19 research outputs found
Antarctica challenges the new horizons in predictive, preventive, personalized medicine: preliminary results and attractive hypotheses for multi-disciplinary prospective studies in the Ukrainian “Akademik Vernadsky” station
Full text linkPredictive diagnosis of endometrial hyperplasia and personalized therapeutic strategy in women of fertile age
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Velocity of propagation of temperature anomalies in the tropical zone of the Indian Ocean
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The development and investigation of a strongly non-equilibrium model of heat transfer in fluid with allowance for the spatial and temporal non-locality and energy dissipation
No full textInvolvement of xanthine oxidase and hypoxia-inducible factor 1 in Toll-like receptor 7/8-mediated activation of caspase 1 and interleukin-1?
No full textInflammatory reactions to ssRNA viruses are induced by the endosomal Toll-like receptors (TLRs) 7 and 8. TLR7/8-mediated inflammatory reaction results in activation of the Nalp3 inflammasome via an unknown mechanism. Here we report for the first time that TLR7/8 mediate activation of xanthine oxidase (XOD) in an HIF-1?-dependent manner. XOD produces uric acid and reactive oxygen species, which could activate Nalp3 and therefore induce activation of caspase 1, known to convert inactive pro-IL-1? into active IL-1?. Specific inhibition of the XOD activity attenuates TLR7/8-mediated activation of caspase 1 and IL-1? release. These results were obtained using human THP-1 myeloid macrophages. The findings were verified by conducting in vivo experiments on mice
Entropy of flux relaxation and variational theory of simultaneous energy and mass transport governed by non-Onsager phenomenological equations
No full textAssessing the impact of various wind forcing on INCOIS-GODAS simulated ocean currents in the equatorial Indian Ocean
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