17 research outputs found
Effect of hypoxia on the activity and binding of glycolytic and associated enzymes in sea scorpion tissues
Full text linkMild Mitochondrial Uncoupling and Calorie Restriction Increase Fasting eNOS, Akt and Mitochondrial Biogenesis
Get PDFEnhanced mitochondrial biogenesis promoted by eNOS activation is believed to play a central role in the beneficial effects of calorie restriction (CR). Since treatment of mice with dinitrophenol (DNP) promotes health and lifespan benefits similar to those observed in CR, we hypothesized that it could also impact biogenesis. We found that DNP and CR increase citrate synthase activity, PGC-1α, cytochrome c oxidase and mitofusin-2 expression, as well as fasting plasma levels of NO• products. In addition, eNOS and Akt phosphorylation in skeletal muscle and visceral adipose tissue was activated in fasting CR and DNP animals. Overall, our results indicate that systemic mild uncoupling activates eNOS and Akt-dependent pathways leading to mitochondrial biogenesis
Selective targeting of myeloid-derived suppressor cells in cancer patients through AFP-binding receptors
No full textHematology and serum biochemistry of European mouflon (Ovis orientalis musimon) in Croatia
No full textCalcium-independent uncoupling activity of palmitic acid in liver mitochondria is regulated by the ion fluxes causing the interconversion of Δψ and ΔpH across the inner membrane
No full textEfficacy of a web- and text messaging-based intervention to reduce problem drinking in young people: study protocol of a cluster-randomised controlled trial
No full textHerbicide monuron mediated alterations in carbon and nitrogen fixation in the cyanobacterium Nostoc muscorum Meg 1
No full textPossible Medical Applications of Membrane Bioenergetics: Mitochondria-Targeted Antioxidants as Geroprotectors
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