Sviluppo ed attuale impiego del RIS-PACS all'Ospedale del Cuore di Massa - Fondazione Toscana Gabriele Monasterio

L’informatizzazione e l’introduzione di nuove apparecchiature elettro-medicali si sta manifestando in maniera sempre più ampia nel settore sanitario, soprattutto nel campo della Diagnostica per Immagini che per tradizione è l’Unità Operativa in cui l’informatizzazione è più all’avanguardia e diffusa, in quanto si è avvertita l’esigenza di una gestione più efficace dei rapporti, sia a livello di gestione medico-legale sia per l’aumento delle richieste d’esami. La tecnologia ha portato ad una riduzione delle liste di attesa, allo snellimento del lavoro, ad un risparmio del materiale cartaceo e delle pellicole radiografiche, ed infine un ormai indispensabile mezzo di supporto per una giusta diagnosi, con relativi vantaggi in termini di salute e benessere dei pazienti. Tutto ciò non avviene solo grazie ai singoli prodotti tecnologici ma è dovuto anche ad una strategia di lavoro ben pianificata attraverso un “Workflow” cioè un flusso di lavoro completamente integrato che unisce l'utilizzo di software appropriati e l'acquisto di sistemi medicali o diagnostici complessi. Un aiuto importante è dato dal RIS, Radiology Information System, per la gestione dei dati alfanumerici e dall'iniziativa IHE, Integrating Healthcare Enterprise, modello a catena integrata che comincia dalla richiesta medica fino all'esecuzione dell'esame diagnostico e alla refertazione

How force perception changes in different refresh rate conditions

n this work we consider the role of different refresh rates of the force feedback physical engine for haptics environments, such as robotic surgery and virtual reality surgical training systems. Two experimental force feedback tasks are evaluated in a virtual environment. Experiment I is a passive contact task, where the hand-grip is held waiting for the force feedback perception given by the contact with virtual objects. Experiment II is an active contact task, where a tool is moved in a direction until the contact perception with a pliable object. Different stiffnesses and refresh rates are factorially manipulated. To evaluate differences in the two tasks, we account for latency time inside the wall, penetration depth, and maximum force exerted against the object surface. The overall result of these experiments shows an improved sensitivity in almost all variables considered with refresh rates of 500 and 1,000 Hz compared with a refresh rate of 250 Hz, but no improved sensitivity is showed among them

How force perception changes in different refresh rate conditions

n this work we consider the role of different refresh rates of the force feedback physical engine for haptics environments, such as robotic surgery and virtual reality surgical training systems. Two experimental force feedback tasks are evaluated in a virtual environment. Experiment I is a passive contact task, where the hand-grip is held waiting for the force feedback perception given by the contact with virtual objects. Experiment II is an active contact task, where a tool is moved in a direction until the contact perception with a pliable object. Different stiffnesses and refresh rates are factorially manipulated. To evaluate differences in the two tasks, we account for latency time inside the wall, penetration depth, and maximum force exerted against the object surface. The overall result of these experiments shows an improved sensitivity in almost all variables considered with refresh rates of 500 and 1,000 Hz compared with a refresh rate of 250 Hz, but no improved sensitivity is showed among them

Evolving homogeneous neuro-controllers for a group of heterogeneous robots: coordinated motion, cooperation, and acoustic communication

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Hyperlactatemia during cardiopulmonary bypass: determinants and impact on postoperative outcome

INTRODUCTION: Hyperlactatemia during cardiopulmonary bypass is relatively frequent and is associated with an increased postoperative morbidity. The aim of this study was to determine which perfusion-related factors may be responsible for hyperlactatemia, with specific respect to hemodilution and oxygen delivery, and to verify the clinical impact of hyperlactatemia during cardiopulmonary bypass in terms of postoperative morbidity and mortality rate. METHODS: Five hundred consecutive patients undergoing cardiac surgery with cardiopulmonary bypass were admitted to this prospective observational study. During cardiopulmonary bypass, serial arterial blood gas analyses with blood lactate and glucose determinations were obtained. Hyperlactatemia was defined as a peak arterial blood lactate concentration exceeding 3 mmol/l. Pre- and intraoperative factors were tested for independent association with the peak arterial lactate concentration and hyperlactatemia. The postoperative outcome of patients with or without hyperlactatemia was compared. RESULTS: Factors independently associated with hyperlactatemia were the preoperative serum creatinine value, the presence of active endocarditis, the cardiopulmonary bypass duration, the lowest oxygen delivery during cardiopulmonary bypass, and the peak blood glucose level. Once corrected for other explanatory variables, hyperlactatemia during cardiopulmonary bypass remained significantly associated with an increased morbidity, related mainly to a postoperative low cardiac output syndrome, but not to mortality. CONCLUSION: Hyperlactatemia during cardiopulmonary bypass appears to be related mainly to a condition of insufficient oxygen delivery (type A hyperlactatemia). During cardiopulmonary bypass, a careful coupling of pump flow and arterial oxygen content therefore seems mandatory to guarantee a sufficient oxygen supply to the peripheral tissues

Long-term mortality in a population exposed to inorganic selenium through drinking water.

Long-term mortality in a population exposed to inorganic selenium through drinking water

Effect of different functionalized carbon nanostructures as fillers on the physical properties of biocompatible poly( l -lactic acid) composites

Composites of carbon nanostructures (CNSs) and biocompatible polymers are promising materials for a series of advanced technological applications, ranging from biomedicine and bioelectronics to smart packaging and soft robotics. In this work, we present three types of organic-functionalized CNSs, namely p-methoxyphenyl functionalized multi-walled carbon nanotubes, carbon nanohorns and reduced graphene oxide, used as nanofillers for the preparation of homogeneous and well-dispersed composites of poly(L-lactic acid), a biocompatible and biodegradable FDA-approved polymer. A thorough characterization of the composites is given in terms of calorimetric response, electrical and mechanical properties. Significant differences are observed among the different types of CNS nanofillers, underlying the key role played by the nanoscale shape and distribution of the components in driving the macroscopic behavior of the composite material. Surface properties are probed through advanced atomic force microscopy techniques, on both flat substrates (films) and confined systems (nanofibers). All these composites proved to be biocompatible and to support as scaffolds the proliferation of human neuronal precursor cell line SH-SY5Y, opening the route to a future comparative analysis on their ability to boost neuronal differentiation

Impact of Insulin Therapies on Cancer Incidence in Type 1 and Type 2 Diabetes: A Population-Based Cohort Study in Reggio Emilia, Italy

Simple Summary The aim of this population-based study was to assess the impact of insulin treatment on cancer incidence in subjects with type 1 or type 2 diabetes in Italy. We found that insulin use was associated with a 20% excess for all sites cancer incidence among people with type 2 diabetes, while people with type 1 diabetes did not show any excess. Liver, pancreatic, bladder, and neuroendocrine cancers seem to be the sites with strongest association. Objective: To assess the effect of insulin on cancer incidence in type 1 (T1DM) and type 2 diabetes (T2DM). Methods: The cohort included all 401,172 resident population aged 20-84 in December 2009 and still alive on December 2011, classified for DM status. Drug exposure was assessed for 2009-2011 and follow up was conducted from 2012 to 2016 through the cancer registry. Incidence rate ratios (IRRs) were computed for all sites and for the most frequent cancer sites. Results: among residents, 21,190 people had diabetes, 2282 of whom were taking insulin; 1689 cancers occurred, 180 among insulin users. The risk for all site was slightly higher in people with T2DM compared to people without DM (IRR 1.21, 95% CI 1.14-1.27), with no excess for T1DM (IRR 0.73, 95% CI 0.45-1.19). The excess in T2DM remained when comparing with diet-only treatment. In T2DM, excess incidence was observed for liver and pancreas and for NETs: 1.76 (95% CI 1.44-2.17) and 1.37 (95% CI 0.99-1.73), respectively. For bladder, there was an excess both in T1DM (IRR 3.00, 95% CI 1.12, 8.02) and in T2DM (IRR1.27, 95% CI 1.07-1.50). Conclusions: Insulin was associated with a 20% increase in cancer incidence. The risk was higher for liver, pancreatic, bladder and neuroendocrine tumours

Experimental and Modelling Analysis of the Hyperthermia Properties of Iron Oxide Nanocubes

open10sìThe ability of magnetic nanoparticles (MNPs) to transform electromagnetic energy into heat is widely exploited in well-known thermal cancer therapies, such as magnetic hyperthermia, which proves useful in enhancing the radio- and chemo-sensitivity of human tumor cells. Since the heat release is ruled by the complex magnetic behavior of MNPs, a careful investigation is needed to understand the role of their intrinsic (composition, size and shape) and collective (aggregation state) properties. Here, the influence of geometrical parameters and aggregation on the specific loss power (SLP) is analyzed through in-depth structural, morphological, magnetic and thermometric characterizations supported by micromagnetic and heat transfer simulations. To this aim, different samples of cubic Fe3O4 NPs with an average size between 15 nm and 160 nm are prepared via hydrothermal route. For the analyzed samples, the magnetic behavior and heating properties result to be basically determined by the magnetic single- or multi-domain configuration and by the competition between magnetocrystalline and shape anisotropies. This is clarified by micromagnetic simulations, which enable us to also elucidate the role of magnetostatic interactions associated with locally strong aggregation.openhttps://zenodo.org/record/5040394#.YhVWyejMKUkFerrero, R; Barrera, G; Celegato, F; Vicentini, M; Sozeri, H; Yildiz, N; Dincer, CA; Coisson, M; Manzin, A; Tiberto, PFerrero, R; Barrera, G; Celegato, F; Vicentini, M; Sozeri, H; Yildiz, N; Dincer, Ca; Coisson, M; Manzin, A; Tiberto,