4,959 research outputs found
Demographic and outcome differences in ICU patients with proven invasive candidiasis, possible invasive candidiasis and probable candida colonization: analysis of the EPIC II study population
Trans-nasal cooling during CPR: a single-center experience
IntroductionTrans-nasal cooling started during cardiopulmonary resuscitation (CPR) has shown to improve the return to spontaneous circulation (ROSC) and survival rate in an experimental prolonged cardiac arrest model. A multicenter randomized trial (PRINCE) has also suggested an improved neurological outcome in patients receiving trans-nasal cooling during CPR in the prehospital setting when compared with those treated by conventional hypothermia on hospital arrival, provided a delay between collapse and CPR of less than 10 minutes. MethodsPatients with witnessed cardiac arrest and a downtime less than 20 minutes were randomized to prehospital intra-arrest cooling versus standard ACLS care. Trans-nasal cooling (RhinoChill, BeneChill Inc. CA, USA) was initiated using a mixture of volatile coolant fluid with oxygen delivered into the nasopharynx for rapid evaporative heat transfer. Cooling was continued during CPR and, for patients who achieved ROSC, until initiation of systemic cooling at hospital. Resuscitation was continued for at least 30 minutes. All patients were then cooled at the hospital. ResultsTwenty-four patients were included, but one in the treatment group was excluded from the per-protocol analysis because of DNR orders. Patients randomized to treatment group (n = 9) or standard care (n = 14) had similar demographics, initial rhythm, time from collapse to CPR and ALS arrival. Median time from collapse to cooling initiation was 19 minutes. In total, 6/9 (66%) treated and 6/14 (42%) control patients achieved ROSC. Three patients (33%) in the treatment group survived to hospital discharge with CPC 1 to 2, while only one (7%) of the control group patients had good neurological outcome. No serious adverse events occurred in treated patients. ConclusionsTrans-nasal cooling seems to be safe and feasible in a prehospital setting. These single-center data confirm that trans-nasal cooling may improve the ROSC rate as well as good neurological outcome if started in patients with a short delay between collapse and CPR.info:eu-repo/semantics/publishe
Impact of antifungal treatment in ICU patients with Candida colonization: analysis of the EPIC II study population
Real-World Inter-Observer Variability of the Sequential Organ Failure Assessment (SOFA) Score in Intensive Care Medicine: the Time Has come for an Update: Authors’ Reply
info:eu-repo/semantics/publishedVersio
Should red cell transfusion be individualized? Yes
SCOPUS: ed.jinfo:eu-repo/semantics/publishe
Corticosteroids reduce early troponin-T release after cardiac surgery with cardiopulmonary bypass in men
The ex vivo production of tumor necrosis factor-α (TNF-α) in men: relationship to cytokine balance during cardiopulmonary bypass
Limitations of the use of the Glasgow Coma Scale in intensive care patients with non-neurological primary disease: a search for alternatives
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