111 research outputs found
Brezin-Gross-Witten model as "pure gauge" limit of Selberg integrals
The AGT relation identifies the Nekrasov functions for various N=2 SUSY gauge
theories with the 2d conformal blocks, which possess explicit Dotsenko-Fateev
matrix model (beta-ensemble) representations the latter being polylinear
combinations of Selberg integrals. The "pure gauge" limit of these matrix
models is, however, a non-trivial multiscaling large-N limit, which requires a
separate investigation. We show that in this pure gauge limit the Selberg
integrals turn into averages in a Brezin-Gross-Witten (BGW) model. Thus, the
Nekrasov function for pure SU(2) theory acquires a form very much reminiscent
of the AMM decomposition formula for some model X into a pair of the BGW
models. At the same time, X, which still has to be found, is the pure gauge
limit of the elliptic Selberg integral. Presumably, it is again a BGW model,
only in the Dijkgraaf-Vafa double cut phase.Comment: 21 page
The matrix model version of AGT conjecture and CIV-DV prepotential
Recently exact formulas were provided for partition function of conformal
(multi-Penner) beta-ensemble in the Dijkgraaf-Vafa phase, which, if interpreted
as Dotsenko-Fateev correlator of screenings and analytically continued in the
number of screening insertions, represents generic Virasoro conformal blocks.
Actually these formulas describe the lowest terms of the q_a-expansion, where
q_a parameterize the shape of the Penner potential, and are exact in the
filling numbers N_a. At the same time, the older theory of CIV-DV prepotential,
straightforwardly extended to arbitrary beta and to non-polynomial potentials,
provides an alternative expansion: in powers of N_a and exact in q_a. We check
that the two expansions coincide in the overlapping region, i.e. for the lowest
terms of expansions in both q_a and N_a. This coincidence is somewhat
non-trivial, since the two methods use different integration contours:
integrals in one case are of the B-function (Euler-Selberg) type, while in the
other case they are Gaussian integrals.Comment: 27 pages, 1 figur
Matrix Model Conjecture for Exact BS Periods and Nekrasov Functions
We give a concise summary of the impressive recent development unifying a
number of different fundamental subjects. The quiver Nekrasov functions
(generalized hypergeometric series) form a full basis for all conformal blocks
of the Virasoro algebra and are sufficient to provide the same for some
(special) conformal blocks of W-algebras. They can be described in terms of
Seiberg-Witten theory, with the SW differential given by the 1-point resolvent
in the DV phase of the quiver (discrete or conformal) matrix model
(\beta-ensemble), dS = ydz + O(\epsilon^2) = \sum_p \epsilon^{2p}
\rho_\beta^{(p|1)}(z), where \epsilon and \beta are related to the LNS
parameters \epsilon_1 and \epsilon_2. This provides explicit formulas for
conformal blocks in terms of analytically continued contour integrals and
resolves the old puzzle of the free-field description of generic conformal
blocks through the Dotsenko-Fateev integrals. Most important, this completes
the GKMMM description of SW theory in terms of integrability theory with the
help of exact BS integrals, and provides an extended manifestation of the basic
principle which states that the effective actions are the tau-functions of
integrable hierarchies.Comment: 14 page
Boundary operators in minimal Liouville gravity and matrix models
We interpret the matrix boundaries of the one matrix model (1MM) recently
constructed by two of the authors as an outcome of a relation among FZZT
branes. In the double scaling limit, the 1MM is described by the (2,2p+1)
minimal Liouville gravity. These matrix operators are shown to create a
boundary with matter boundary conditions given by the Cardy states. We also
demonstrate a recursion relation among the matrix disc correlator with two
different boundaries. This construction is then extended to the two matrix
model and the disc correlator with two boundaries is compared with the
Liouville boundary two point functions. In addition, the realization within the
matrix model of several symmetries among FZZT branes is discussed.Comment: 26 page
Observation of a J^PC = 1-+ exotic resonance in diffractive dissociation of 190 GeV/c pi- into pi- pi- pi+
The COMPASS experiment at the CERN SPS has studied the diffractive
dissociation of negative pions into the pi- pi- pi+ final state using a 190
GeV/c pion beam hitting a lead target. A partial wave analysis has been
performed on a sample of 420000 events taken at values of the squared
4-momentum transfer t' between 0.1 and 1 GeV^2/c^2. The well-known resonances
a1(1260), a2(1320), and pi2(1670) are clearly observed. In addition, the data
show a significant natural parity exchange production of a resonance with
spin-exotic quantum numbers J^PC = 1-+ at 1.66 GeV/c^2 decaying to rho pi. The
resonant nature of this wave is evident from the mass-dependent phase
differences to the J^PC = 2-+ and 1++ waves. From a mass-dependent fit a
resonance mass of 1660 +- 10+0-64 MeV/c^2 and a width of 269+-21+42-64 MeV/c^2
is deduced.Comment: 7 page, 3 figures; version 2 gives some more details, data unchanged;
version 3 updated authors, text shortened, data unchange
Depletion of somatic mutations in splicing-associated sequences in cancer genomes
Abstract Background An important goal of cancer genomics is to identify systematically cancer-causing mutations. A common approach is to identify sites with high ratios of non-synonymous to synonymous mutations; however, if synonymous mutations are under purifying selection, this methodology leads to identification of false-positive mutations. Here, using synonymous somatic mutations (SSMs) identified in over 4000 tumours across 15 different cancer types, we sought to test this assumption by focusing on coding regions required for splicing. Results Exon flanks, which are enriched for sequences required for splicing fidelity, have ~ 17% lower SSM density compared to exonic cores, even after excluding canonical splice sites. While it is impossible to eliminate a mutation bias of unknown cause, multiple lines of evidence support a purifying selection model above a mutational bias explanation. The flank/core difference is not explained by skewed nucleotide content, replication timing, nucleosome occupancy or deficiency in mismatch repair. The depletion is not seen in tumour suppressors, consistent with their role in positive tumour selection, but is otherwise observed in cancer-associated and non-cancer genes, both essential and non-essential. Consistent with a role in splicing modulation, exonic splice enhancers have a lower SSM density before and after controlling for nucleotide composition; moreover, flanks at the 5’ end of the exons have significantly lower SSM density than at the 3’ end. Conclusions These results suggest that the observable mutational spectrum of cancer genomes is not simply a product of various mutational processes and positive selection, but might also be shaped by negative selection
A novel method to compare protein structures using local descriptors
<p>Abstract</p> <p>Background</p> <p>Protein structure comparison is one of the most widely performed tasks in bioinformatics. However, currently used methods have problems with the so-called "difficult similarities", including considerable shifts and distortions of structure, sequential swaps and circular permutations. There is a demand for efficient and automated systems capable of overcoming these difficulties, which may lead to the discovery of previously unknown structural relationships.</p> <p>Results</p> <p>We present a novel method for protein structure comparison based on the formalism of local descriptors of protein structure - DEscriptor Defined Alignment (DEDAL). Local similarities identified by pairs of similar descriptors are extended into global structural alignments. We demonstrate the method's capability by aligning structures in difficult benchmark sets: curated alignments in the SISYPHUS database, as well as SISY and RIPC sets, including non-sequential and non-rigid-body alignments. On the most difficult RIPC set of sequence alignment pairs the method achieves an accuracy of 77% (the second best method tested achieves 60% accuracy).</p> <p>Conclusions</p> <p>DEDAL is fast enough to be used in whole proteome applications, and by lowering the threshold of detectable structure similarity it may shed additional light on molecular evolution processes. It is well suited to improving automatic classification of structure domains, helping analyze protein fold space, or to improving protein classification schemes. DEDAL is available online at <url>http://bioexploratorium.pl/EP/DEDAL</url>.</p
M5-branes, toric diagrams and gauge theory duality
In this article we explore the duality between the low energy effective
theory of five-dimensional N=1 SU(N)^{M-1} and SU(M)^{N-1} linear quiver gauge
theories compactified on S^1. The theories we study are the five-dimensional
uplifts of four-dimensional superconformal linear quivers. We study this
duality by comparing the Seiberg-Witten curves and the Nekrasov partition
functions of the two dual theories. The Seiberg-Witten curves are obtained by
minimizing the worldvolume of an M5-brane with nontrivial geometry. Nekrasov
partition functions are computed using topological string theory. The result of
our study is a map between the gauge theory parameters, i.e., Coulomb moduli,
masses and UV coupling constants, of the two dual theories. Apart from the
obvious physical interest, this duality also leads to compelling mathematical
identities. Through the AGTW conjecture these five-dimentional gauge theories
are related to q-deformed Liouville and Toda SCFTs in two-dimensions. The
duality we study implies the relations between Liouville and Toda correlation
functions through the map we derive.Comment: 58 pages, 17 figures; v2: minor corrections, references adde
- …