesis accounts for 85% of permanent, primary CH, while inborn errors of thyroid hormone biosynthesis (dyshormonogeneses) account for 10-15% of cases. Secondary or central CH may occur with isolated TSH deficiency, but more commonly it is associated with congenital hypopitiutarism. Transient CH most commonly occurs in preterm infants born in areas of endemic iodine deficiency. In countries with newborn screening programs in place, infants with CH are diagnosed after detection by screening tests. The diagnosis should be confirmed by finding an elevated serum TSH and low T4 or free T4 level. Other diagnostic tests, such as thyroid radionuclide uptake and scan, thyroid sonography, or serum thyroglobulin determination may help pinpoint the underlying etiology, although treatment may be started without these tests. Levothyroxine is the treatment of choice; the recommended starting dose is 10 to 15 mcg/kg/day. The immediate goals of treatment are to rapidly raise the serum T4 above 130 nmol/L (10 ug/dL) and normalize serum TSH levels. Frequent laboratory monitoring in infancy is essential to ensure optimal neurocognitive outcome. Serum TSH and free T4 should be measured every 1-2 months in the first 6 months of life and every 3-4 months thereafter. In general, the prognosis of infants detected by screening and started on treatment early is excellent, with IQs similar to sibling or classmate controls. Studies show that a lower neurocognitive outcome may occur in those infants started at a later age (> 30 days of age), on lower l-thyroxine doses than currently recommended, and in those infants with more severe hypothyroidism

Integrated receiver architectures for board-to-board free-space optical interconnects

In many computer and server communications copper cables and wires are currently being used for data transmission and interconnects. However, due to significant shortcomings, such as long transmission time, high noise level, unstable electrical properties, and high power consumption for cooling, researchers are increasingly turning their research interests toward alternatives, such as fiber optic interconnects and free-space optical communication technologies. In this paper, we present design considerations for an integrated receiver for high-speed free-space line-of-sight optical interconnects for distortion-free data transmission in an environment with mechanical vibrations and air turbulences. The receiver consists of an array of high-speed photodiodes for data communication and an array of quadrant photodiodes for real-time beam tracking in order to compensate for the beam misalignment caused by vibrations in servers. Different configurations for spatially positioning the quadrant and data photodiodes are discussed for 4×4 and 9×9 multielement optical detector arrays. We also introduce a new beam tracking device, termed the strip quadrant photodiodes, in order to accurately track highly focused optical beams with very small beam diameter

Integrated receiver architectures for board-to-board free-space optical interconnects

In many computer and server communications copper cables and wires are currently being used for data transmission and interconnects. However, due to significant shortcomings, such as long transmission time, high noise level, unstable electrical properties, and high power consumption for cooling, researchers are increasingly turning their research interests toward alternatives, such as fiber optic interconnects and free-space optical communication technologies. In this paper, we present design considerations for an integrated receiver for high-speed free-space line-of-sight optical interconnects for distortion-free data transmission in an environment with mechanical vibrations and air turbulences. The receiver consists of an array of high-speed photodiodes for data communication and an array of quadrant photodiodes for real-time beam tracking in order to compensate for the beam misalignment caused by vibrations in servers. Different configurations for spatially positioning the quadrant and data photodiodes are discussed for 4×4 and 9×9 multielement optical detector arrays. We also introduce a new beam tracking device, termed the strip quadrant photodiodes, in order to accurately track highly focused optical beams with very small beam diameter