13 research outputs found
The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3
Efficient adjustable light couplers of integrated III–V nanowire emitters on silicon waveguides based on ring resonators
Sirtuin-1 regulates acinar to ductal metaplasia and supports cancer cell viability in pancreatic cancer
Pipette-based Method to Study Embryoid Body Formation Derived from Mouse and Human Pluripotent Stem Cells Partially Recapitulating Early Embryonic Development Under Simulated Microgravity Conditions
K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulation
People behind unhealthy obsession to healthy food: the personality profile of tendency to orthorexia nervosa
Indications and complications of inpatient parenteral nutrition prescribed to children in a large tertiary referral hospital
Do sirtuins promote mammalian longevity?: A Critical review on its relevance to the longevity effect induced by calorie restriction
Dynamics and functions of lipid droplets
Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They have a unique architecture consisting of a hydrophobic core of neutral lipids, which is enclosed by a phospholipid monolayer that is decorated by a specific set of proteins. Originating from the endoplasmic reticulum, lipid droplets can associate with most other cellular organelles through membrane contact sites. It is becoming apparent that these contacts between lipid droplets and other organelles are highly dynamic and coupled to the cycles of lipid droplet expansion and shrinkage. Importantly, lipid droplet biogenesis and degradation, as well as their interactions with other organelles, are tightly coupled to cellular metabolism and are critical to buffer the levels of toxic lipid species. Thus, lipid droplets facilitate the coordination and communication between different organelles and act as vital hubs of cellular metabolism