Diels–Alder cycloadditions of strained azacyclic allenes

For over a century, the structures and reactivities of strained organic compounds have captivated the chemical community. Whereas triple-bond-containing strained intermediates have been well studied, cyclic allenes have received far less attention. Additionally, studies of cyclic allenes that bear heteroatoms in the ring are scarce. We report an experimental and computational study of azacyclic allenes, which features syntheses of stable allene precursors, the mild generation and Diels-Alder trapping of the desired cyclic allenes, and explanations of the observed regio- and diastereoselectivities. Furthermore, we show that stereochemical information can be transferred from an enantioenriched silyl triflate starting material to a Diels-Alder cycloadduct by way of a stereochemically defined azacyclic allene intermediate. These studies demonstrate that heteroatom-containing cyclic allenes, despite previously being overlooked as valuable synthetic intermediates, may be harnessed for the construction of complex molecular scaffolds bearing multiple stereogenic centres

Aetiology diagnosis and treatment of posterior cross-bites in the primary dentition

Children who present with a posterior cross-bite in the primary dentition may be predisposed to long-term detrimental consequences if the condition is left untreated. Controversy exists in the literature as to the most appropriate time to treat this condition. Objectives. The aim of this review is to evaluate the need for correcting posterior cross-bites in the primary dentition based on the current understanding of the aetiology, likelihood of self-correction, and consequences of various forms of this malocclusion persisting into the mixed and permanent dentitions. A review of the reported treatment options for management of this condition is also presented. Methods. Literature pertaining to the epidemiology and management of posterior cross-bites in the primary dentition are reviewed. Conclusion. Posterior cross-bites in the primary dentition are relatively common and their causes are numerous. Because a significant proportion of posterior cross-bites self-correct beyond the primary dentition, routine correction in the primary dentition phase cannot be advocated. A unilateral posterior cross-bite as a result of a functional displacement of the mandible is one of the few malocclusions which should be considered for correction in the primary dentition. Further research is needed in the management of this condition