181 research outputs found
An \emph{ab initio} method for locating characteristic potential energy minima of liquids
It is possible in principle to probe the many--atom potential surface using
density functional theory (DFT). This will allow us to apply DFT to the
Hamiltonian formulation of atomic motion in monatomic liquids [\textit{Phys.
Rev. E} {\bf 56}, 4179 (1997)]. For a monatomic system, analysis of the
potential surface is facilitated by the random and symmetric classification of
potential energy valleys. Since the random valleys are numerically dominant and
uniform in their macroscopic potential properties, only a few quenches are
necessary to establish these properties. Here we describe an efficient
technique for doing this. Quenches are done from easily generated "stochastic"
configurations, in which the nuclei are distributed uniformly within a
constraint limiting the closeness of approach. For metallic Na with atomic pair
potential interactions, it is shown that quenches from stochastic
configurations and quenches from equilibrium liquid Molecular Dynamics (MD)
configurations produce statistically identical distributions of the structural
potential energy. Again for metallic Na, it is shown that DFT quenches from
stochastic configurations provide the parameters which calibrate the
Hamiltonian. A statistical mechanical analysis shows how the underlying
potential properties can be extracted from the distributions found in quenches
from stochastic configurations
Cognitive impairment in coeliac disease with respect to disease duration and gluten-free diet adherence : a pilot study
Cognitive deficit has been reported in coeliac disease (CD), but previous reports often study heterogenous samples of patients at multiple stages of the disease, or lack control data. Healthy controls (N = 21), newly diagnosed CD patients (NCD; N = 19) and established CD patients (ECD; N = 35) were recruited from a specialist UK centre. Participants underwent a cognitive test battery that established seven overall domain scores. The SF-36 was administered as a quality of life (QoL) measure. Controlling for age, data were compared in between-group ANCOVAs with Tukey’s post-hoc test. Any significant outcome was compared in the ECD group only, between patients who were gluten-free diet adherent vs. non-adherent (defined via Biagi score and serology results). NCD and ECD groups underperformed relative to controls, by comparable degrees, in visual (overall model: p < 0.001) and verbal (p = 0.046) memory. The ECD group only underperformed in visuoconstructive abilities (p = 0.050). Regarding QoL, the NCD group reported lower vitality (p = 0.030), while the ECD group reported more bodily pain (p = 0.009). Comparisons based on dietary adherence were non-significant. These findings confirm cognitive deficit in CD. Dysfunction appears established at the point of diagnosis, after which it (predominantly) stabilises. While a beneficial effect of dietary treatment is therefore implied, future research is needed to establish to what extent any further decline is due to gluten exposure
Liquid state properties from first principles DFT calculations: Static properties
In order to test the Vibration-Transit (V-T) theory of liquid dynamics, ab
initio density functional theory (DFT) calculations of thermodynamic properties
of Na and Cu are performed and compared with experimental data. The
calculations are done for the crystal at T = 0 and T_m, and for the liquid at
T_m. The key theoretical quantities for crystal and liquid are the structural
potential and the dynamical matrix, both as function of volume. The theoretical
equations are presented, as well as details of the DFT computations. The
properties compared with experiment are the equilibrium volume, the isothermal
bulk modulus, the internal energy and the entropy. The agreement of theory with
experiment is uniformly good. Our primary conclusion is that the application of
DFT to V-T theory is feasible, and the resulting liquid calculations achieve
the same level of accuracy as does ab initio lattice dynamics for crystals.
Moreover, given the well established reliability of DFT, the present results
provide a significant confirmation of V-T theory itself.Comment: 9 pages, 3 figures, 5 tables, edited to more closely match published
versio
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Disposition of nuclear waste using subcritical accelerator-driven systems
Spent fuel from nuclear power plants contains large quantities of Pu, other actinides, and fission products (FP). This creates challenges for permanent disposal because of the long half-lives of some isotopes and the potential for diversion of the fissile material. Two issues of concern for the US repository concept are: (1) long-term radiological risk peaking tens-of-thousands of years in the future; and (2) short-term thermal loading (decay heat) that limits capacity. An accelerator-driven neutron source can destroy actinides through fission, and can convert long-lived fission products to shorter-lived or stable isotopes. Studies over the past decade have established that accelerator transmutation of waste (ATW) can have a major beneficial impact on the nuclear waste problem. Specifically, the ATW concept the authors are evaluating: (1) destroys over 99.9% of the actinides; (2) destroys over 99.9% of the Tc and I; (3) separates Sr-90 and Cs-137; (4) separates uranium from the spent fuel; (5) produces electric power
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Disposition of nuclear waste using subcritical accelerator-driven systems
Studies have shown that the repository long-term radiological risk is from the long-lived transuranics and the fission products Tc-99 and I-129, thermal loading concerns arise mainly form the short-lived fission products Sr-90 and Cs-137. In relation to the disposition of nuclear waste, ATW is expected to accomplish the following: (1) destroy over 99.9% of the actinides; (2) destroy over 99.9% of the Tc and I; (3) separate Sr and Cs (short half-life isotopes); (4) separate uranium; (5) produce electricity. In the ATW concept, spent fuel would be shipped to a ATW site where the plutonium, other transuranics and selected long-lived fission products would be destroyed by fission or transmutation in their only pass through the facility. This approach contrasts with the present-day reprocessing practices in Europe and Japan, during which high purity plutonium is produced and used in the fabrication of fresh mixed-oxide fuel (MOX) that is shipped off-site for use in light water reactors
Investigating Dementia via a multicompartmental poroelastic model of parenchymal tissue
In this paper, a workflow within the VPH-DARE@IT Clinical Research Platform is presented. This
is used to model the biomechanical behaviour of perfused brain tissue. This workflow features a 3D
multicompartmental poroelastic framework, patient-specific brain anatomy representations and
continuous waveforms of internal carotid and vertebral arteries, which are used as a means of
personalizing the boundary conditions that feed the arterial compartment of the in-house
poroelastic solver. Results are shown comparing CSF/ISF clearance and accumulation in two males
of similar age, both are non-smokers, however one is more active and is diagnosed with MCI and
experiences less sleep
Subject-specific multiporoelastic model for exploring the risk factors associated with the early stages of Alzheimer's disease
There is emerging evidence suggesting that Alzheimer’s disease is a vascular disorder, caused by impaired cerebral perfusion, which may be promoted by cardiovascular risk factors that are strongly influenced by lifestyle. In order to develop an understanding of the exact nature of such a hypothesis, a biomechanical understanding of the influence of lifestyle factors is pursued. An extended poroelastic model of perfused parenchymal tissue coupled with separate workflows concerning subject-specific meshes, permeability tensor maps and cerebral blood flow (CBF) variability is utilised. The subject-specific datasets used in the modelling of this paper were collected as part of prospective data collection. Two cases were simulated involving male, non-smokers (control and MCI case) during two states of activity (high and low). Results showed a marginally reduced clearance of CSF/ISF, elevated parenchymal tissue displacement and CSF/ISF accumulation and drainage in the MCI case. Peak perfusion remained at 8 mm/s between the two cases
V-T Theory of Self Dynamic Response in a Monatomic Liquid
A new theoretical model for self dynamic response is developed using
Vibration-Transit (V-T) theory, and is applied to liquid sodium at all
wavevectors q from the hydrodynamic regime to the free particle limit. In this
theory the zeroth-order Hamiltonian describes the vibrational motion in a
single random valley harmonically extended to infinity. This Hamiltonian is
tractable, is evaluated a priori for monatomic liquids, and the same
Hamiltonian (the same set of eigenvalues and eigenvectors) is used for
equilibrium and nonequlibrium theory. Here, for the self intermediate
scattering function Fself(q,t) we find the vibrational contribution is in near
perfect agreement with molecular dynamics (MD) through short and intermediate
times, at all q. This is direct confirmation that normal mode vibrational
correlations are present in the motion of the liquid state. The primary transit
effect is diffusive motion of the vibrational equilibrium positions, as the
liquid transits rapidly among random valleys. This motion is modeled as a
standard random walk, and the resulting theoretical Fself(q,t) is in excellent
agreement with MD results at all q and t. In the limit for q to infinity, the
theory automatically exhibits the correct approach to the free-particle limit.
Also in the limit for q to zero, the hydrodynamic limit emerges as well. In
contrast to the benchmark theories of generalized hydrodynamics and mode
coupling, the present theory is near a priori, while achieving modestly better
accuracy. Therefore, in our view, it constitutes an improvement over the
traditional theories.Comment: 16 pages, 11 figures, Journal Paper. Following referee's comments,
Section IID has been completely rewritten and a new Section IIE has been
adde
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