Создание лаборатории "Наносистемы в машиностроении"

In clause importance of normalization of a roughness of a surface is analyzed and comparison of results of definition micro-and nanoroughnesses is made

Получение математической модели качества поверхности детали типа оболочки вращения из кварцевой конструкционной керамики

The results of the investigation into the grinding of the double curvature structural quartz ceramic shell of revolution are given. The planning matrix has been developed to carry out the experiment. The equation of surface roughness regression has been derived. The response surfaces have been formed. The most significant factors are defined, and recommendations on how to determine the machining conditions are given.Приведены результаты исследования по шлифованию оболочки вращения двойной кривизны из кварцевой конструкционной керамики. Построена матрица планирования для проведения эксперимента. Получено уравнение регрессии шероховатости поверхности. Построены поверхности отклика. Определены наиболее значимые факторы и приведены рекомендации по определению режимов механической обработки

Исследование твердости и шероховатости образцов из кварцевой керамики в зависимости от дефектности поверхности

Studies on the evaluation of quartz glass ceramics NIASIT (SiO2) hardness with the use of electronic microhardness tester have been conducted. 3D patterns of specimen surface topography and profiles at the specified cross-sections are given. The dependence of quartz ceramics hardness on the burning temperature and porosity is shown.Проведены исследования по определению твердости кварцевой стеклокерамики НИАСИТ (SiO2) при помощи электронного микротвердомера. Приведены трехмерные картины топографии поверхности образцов и профилей по указанным сечениям. Показана зависимость твердости кварцевой керамики от температуры обжига и пористости

Binding adaptation of GS 441524 diversifies macro domains and downregulate SARS CoV 2 de MARylation capacity

Viral infection in cells triggers a cascade of molecular defense mechanisms to maintain host cell homoeostasis. One of these mechanisms is ADP ribosylation, a fundamental post translational modification PTM characterized by the addition of ADP ribose ADPr on substrates. Poly ADP ribose polymerases PARPs are implicated in this process and they perform ADP ribosylation on host and pathogen proteins. Some viral families contain structural motifs that can reverse this PTM. These motifs known as macro domains MDs are evolutionarily conserved protein domains found in all kingdoms of life. They are divided in different classes with the viral belonging to Macro D type class because of their properties to recognize and revert the ADP ribosylation. Viral MDs are potential pharmaceutical targets, capable to counteract host immune response. Sequence and structural homology between viral and human MDs are an impediment for the development of new active compounds against their function. Remdesivir, is a drug administrated in viral infections inhibiting viral replication through RNA dependent RNA polymerase RdRp . Herein, GS 441524, the active metabolite of the remdesivir, is tested as a hydrolase inhibitor for several viral MDs and for its binding to human homologs found in PARPs. This study presents biochemical and biophysical studies, which indicate that GS 441524 selectively modifies SARS CoV 2 MD de MARylation activity, while it does not interact with hPARP14 MD2 and hPARP15 MD2. The structural investigation of MD GS 441524 complexes, using solution NMR and X ray crystallography, discloses the impact of certain amino acids in ADPr binding cavity suggesting that F360 and its adjacent residues tune the selective binding of the inhibitor to SARS CoV 2 M

Experimental and analytical research on relationship between tool life and vibration in cutting process

New identification and evaluation techniques for machining systems lead to an increase in the efficiency of a production system. This paper presents relationship between tool life, design features, fatigue strength and parameters of vibrations. To cope with this objective, vibration influence on tool wear is assessed, which considers the phase shift of vibration in different coordinates and forces on rake and rear faces of the tool. Tool life is predicted based on fatigue strength of tool material and parameters of tool vibrations. Static and dynamic characteristics of cutting tools during different machining conditions are analyzed using different cutting tools. Test results of cutting tools with different clamping types during static, dynamic and cutting processes, together with the simulation results suggest a relationship between the characteristics of the tool, the elastic system vibrations and tool life. © 2018 Politechnika Wrocławsk

Experimental and analytical research on relationship between tool life and vibration in cutting process

New identification and evaluation techniques for machining systems lead to an increase in the efficiency of a production system. This paper presents relationship between tool life, design features, fatigue strength and parameters of vibrations. To cope with this objective, vibration influence on tool wear is assessed, which considers the phase shift of vibration in different coordinates and forces on rake and rear faces of the tool. Tool life is predicted based on fatigue strength of tool material and parameters of tool vibrations. Static and dynamic characteristics of cutting tools during different machining conditions are analyzed using different cutting tools. Test results of cutting tools with different clamping types during static, dynamic and cutting processes, together with the simulation results suggest a relationship between the characteristics of the tool, the elastic system vibrations and tool life. © 2018 Politechnika Wrocławsk

Sputtering of Silicon Surface during Low-Energy High-Dose Implantation with Silver Ions

© 2020, Pleiades Publishing, Ltd. Abstract: We report on the results of first practical observations of sputtering of the Si surface during the implantation with Ag+ ions with an energy of 30 keV depending on irradiation dose D in the interval from 2.5 × 1016 to 1.5 × 1017 ion/cm2 for a fixed value of ion beam current density J = 8 μA/cm2, as well as for variation of J = 2, 5, 8, 15, and 20 μA/cm2 at constant D = 1.5 × 1017 ion/cm2. In the former case, the thickness of the porous Si (PSi) layer being sputtered increases monotonically to 50 nm at the maximum value of D; in this case, the effective sputtering ratio of the implanted Ag : PSi layer is 1.6. We have also established that the thickness of the sputtered layer increases with current density J