19 research outputs found
Microwave assisted synthesis of novel bis-flavone dimers as new anticancer agents
Get PDFIn this study we describe a microwave based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bis-flavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 µM. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures
Crosslinking of viral nanoparticles with “clickable” fluorescent crosslinkers at the interface
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ПРИМЕНЕНИЕ СИСТЕМЫ ОТРИЦАТЕЛЬНОГО ДАВЛЕНИЯ(VAC ТЕРАПИИ) В ЛЕЧЕНИИ ДЕФЕКТА ПИЩЕВОДА У РЕБЕНКА С УДВОЕНИЕМ ПИЩЕВОДА (КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕ)
No full textDetection of encrypted executable files based on entropy analysis to determine the randomness measure of byte sequences
No full textSynthesis, characterization and catalytic properties of a copper-containing polyoxovanadate nanocluster in azide–alkyne cycloaddition
No full textOn some Rarecostites (Parkinsoniidae, Ammonoidea) from the Upper Bajocian Parkinsoni zone of the Northern Caucasus
No full textSynthesis of Unsymmetrical Polymethine Cyanine Fluorescent Dyes for Nucleic Acid Analysis by Real-Time PCR
No full textNovel Cyanoarylporphyrazines with Triazole Groups at the Macrocycle Periphery as Potential Sensibilizers of Photodynamic Therapy and Optical Probes of Intracellular Viscosity
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