23 research outputs found
Ash2 acts as an Ecdysone Receptor coactivator by stabilizing the histone methyltransferase Trr.
Get PDFThe molting hormone ecdysone triggers chromatin changes via histone modifica- tions that are important for gene regulation. On hormone activation, the ecdysone receptor (EcR) binds to the SET domain-containing histone H3 methyltransferase trithorax-related protein (Trr). Methylation of histone H3 at lysine 4 (H3K4me), which is associated with tran- scriptional activation, requires several cofactors, including Ash2. We find that ash2 mutants have severe defects in pupariation and metamorphosis due to a lack of activation of ecdy- sone-responsive genes. This transcriptional defect is caused by the absence of the H3K4me3 marks set by Trr in these genes. We present evidence that Ash2 interacts with Trr and is re- quired for its stabilization. Thus we propose that Ash2 functions together with Trr as an ecdysone receptor coactivator
Auditory experience-dependent cortical circuit shaping for memory formation in bird song learning
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Localised intraspecific variation in the swimming phenotype of a coral reef fish across different wave exposures
No full textPreliminary Observations of Population Genetics and Relatedness of the Broadnose Sevengill Shark, Notorynchus cepedianus, in Two Northeast Pacific Estuaries
No full textTargeting interferon response genes sensitizes aromatase inhibitor resistant breast cancer cells to estrogen-induced cell death
No full textCyclin dependent kinase-9 mediated transcriptional de-regulation of cMYC as a critical determinant of endocrine-therapy resistance in breast cancers
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Anatomically Discrete Sex Differences in Neuroplasticity in Zebra Finches as Reflected by Perineuronal Nets
No full textGenetic structure in lagoons: the effects of habitat discontinuity and low dispersal ability on populations of Atherina boyeri
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