19 research outputs found
Antarctica challenges the new horizons in predictive, preventive, personalized medicine: preliminary results and attractive hypotheses for multi-disciplinary prospective studies in the Ukrainian “Akademik Vernadsky” station
Predictive diagnosis of endometrial hyperplasia and personalized therapeutic strategy in women of fertile age
Velocity of propagation of temperature anomalies in the tropical zone of the Indian Ocean
The development and investigation of a strongly non-equilibrium model of heat transfer in fluid with allowance for the spatial and temporal non-locality and energy dissipation
Involvement of xanthine oxidase and hypoxia-inducible factor 1 in Toll-like receptor 7/8-mediated activation of caspase 1 and interleukin-1?
Inflammatory reactions to ssRNA viruses are induced by the endosomal Toll-like receptors (TLRs) 7 and 8. TLR7/8-mediated inflammatory reaction results in activation of the Nalp3 inflammasome via an unknown mechanism. Here we report for the first time that TLR7/8 mediate activation of xanthine oxidase (XOD) in an HIF-1?-dependent manner. XOD produces uric acid and reactive oxygen species, which could activate Nalp3 and therefore induce activation of caspase 1, known to convert inactive pro-IL-1? into active IL-1?. Specific inhibition of the XOD activity attenuates TLR7/8-mediated activation of caspase 1 and IL-1? release. These results were obtained using human THP-1 myeloid macrophages. The findings were verified by conducting in vivo experiments on mice